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    NOVEL ANILIDE COMPOUNDS AND DRUGS CONTAINING THE SAME
    4.
    发明公开
    NOVEL ANILIDE COMPOUNDS AND DRUGS CONTAINING THE SAME 失效
    ANILIDVERBINDUNGEN UND MEDIKAMENTE，DIEE ENTHALTEN

    公开(公告)号：EP1020451A1

    公开(公告)日：2000-07-19

    申请号：EP98911008.5

    申请日：1998-03-25

    申请人： Kowa Co., Ltd.

    发明人： SHIBUYA, Kimiyuki ,  KAWAMINE, Katsumi ,  SATO, Yukihiro ,  EDANO, Toshiyuki ,  HIRATA, Mitsuteru ,  OZAKI, Chiyoka

    IPC分类号： C07D233/84 ,  C07D235/28 ,  C07D263/58 ,  C07D277/70 ,  C07D413/04 ,  C07D471/04 ,  C07D498/04 ,  C07D513/04 ,  A61K31/415 ,  A61K31/42 ,  A61K31/425 ,  A61K31/435

    CPC分类号： C07D263/58 ,  C07D233/84 ,  C07D235/28 ,  C07D263/60 ,  C07D277/74 ,  C07D413/04 ,  C07D413/12 ,  C07D471/04

    摘要： The invention relates to a novel anilide compound and a pharmaceutical composition comprising the same. The invention relates to a compound represented by the following general formula:
       represents a divalent residue of benzene with a substituent(s), heterocycle-condensed benzene which may or may not have a substituent, pyridine which may or may not have a substituent, cyclohexane or naphthalene
    or


    Ar represents an aryl group which may or may not have a substituent;
    X represents -NH-, oxygen atom or sulfur atom;
    Y represents -NR 4 -, oxygen atom, sulfur atom, sulfoxide or sulfone;
    Z represents single bond or -NR 5 -;
    R 4 represents hydrogen atom, a lower alkyl group, an aryl group or a silylated lower alkyl group which may or may not have a substituent;
    R 5 represents hydrogen atom, a lower alkyl group, an aryl group or a silylated lower alkyl group which may or may not have a substituent; and
    n represents an integer of 0 to 15.

    The inventive compounds are useful in the form of pharmaceutical composition, specifically as acyl coenzyme A cholesterol acyltransferase (ACAT) inhibitor.

    摘要翻译： 本发明涉及一种新的酰苯胺化合物和包含其的药物组合物。 本发明涉及由以下通式表示的化合物：表示具有取代基的苯的二价残基，可以具有也可以不具有取代基的杂环稠合苯，可以不具有取代基的吡啶，也可以不具有 取代基，环己烷或萘或 Ar表示可以具有或不具有取代基的芳基; X表示-NH-，氧原子或硫原子; Y代表-NR4-，氧原子，硫原子，亚砜或砜; Z表示单键或-NR5-; R4代表氢原子，低级烷基，芳基或甲硅烷基化的低级烷基，可以或不具有取代基; R5表示氢原子，低级烷基，芳基或甲硅烷基化的低级烷基，其可以具有或不具有取代基; 并且n表示0至15的整数。本发明化合物可用作药物组合物的形式，特别是酰基辅酶A胆固醇酰基转移酶（ACAT）抑制剂。

    AGENT FOR TREATMENT OF MULTIPLE SCLEROSIS
    6.
    发明公开
    AGENT FOR TREATMENT OF MULTIPLE SCLEROSIS 审中-公开
    MITTEL ZUR BEHANDLUNG VON MULTIPLER SKLEROSE

    公开(公告)号：EP2127653A1

    公开(公告)日：2009-12-02

    申请号：EP08710303.2

    申请日：2008-01-28

    申请人： Kowa Co., Ltd.

    发明人： YAMABI, Masaki ,  TABUNOKI, Yuichiro ,  EDANO, Toshiyuki

    IPC分类号： A61K31/50 ,  A61P25/00 ,  C07D237/14

    CPC分类号： A61K31/50 ,  C07D237/14

    摘要： To provide a preventive and/or therapeutic drug for multiple sclerosis, which has high efficacy against multiple sclerosis, which exhibits excellent safety, and which can be orally administered.
    The invention provides a preventive and/or therapeutic drug for multiple sclerosis, the drug containing, as an active ingredient, 2-benzyl-5-(4-chlorophenyl)-6-[4-(methylthio)phenyl]-2H-pyridazin-3-one or a solvate thereof.

    摘要翻译： 提供对多发性硬化具有高效力的多发性硬化症的预防和/或治疗药物，其表现出优异的安全性，并且可以口服给药。 本发明提供了用于多发性硬化的预防和/或治疗药物，该药物含有作为活性成分的2-苄基-5-（4-氯苯基）-6- [4-（甲硫基）苯基] -2H-哒嗪-3-酮 3-或其溶剂合物。

    NOVEL CYCLIC DIAMINE COMPOUNDS AND MEDICINE CONTAINING THE SAME
    8.
    发明公开
    NOVEL CYCLIC DIAMINE COMPOUNDS AND MEDICINE CONTAINING THE SAME 失效
    新型环状二胺化合物及含有该化合物的药物

    公开(公告)号：EP0987254A1

    公开(公告)日：2000-03-22

    申请号：EP98921809.4

    申请日：1998-05-26

    申请人： Kowa Co., Ltd.

    发明人： SHIBUYA, K., 403, Lions-Hills-Nishitokorozawa ,  KAWAMINE, Katsumi, Kowa-Higashimurayama-ryo ,  SATO, Yukihiro, Kowa-Higashimurayama-ryo ,  MIURA, Toru ,  OZAKI, Chiyoka ,  EDANO, Toshiyuki ,  HIRATA, Mitsuteru

    IPC分类号： C07D233/70 ,  C07D235/28 ,  C07D263/58 ,  C07D277/74 ,  C07D277/80 ,  C07D401/12 ,  C07D413/04 ,  C07D413/12 ,  C07D417/12 ,  C07D498/04 ,  C07F9/653 ,  A61K31/495 ,  A61K31/55 ,  A61K31/505

    CPC分类号： C07D263/58 ,  C07D235/28 ,  C07D277/74 ,  C07D401/12 ,  C07D413/12 ,  C07D417/12 ,  C07F9/650958 ,  C07F9/65583

    摘要： The present invention offers novel cyclic diamine compounds and a pharmaceutical composition containing the same.
    The present invention relates to a compound represented by the formula (I) or salt(s) or solvate(s) thereof.
    (In the formula,
    is an optionally substituted divalent residue of benzene, pyridine, cyclohexane or naphthalene or is a vinylene group where

    Ar is an optionally substituted aryl group;
    X is -NH-, oxygen atom or sulfur atom;
    Y is -NR 1 -, oxygen atom, sulfur atom, sulfoxide or sulfone;
    Z is a single bond or -NR 2 -;
    R 1 is hydrogen atom, optionally substituted lower alkyl group, optionally substituted aryl group or optionally substituted silyl lower alkyl group;
    R 2 is hydrogen atom, optionally substituted lower alkyl group, optionally substituted aryl group or optionally substituted silyl lower alkyl group;
    l is an integer of from 0 to 15;
    m is an integer of 2 or 3; and
    n is an integer of from 0 to 3).

    The compound of the present invention is useful as a pharmaceutical composition, particuarly as an inhibitor of acyl coenzyme A cholesterol acyltransferase (ACAT).

    摘要翻译： 本发明提供了新型环状二胺化合物和含有其的药物组合物。 本发明涉及由式（I）表示的化合物或其盐或溶剂化物。 （式中，是苯，吡啶，环己烷或萘的任选取代的二价残基或是亚乙烯基，其中Ar是任选取代的芳基; X是-NH-，氧原子或硫原子; Y是-NR1- ，氧原子，硫原子，亚砜或砜; Z为单键或-NR2-; R1为氢原子，任选取代的低级烷基，任选取代的芳基或任选取代的甲硅烷基低级烷基; R2为氢原子，任选 取代的低级烷基，任选取代的芳基或任选取代的甲硅烷基低级烷基; l是0-15的整数; m是2或3的整数;并且n是0-3的整数。 本发明的化合物可用作药物组合物，特别是作为酰基辅酶A胆固醇酰基转移酶（ACAT）的抑制剂。