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1.发明公开ANTIBODY MOLECULES HAVING SPECIFICITY FOR HUMAN TUMOR NECROSIS FACTOR ALPHA, AND USE THEREOF 审中-公开ANTIKÖRPERMOLEKÜLEMITSPEZIFITÄTFÜRMENSCHLICHEN TUMOR-NEKTROSE-FAKTOR-ALPHA SOWIE VERWENDUNG DAVON
公开(公告)号：EP3059314A1
公开(公告)日：2016-08-24
申请号：EP16154916.7
申请日：2001-06-05
申请人： UCB Pharma, S.A.
发明人： Athwal, Diljeet Singh , Brown, Derek Thomas , Weir, Andrew Neil Charles , Popplewell, Andrew George , Chapman, Andrew Paul , King, David John
IPC分类号： C12N15/13 , C07K16/24 , C07K16/46 , A61K47/48 , C07K19/00 , C12N15/62 , C12N15/70 , C12N1/21 , A61K39/395 , A61P19/02 , A61P37/06
CPC分类号： C07K16/241 , A61K47/6845 , A61K47/6875 , A61K2039/505 , C07K2317/24 , C07K2317/565
摘要： There is disclosed antibody molecules containing at least one CDR derived from a mouse monoclonal antibody having specificity for human TNFα There is also disclosed a CDR grafted antibody wherein at least one of the CDRs is a hybrid CDR Further disclosed are DNA sequences encoding the chains of the antibody molecules, vectors, transformed host cells and uses of the antibody molecules in the treatment of diseases mediated by TNFα
摘要翻译： 公开了含有至少一种衍生自对人TNF的特异性的小鼠单克隆抗体的CDR的抗体分子。还公开了CDR移植抗体，其中至少一个CDR是杂交CDR。进一步公开的是编码 抗体分子，载体，转化的宿主细胞和抗体分子在治疗由TNF±介导的疾病中的用途
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2.发明公开Antibody molecules having specificity for human IL-6 审中-公开Antikörpermolekülemit menschlicher IL-6-Spezifizität
公开(公告)号：EP2336181A1
公开(公告)日：2011-06-22
申请号：EP10188581.2
申请日：2006-12-04
申请人： UCB Pharma, S.A.
发明人： Gelinas, Richard Evan , Singhal, Mitra Choudhury , Zhang, Yi , Popplewell, Andrew George , Adams, Ralph
IPC分类号： C07K16/24
CPC分类号： A61K39/3955 , A61K2039/505 , C07K16/248 , C07K2316/96 , C07K2317/24 , C07K2317/34 , C07K2317/54 , C07K2317/55 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C12N15/11
摘要： The invention relates to antibody molecules having specificity for antigenic determinants of IL-6, therapeutic uses of the antibody molecules and methods for producing said antibody molecules.
摘要翻译： 本发明涉及对IL-6的抗原决定簇具有特异性的抗体分子，抗体分子的治疗用途以及产生所述抗体分子的方法。
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3.发明授权Antibody molecules having specificity for human tumor necrosis factor alpha, and use thereof 有权具有特异性的人肿瘤坏死因子-α抗体分子，和它们的用途
公开(公告)号：EP2308975B1
公开(公告)日：2016-08-10
申请号：EP10010795.2
申请日：2001-06-05
申请人： UCB Pharma, S.A.
发明人： Athwal, Diljeet Singh , Brown, Derek Thomas , Weir, Andrew Neil Charles , Popplewell, Andrew George , Chapman, Andrew Paul , King, David John
IPC分类号： C12N15/13 , C07K16/24 , C07K16/46 , A61K47/48 , C07K19/00 , C12N15/62 , C12N15/70 , C12N1/21 , A61K39/395 , A61P19/02 , A61P37/06
CPC分类号： C07K16/241 , A61K47/6845 , A61K47/6875 , A61K2039/505 , C07K2317/24 , C07K2317/565
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公开(公告)号：EP2514764A3
公开(公告)日：2013-02-20
申请号：EP12175103.6
申请日：2007-10-18
申请人： UCB Pharma, S.A.
IPC分类号： C07K16/24 , A61K39/395 , C12N15/13 , A61P37/06 , A61P35/00
CPC分类号： C07K16/468 , A61K39/3955 , C07K16/244 , C07K2317/24 , C07K2317/31 , C07K2317/33 , C07K2317/565 , C07K2317/76 , C07K2317/90 , C07K2317/92
摘要： The invention relates to antibody molecules having specificity for antigenic determinants of both IL-17A and IL-17F, therapeutic uses of the antibody molecules and methods for producing said antibody molecules.
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公开(公告)号：EP2314626A1
公开(公告)日：2011-04-27
申请号：EP10188597.8
申请日：2006-12-04
申请人： UCB Pharma, S.A.
发明人： Gelinas, Richard Evan , Singhal, Mitra Choudhury , Zhang, Yi , Popplewell, Andrew George , Adams, Ralph
IPC分类号： C07K16/24
CPC分类号： A61K39/3955 , A61K2039/505 , C07K16/248 , C07K2316/96 , C07K2317/24 , C07K2317/34 , C07K2317/54 , C07K2317/55 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C12N15/11
摘要： The invention relates to antibody molecules having specificity for antigenic determinants of IL-6, therapeutic uses of the antibody molecules and methods for producing said antibody molecules.
摘要翻译： 本发明涉及对IL-6的抗原决定簇具有特异性的抗体分子，抗体分子的治疗用途以及产生所述抗体分子的方法。
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6.发明授权
公开(公告)号：EP3059314B1
公开(公告)日：2018-10-24
申请号：EP16154916.7
申请日：2001-06-05
申请人： UCB Pharma, S.A.
发明人： Athwal, Diljeet Singh , Brown, Derek Thomas , Weir, Andrew Neil Charles , Popplewell, Andrew George , Chapman, Andrew Paul , King, David John
CPC分类号： C07K16/241 , A61K47/6845 , A61K47/6875 , A61K2039/505 , C07K2317/24 , C07K2317/565
摘要： There is disclosed antibody molecules containing at least one CDR derived from a mouse monoclonal antibody having specificity for human TNF±. There is also disclosed a CDR grafted antibody wherein at least one of the CDRs is a hybrid CDR. Further disclosed are DNA sequences encoding the chains of the antibody molecules, vectors, transformed host cells and uses of the antibody molecules in the treatment of diseases mediated by TNF±.
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7.发明授权Antibody molecules having specificity for human tumor necrosis factor alpha, and use thereof 有权具有特异性的人肿瘤坏死因子-α抗体分子，和它们的用途
公开(公告)号：EP2230308B1
公开(公告)日：2013-01-23
申请号：EP09176251.8
申请日：2001-06-05
申请人： UCB Pharma S.A.
发明人： Athwal, Diljeet Singh , Brown, Derek Thomas , Weir, Andrew Neil Charles , Popplewell, Andrew George , Chapman, Andrew Paul , King, David John
IPC分类号： C12N15/13 , C07K16/24 , C07K16/46 , A61K47/48 , C07K19/00 , C12N15/62 , C12N15/70 , C12N1/21 , A61K39/395 , A61P19/02 , A61P37/06
CPC分类号： C07K16/241 , A61K47/6845 , A61K47/6875 , A61K2039/505 , C07K2317/24 , C07K2317/565
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8.发明公开Antibody molecules having specificity for human IL-1 beta 审中-公开Menschlischer IL-1 beta spezifischeAntikörper
公开(公告)号：EP2287193A1
公开(公告)日：2011-02-23
申请号：EP10182246.8
申请日：2004-02-06
申请人： UCB Pharma, S.A.
IPC分类号： C07K16/24 , C12N15/13 , C12N15/85 , C12N5/10 , A61K39/395
CPC分类号： C07K16/245 , A61K47/60 , A61K2039/505 , C07K2317/24 , C07K2317/55 , C07K2317/565
摘要： The invention relates to an antibody molecule having specificity for antigenic determinants of IL-1β, therapeutic uses of the antibody molecule and methods for producing said antibody molecule.
摘要翻译： 本发明涉及对IL-12的抗原决定簇具有特异性的抗体分子，抗体分子的治疗用途以及产生所述抗体分子的方法。
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9.发明公开Antibody molecules having specificity for human tumor necrosis factor alpha, and use thereof 有权AntikörpermolekülemitSpezifizitätfürmenschlichen Tumornekrosefaktor-alpha，und deren Verwendung
公开(公告)号：EP2230308A1
公开(公告)日：2010-09-22
申请号：EP09176251.8
申请日：2001-06-05
申请人： UCB Pharma S.A.
发明人： Athwal, Diljeet Singh , Brown, Derek Thomas , Weir, Andrew Neil Charles , Popplewell, Andrew George , Chapman, Andrew Paul , King, David John
IPC分类号： C12N15/13 , C07K16/24 , C07K16/46 , A61K47/48 , C07K19/00 , C12N15/62 , C12N15/70 , C12N1/21 , A61K39/395 , A61P19/02 , A61P37/06
CPC分类号： C07K16/241 , A61K47/6845 , A61K47/6875 , A61K2039/505 , C07K2317/24 , C07K2317/565
摘要： There is disclosed antibody molecules containing at least one CDR derived from a mouse monoclonal antibody having specificity for human TNFα. There is also disclosed a CDR grafted antibody wherein at least one of the CDRs is a hybrid CDR. Further disclosed are DNA sequences encoding the chains of the antibody molecules, vectors, transformed host cells and uses of the antibody molecules in the treatment of diseases mediated by TNFα.
摘要翻译： 公开了含有至少一种衍生自具有人TNF±特异性的小鼠单克隆抗体的CDR的抗体分子。 还公开了CDR移植抗体，其中至少一个CDR是杂交CDR。 进一步公开的是编码抗体分子链，载体，转化的宿主细胞以及抗体分子在治疗由TNF±介导的疾病中的用途的DNA序列。
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