公开(公告)号：EP1439822A1

公开(公告)日：2004-07-28

申请号：EP02777670.7

申请日：2002-10-24

申请人： UNIVERSITAT AUTONOMA DE BARCELONA ,  University of Copenhagen ,  TRANSTECHNICS, S.L.

发明人： HIDALGO PAREJA, Juan ,  GONZALEZ DUARTE, Pilar ,  GONZALEZ ENSENAT, PedroTranstechnics, S.L. ,  PENKOWA, MilenaUniversity of Copenhagen

IPC分类号： A61K9/127 ,  A61K38/17 ,  A61P25/28

CPC分类号： A61K38/17 ,  A61K9/127

摘要： The composition comprises a dispersion of nanocorpuscles in an aqueous solution as a dispersant and a pharmaceutically acceptable alcohol as co-dispersant or cosolvent, said nanocorpuscles having at least one lipid bilayer comprising at least one biliar salt, e.g. sodium cholate, and at least one phospholipid, e.g. soy lecitine; these nanocorpuscles having an average diameter lower than 500 nm; and including metallothioneine in their interior. The process for obtaining the particles comprises: a) prepare an aqueous solution of at least one biliar salt and metallothioneine; b) prepare an alcoholic solution of the phospholipid; c) jointly homogenise both solutions. This pharmaceutical composition can be used as a medicament, particularly in the treatment of neurodegenerative and neurological disorders, such as Alzheimer's disease, Parkinson's disease, multiple sclerosis, etc.