公开(公告)号：EP1769677A2

公开(公告)日：2007-04-04

申请号：EP05740634.0

申请日：2005-04-21

申请人： Universidad Aut Noma de Madrid ,  Consejo Superior de Investigaciones Cientificas

发明人： VALDIVIESO ÁMATE,Fernando, Ciudad Univ.Cantoblanco ,  BURGOS MUÑOZ, Javier S., Ciudad Univ. Cantoblanco ,  RAMÍREZ MORENO, Carlos, Ciudad Univ. Cantoblanco ,  SASTRE MERLÍN, Isabel

IPC分类号： A01K67/027

CPC分类号： G01N33/5088 ,  A01K2227/105 ,  A01K2267/0337 ,  C12N2710/16611 ,  G01N2333/035

摘要： A vertical mother-progeny transmission route of human herpesviruses has been discovered that allows developing an animal model that is useful for identifying compounds that are potentially useful in treating and/or preventing infections and diseases caused by human herpesviruses. The method for identifying such compounds comprises experimentally infecting a a non-human female animal with human herpesviruses, before or after administering the compound to be tested, crossbreeding her with a male of the same species and analyzing the presence of human herpesviruses in the progeny and/or determining the effect of said compound on the progeny or the mother. Alternatively, the compounds to be tested can be administered to the descendants carrying human herpesviruses instead of the mother and the effect on such animals is analyzed.

摘要翻译： 人类疱疹病毒的垂直母子代传输路由已经发现并允许开发的动物模型做是用于识别有用的化合物是潜在有用的治疗和/或预防由人疱疹病毒引起的感染和疾病一样。 用于鉴定检查化合物包括实验感染AA非人类雌性动物与人疱疹病毒，之前或施用所述化合物待测试后，与相同物种的雄性杂交她的和在后代分析人类疱疹病毒的存在的方法和/ 或确定性采矿所述的化合物对所述子代或母亲的效果。 备选地，待测试的化合物可以施用给携带人疱疹病毒，而不是母亲和检查分析对动物的影响的后代。