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    SYNTHETIC PEPTIDE COMPOUNDS AND METHODS OF USE
    1.
    发明公开
    SYNTHETIC PEPTIDE COMPOUNDS AND METHODS OF USE 审中-公开
    合成肽化合物和使用方法

    公开(公告)号：EP3313865A2

    公开(公告)日：2018-05-02

    申请号：EP16815455.7

    申请日：2016-06-24

    申请人： Eastern Virginia Medical School ,  Children's Health Foundation, Inc. ,  Eriko Life Sciences Ventures, LLC

    发明人： KRISHNA, Neel, K. ,  CUNNION, Kenji

    IPC分类号： C07K14/08 ,  A61K45/06 ,  A61K38/16

    CPC分类号： C07K14/005 ,  A61K38/00 ,  C12N2710/16611 ,  C12N2770/12022

    摘要： The present invention provides synthetic peptide compounds and uses thereof for therapy and diagnostics of complement-mediated diseases, such as inflammatory diseases, autoimmune diseases, and microbial and bacterial infections; and non-complement-mediated diseases, such cystic fibrosis and various acute diseases. The invention is directed to modifications of a synthetic peptide of 15 amino acids from the Polar Assortant (PA) peptide, which is a scrambled peptide derived from human Astrovirus protein. In some embodiments, the invention is directed to peptide compounds that are peptide mimetics, peptide analogs and/or synthetic derivatives of PA (e.g., sarcosine derivatives) having, for example, internal peptide substitutions, and modifications, including PEGylation at the N-terminus and C-terminus. The invention further provides methods of selecting at least one synthetic peptide for treating various conditions.

    MUTANT HSV, MATERIALS AND METHODS FOR GENERATION OF MUTANT HSV
    3.
    发明公开
    MUTANT HSV, MATERIALS AND METHODS FOR GENERATION OF MUTANT HSV 有权
    MUTANTES HSV，生产HSV突变体材料与方法

    公开(公告)号：EP2016182A1

    公开(公告)日：2009-01-21

    申请号：EP07732664.3

    申请日：2007-05-04

    申请人： Crusade Laboratories Limited

    发明人： CONNER, Joe

    IPC分类号： C12N15/869

    CPC分类号： C12N15/86 ,  C12N15/869 ,  C12N15/8695 ,  C12N2710/16034 ,  C12N2710/16041 ,  C12N2710/16061 ,  C12N2710/16611 ,  C12N2710/16634 ,  C12N2710/16643 ,  C12N2710/16651

    摘要： A method of generating a mutant Herpes Simplex Virus (HSV) is disclosed, wherein the generated HSV genome comprises nucleic acid encoding a nucleic acid sequence of interest, the method comprising the steps of: i. providing a nucleic acid vector comprising nucleic acid encoding first and second site specific recombination sequences and a nucleic acid encoding a nucleic acid sequence of interest between said site specific recombination sequences; ii. providing an HSV, the genome of which comprises third and fourth site specific recombination sequences; iii. contacting said nucleic acid vector of (i) with said HSV of (ii) together with one or more recombinase enzymes capable of catalysing site specific recombination between the site specific recombination sequences of said nucleic acid vector and said HSV; iv. identifying HSV containing the nucleic acid sequence of interest, wherein steps i-iii are conducted in a cell-free system.

    METHOD FOR DETECTION OF CANCER CELLS USING VIRUS
    6.
    发明授权
    METHOD FOR DETECTION OF CANCER CELLS USING VIRUS 有权
    方法检测癌细胞利用病毒

    公开(公告)号：EP1979000B1

    公开(公告)日：2011-07-13

    申请号：EP06847911.2

    申请日：2006-12-21

    申请人： MEMORIAL SLOAN-KETTERING CANCER CENTER

    发明人： FONG, Yuman ,  ADUSUMILLI, Prasad S.

    IPC分类号： C12Q1/68

    CPC分类号： C12Q1/6897 ,  A61K35/13 ,  C12N2710/16611 ,  C12N2710/24111 ,  G01N33/574

    摘要： The invention relates to compositions and methods for cancer cell detection in bodily samples wherein a cancer cell can be detected within a mixed population of cancer cells and non-cancer cells. The invention also relates to compositions and methods that may be used in cancer cell detection, specifically viruses that are replication-competent conditional to a cancer cell, in particular an oncolytic herpes virus, such as NV 1066 and a vaccinia virus, such as GLV-lh68. Provided are methods and kits for using these viruses that preferentially replicate in cancer cells and may also preferentially infect cancer cells for specific identification of such cancer cells, even when a cancer cell is present, for example, at a ratio of one infected cancer cell in a background often thousand non-cancer cells, thus further providing a reproducible and sensitive screening method for cancer detection, monitoring and prognosis.

    METHOD FOR DETECTION OF CANCER CELLS USING VIRUS
    7.
    发明公开
    METHOD FOR DETECTION OF CANCER CELLS USING VIRUS 有权
    方法检测癌细胞利用病毒

    公开(公告)号：EP1979000A2

    公开(公告)日：2008-10-15

    申请号：EP06847911.2

    申请日：2006-12-21

    申请人： MEMORIAL SLOAN-KETTERING CANCER CENTER

    发明人： FONG, Yuman ,  ADUSUMILLI, Prasad

    IPC分类号： A61K39/395 ,  C12Q1/70 ,  G01N33/574

    CPC分类号： C12Q1/6897 ,  A61K35/13 ,  C12N2710/16611 ,  C12N2710/24111 ,  G01N33/574

    摘要： The invention relates to compositions and methods for cancer cell detection in bodily samples wherein a cancer cell can be detected within a mixed population of cancer cells and non-cancer cells. The invention also relates to compositions and methods that may be used in cancer cell detection, specifically viruses that are replication-competent conditional to a cancer cell, in particular an oncolytic herpes virus, such as NV 1066 and a vaccinia virus, such as GLV-lh68. Provided are methods and kits for using these viruses that preferentially replicate in cancer cells and may also preferentially infect cancer cells for specific identification of such cancer cells, even when a cancer cell is present, for example, at a ratio of one infected cancer cell in a background often thousand non-cancer cells, thus further providing a reproducible and sensitive screening method for cancer detection, monitoring and prognosis.