公开(公告)号：EP3084436A4

公开(公告)日：2017-05-24

申请号：EP14872357

申请日：2014-12-17

申请人： BOARD OF TRUSTEES SOUTHERN ILLINOIS UNIV

发明人： HALFORD WILLIAM P

IPC分类号： G01N33/53

CPC分类号： G01N33/56994 ,  G01N2333/035 ,  G01N2469/20

摘要： An assay for infection with one or more herpes simplex viruses that comprises a) dividing an antibody-containing serum sample into at least three serum subsamples, and b) separately incubating each with a physical matrix of cell antigens from i) uninfected cells, (ii) HSV-1-infected cells, or (iii) HSV-2-infected cells to form at least three serum subsample admixtures so that antibodies present in each admixture can immunoreact to form matrix-bound antibodies and at least three preadsorbed serum subsample portions. Each preadsorbed serum subsample portion is incubated with a mixture of matrix-bound antigens from cells uninfected by HSV-1 or HSV-2, infected by each of HSV-1 and by HSV-2 to permit antibodies to immunoreact with antigens present to form three matrix-bound immunoreactants. The amount of each immunoreaction is determined, and reaction amounts are prognostic for whether the subject whose serum was tested is infected by one, both, or neither of HSV-1 and HSV-2.

摘要翻译： 一种用一种或多种单纯疱疹病毒感染的测定，其包括a）将含有抗体的血清样品分成至少三个血清子样品，和b）分别与来自i）未感染细胞的细胞抗原的物理基质孵育，（ii） ）HSV-1感染的细胞或（iii）HSV-2感染的细胞以形成至少三种血清亚样品混合物，使得存在于每种混合物中的抗体可以免疫反应以形成基质结合的抗体和至少三种预先吸附的血清亚样品部分。 将每个预先吸附的血清子样品部分与来自HSV-1或HSV-2感染的细胞的基质结合抗原的混合物一起孵育，所述HSV-1或HSV-2感染HSV-1和HSV-2中的每一种，以允许抗体与存在的抗原免疫反应以形成三 基质结合的免疫反应物。 确定每种免疫反应的量，并且反应量对于其血清被测试的受试者是否感染HSV-1和HSV-2中的一种，两者或两者都是预后的。

公开(公告)号：EP2987859A1

公开(公告)日：2016-02-24

申请号：EP15187953.3

申请日：2008-09-25

申请人： Japan Tobacco Inc. ,  Virus Ikagaku Kenkyusho Inc.

发明人： KONDO, Kazuhiro ,  KOBAYASHI, Nobuyuki

IPC分类号： C12N15/09 ,  A01K67/027 ,  C07K14/03 ,  C07K16/08 ,  C12M1/00 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  G01N33/15 ,  G01N33/50 ,  G01N33/53 ,  G01N33/569 ,  C12Q1/68 ,  C07K14/005 ,  C12N7/00 ,  G01N33/68

CPC分类号： C07K14/005 ,  A01K2267/0356 ,  C12N7/00 ,  C12N2710/10343 ,  C12N2710/16522 ,  C12N2710/16571 ,  C12N2740/10043 ,  G01N33/6854 ,  G01N33/6893 ,  G01N33/6896 ,  G01N2333/035 ,  G01N2800/304

摘要： Disclosed are a protein and a gene each of which is a factor involved in latent infection with a herpesvirus. An antibody against the factor was detected in approximately 50% of patients suffering from mental disorders, whereas the antibody was hardly detected in healthy persons. Further, a mouse having SITH-1 introduced therein developed a mental disorder such as a manic-depressive illness or depression-like disorder. Based on these findings, it is possible to provide a method for objectively determining a mental disorder and an animal model of a mental disorder.

摘要翻译： 公开了蛋白质和基因，每种蛋白质和基因都是涉及疱疹病毒潜伏感染的因素。 在大约50％的精神障碍患者中检测到抗因子抗体，而在健康人中几乎检测不出抗体。 此外，其中引入了SITH-1的小鼠产生精神障碍，例如躁狂抑郁症或抑郁症状障碍。 基于这些发现，可以提供客观地确定精神障碍和精神障碍的动物模型的方法。

公开(公告)号：EP2199391B1

公开(公告)日：2015-11-11

申请号：EP08833887.6

申请日：2008-09-25

申请人： Japan Tobacco, Inc. ,  Virus Ikagaku Kenkyusho Inc.

发明人： KONDO, Kazuhiro ,  Kobayashi, Nobuyuki

IPC分类号： C07K14/005 ,  C12N7/00 ,  G01N33/68

CPC分类号： C07K14/005 ,  A01K2267/0356 ,  C12N7/00 ,  C12N2710/10343 ,  C12N2710/16522 ,  C12N2710/16571 ,  C12N2740/10043 ,  G01N33/6854 ,  G01N33/6893 ,  G01N33/6896 ,  G01N2333/035 ,  G01N2800/304

摘要： Disclosed are a protein and a gene each of which is a factor involved in latent infection with a herpesvirus. An antibody against the factor was detected in approximately 50% of patients suffering from mental disorders, whereas the antibody was hardly detected in healthy persons. Further, a mouse having SITH-1 introduced therein developed a mental disorder such as a manic-depressive illness or depression-like disorder. Based on these findings, it is possible to provide a method for objectively determining a mental disorder and an animal model of a mental disorder.

公开(公告)号：EP2392644A2

公开(公告)日：2011-12-07

申请号：EP11004178

申请日：2011-05-20

申请人： FRAUNHOFER GES FORSCHUNG

发明人： BURGER-KENTISCHER ANKE DR ,  HOGK INA ,  FINKELMEIER DORIS ,  WALLES HEIKE PROF DR ,  RUPP STEFFEN DR RER NAT ,  KAUFMANN MICHAELA DR

IPC分类号： G01N33/50 ,  C12N5/00

CPC分类号： G01N33/5058 ,  A61F2/105 ,  G01N2333/035

摘要： Die Erfindung betrifft ein mehrschichtiges biologisches in vitro-Gewebe, enthaltend: Dermisschicht, enthaltend eine Kollagenbiomatrix mit darin eingebetteten Fibroblasten und Epidermisschicht, enthaltend Epithelzellen. Es ist vorgesehen, dass zumindest in die Dermisschicht latent viral infizierte neuronale Zellen integriert sind.

摘要翻译： 要求包含含有嵌入其中的成纤维细胞的胶原生物基质和含有上皮细胞的表皮层的真皮层的多层生物体外组织，其中潜伏的病毒感染的神经元细胞整合到真皮层中。 独立权利要求包括：（1）作为体外试验系统制备多层生物组织的方法，包括提供含有真皮层的多层组织，含有成纤维细胞的胶原生物基质和含有上皮细胞的表皮层 并且在多层生物组织上接种病毒感染的神经元细胞，使得它们被整合到生物组织中; （2）从一组待检查物质中发现具有抗病毒作用的活性成分的方法，包括提供多层生物体外组织，使病毒感染在组织的潜伏病毒感染的神经细胞中反应，使 病毒激活之前或之后的组织与待检查物质接触，以及验证与未与物质接触的组织相比病毒活化程度降低的病毒活化程度表明抗病毒作用 物质。

公开(公告)号：EP2112158B1

公开(公告)日：2011-10-19

申请号：EP09009877.3

申请日：2008-03-31

申请人： F. Hoffmann-La Roche AG ,  Roche Diagnostics GmbH

发明人： Faatz, Elke, Dr. ,  Schaarschmidt, Peter, Dr. ,  Scholz, Christian, Dr. ,  Schmitt, Urban

IPC分类号： C07K14/195 ,  G01N33/68

CPC分类号： G01N33/6854 ,  C07K14/20 ,  C07K14/245 ,  C07K14/45 ,  C07K14/47 ,  C07K2319/70 ,  C12N15/62 ,  C12N2710/16122 ,  C12N2710/16134 ,  G01N2333/02 ,  G01N2333/035 ,  G01N2333/04 ,  G01N2333/045 ,  G01N2333/05 ,  G01N2333/19 ,  G01N2333/45

公开(公告)号：EP2199391A4

公开(公告)日：2011-01-19

申请号：EP08833887

申请日：2008-09-25

申请人： JAPAN TOBACCO INC ,  VIRUS IKAGAKU KENKYUSHO INC

发明人： KONDO KAZUHIRO ,  KOBAYASHI NOBUYUKI

IPC分类号： C12N15/09 ,  A01K67/027 ,  C07K14/03 ,  C07K16/08 ,  C12M1/00 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12Q1/68 ,  G01N33/15 ,  G01N33/50 ,  G01N33/53 ,  G01N33/569

CPC分类号： C07K14/005 ,  A01K2267/0356 ,  C12N7/00 ,  C12N2710/10343 ,  C12N2710/16522 ,  C12N2710/16571 ,  C12N2740/10043 ,  G01N33/6854 ,  G01N33/6893 ,  G01N33/6896 ,  G01N2333/035 ,  G01N2800/304

摘要： Disclosed are a protein and a gene each of which is a factor involved in latent infection with a herpesvirus. An antibody against the factor was detected in approximately 50% of patients suffering from mental disorders, whereas the antibody was hardly detected in healthy persons. Further, a mouse having SITH-1 introduced therein developed a mental disorder such as a manic-depressive illness or depression-like disorder. Based on these findings, it is possible to provide a method for objectively determining a mental disorder and an animal model of a mental disorder.

公开(公告)号：EP1786934A1

公开(公告)日：2007-05-23

申请号：EP05771876.9

申请日：2005-08-15

申请人： Athlomics Pty Ltd

发明人： BRANDON, Richard, Bruce ,  THOMAS, Mervyn, Rees

IPC分类号： C12Q1/70 ,  C12Q1/68 ,  G01N33/48 ,  G01N33/50

CPC分类号： C12Q1/705 ,  G01N33/56994 ,  G01N2333/035 ,  G01N2469/10

摘要： The present invention discloses microarray-based methods for the diagnosis of Herpes Virus infection from peripheral blood samples. It discloses the expression of host’s disease-associated genes and their use in assays for diagnosis and assessment of animal with herpes virus infection. This invention allows monitoring of an infected animal’s immune response and thus enables better treatment and management decisions to be made in clinical and sub-clinically affected animals.

公开(公告)号：EP1492563A4

公开(公告)日：2006-03-15

申请号：EP03718356

申请日：2003-04-09

申请人： CORIXA CORP

发明人： DAY CRAIG H ,  HOSKEN NANCY A ,  PARSONS JOSEPH M

IPC分类号： G01N33/53 ,  A61K31/704 ,  A61K31/7088 ,  A61K38/00 ,  A61K39/00 ,  A61K45/00 ,  A61K48/00 ,  A61P31/22 ,  C07K14/035 ,  C07K16/08 ,  C07K19/00 ,  C12N5/02 ,  C12N5/08 ,  C12N15/09 ,  C12P21/08 ,  G01N33/569 ,  A61K39/12 ,  A61K39/245 ,  C12P19/34

CPC分类号： C07K14/005 ,  A61K38/00 ,  A61K39/00 ,  A61K2039/53 ,  C07K2319/00 ,  C12N2710/16622 ,  G01N33/56994 ,  G01N2333/035

公开(公告)号：EP1034430B1

公开(公告)日：2006-02-08

申请号：EP98957299.5

申请日：1998-11-24

申请人： Q-SENSE

发明人： HÖÖK, Fredrik

IPC分类号： G01N33/543 ,  G01G3/16 ,  G01R29/22 ,  G01N27/00

CPC分类号： G01N29/036 ,  G01N33/54373 ,  G01N2291/0257 ,  G01N2333/035

摘要： The present invention relates to a method for measuring of the interaction between at least one target molecule and at least one receptor molecule using a piezo-electric crystal micro balance, where at least one type of the molecules is immobilised, whereby at least one crystal is brought into oscillation by means of a driving circuit, and measuring the dissipation (D) and/or change in dissipation (ΔD) during driving and/or after switching off the driving circuit.

公开(公告)号：EP2987859B1

公开(公告)日：2018-08-08

申请号：EP15187953.3

申请日：2008-09-25

申请人： Japan Tobacco Inc. ,  Virus Ikagaku Kenkyusho Inc.

发明人： KONDO, Kazuhiro ,  KOBAYASHI, Nobuyuki

IPC分类号： C12N15/09 ,  A01K67/027 ,  C07K14/03 ,  C07K16/08 ,  C12M1/00 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  G01N33/15 ,  G01N33/50 ,  G01N33/53 ,  G01N33/569 ,  C12Q1/68 ,  C07K14/005 ,  C12N7/00 ,  G01N33/68

CPC分类号： C07K14/005 ,  A01K2267/0356 ,  C12N7/00 ,  C12N2710/10343 ,  C12N2710/16522 ,  C12N2710/16571 ,  C12N2740/10043 ,  G01N33/6854 ,  G01N33/6893 ,  G01N33/6896 ,  G01N2333/035 ,  G01N2800/304

摘要： Disclosed are a protein and a gene each of which is a factor involved in latent infection with a herpesvirus. An antibody against the factor was detected in approximately 50% of patients suffering from mental disorders, whereas the antibody was hardly detected in healthy persons. Further, a mouse having SITH-1 introduced therein developed a mental disorder such as a manic-depressive illness or depression-like disorder. Based on these findings, it is possible to provide a method for objectively determining a mental disorder and an animal model of a mental disorder.