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公开(公告)号：EP3621596A1
公开(公告)日：2020-03-18
申请号：EP18738197.5
申请日：2018-05-09
申请人： Université de Bordeaux , Centre National de la Recherche Scientifique , Institut Polytechnique de Bordeaux , Ecole Nationale Superieure d'Arts et Metiers , Université Paris Descartes , École Nationale Superieure de Chimie de Paris - Chimie Paristech , Paris Sciences Et Lettres (PSL) Research Universit , Institut National de la Santé et de la Recherche Médicale
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2.发明授权VECTEURS COMPRENANT UNE MACROMOLÉCULE ANIONIQUE ET UN LIPIDE CATIONIQUE POUR L'ADMINISTRATION DE PETITS ACIDES NUCLÉIQUES 有权载体，包括配电小核酸的阴离子MACRO分子和阳离子脂质
公开(公告)号：EP2389158B1
公开(公告)日：2014-03-12
申请号：EP10701502.6
申请日：2010-01-20
申请人： Centre National de la Recherche Scientifique CNRS , Université Paris Descartes , INSERM - Institut National de la Santé et de la Recherche Médicale
CPC分类号： A61K9/1272 , A61K47/34 , A61K47/36 , A61K47/6911 , C12N15/87 , C12N15/88
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3.发明公开VECTEURS COMPRENANT UNE MACROMOLÉCULE ANIONIQUE ET UN LIPIDE CATIONIQUE POUR L'ADMINISTRATION DE PETITS ACIDES NUCLÉIQUES 有权载体，包括配电小核酸的阴离子MACRO分子和阳离子脂质
公开(公告)号：EP2389158A1
公开(公告)日：2011-11-30
申请号：EP10701502.6
申请日：2010-01-20
申请人： Centre National de la Recherche Scientifique CNRS , Université Paris Descartes , INSERM - Institut National de la Santé et de la Recherche Médicale
CPC分类号： A61K9/1272 , A61K47/34 , A61K47/36 , A61K47/6911 , C12N15/87 , C12N15/88
摘要： The invention relates to a composition including (1) an anionic macromolecule except nucleic acids, (2) a cationic lip, and (3) a nucleic acid having a size lower than or equal to 200 nucleotides, such as an interference RNA, and to the use thereof in gene therapy.
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4.发明公开
公开(公告)号：EP1871890A2
公开(公告)日：2008-01-02
申请号：EP06779741.5
申请日：2006-04-18
CPC分类号： C12N15/87 , A61K9/0048 , A61K38/00 , A61K48/00 , A61N1/0543 , A61N1/306 , A61N1/327 , A61N1/36046
摘要： The present invention relates, generally, to improved methods of delivering a biologically active agent, in particular a therapeutic or prophylactic nucleic acid, to the ocular sphere of a subject comprising administering said agent to the ciliary body tissue(s) or cells and/or to the extra-ocular muscle tissue or cells. More particularly, the invention relates to devices, their uses, notably in gene therapy, and to methods for treating pathologies of the ocular sphere by specific ciliary body tissue(s) or cells and/or extra-ocular muscle or cells administration of a therapeutic product and transfer thereof into the ocular tissue to be treated. This invention also relates to pharmaceutical compositions comprising the product in a form suitable for ciliary body tissue(s) or cells and/or extra-ocular muscle or cells administration, their preparation and uses.
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5.发明授权METHODS AND DEVICES FOR DELIVERING A THERAPEUTIC PRODUCT TO THE OCULAR SPHERE OF A SUBJECT 有权用于递送治疗产品的方法和器械在患者的眼球
公开(公告)号：EP1871890B1
公开(公告)日：2011-06-15
申请号：EP06779741.5
申请日：2006-04-18
CPC分类号： C12N15/87 , A61K9/0048 , A61K38/00 , A61K48/00 , A61N1/0543 , A61N1/306 , A61N1/327 , A61N1/36046
摘要： The present invention relates, generally, to improved methods of delivering a biologically active agent, in particular a therapeutic or prophylactic nucleic acid, to the ocular sphere of a subject comprising administering said agent to the ciliary body tissue(s) or cells and/or to the extra-ocular muscle tissue or cells. More particularly, the invention relates to devices, their uses, notably in gene therapy, and to methods for treating pathologies of the ocular sphere by specific ciliary body tissue(s) or cells and/or extra-ocular muscle or cells administration of a therapeutic product and transfer thereof into the ocular tissue to be treated. This invention also relates to pharmaceutical compositions comprising the product in a form suitable for ciliary body tissue(s) or cells and/or extra-ocular muscle or cells administration, their preparation and uses.
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6.发明公开PROCÉDÉ D'IMMUNISATION GÉNÉTIQUE PAR ÉLECTROTRANSFERT CONTRE UNE TOXINE ET ANTISÉRUM SUSCEPTIBLE D'ÊTRE OBTENU PAR LEDIT PROCÉDÉ 审中-公开PROCEDURE基因免疫电动TRANSFER针对毒素在这个过程中获得的抗血清
公开(公告)号：EP1906996A2
公开(公告)日：2008-04-09
申请号：EP06778059.3
申请日：2006-07-28
申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) , INSTITUT PASTEUR , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) , Université René Descartes
IPC分类号： A61K39/08 , A61K31/7088
CPC分类号： A61K39/08 , A61K2039/53 , A61K2039/54
摘要： The invention concerns a method for obtaining an antiserum directed against a proteinic toxin by administering to an animal a solution comprising a genetic construct encoding a toxin immunogenic fragment, then applying an electric field in the administering zone, and isolating the serum. The invention also concerns the antiserum obtainable by the method as well as the use of the solution for making a medicine for preventing or treating a toxic effect related to absorption by a mammal of a toxin. The invention is characterized in that said medicine is formulated to be administered by electrotransfer.
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