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1.发明公开
公开(公告)号：EP4168406A1
公开(公告)日：2023-04-26
申请号：EP21740400.3
申请日：2021-06-18
发明人： FELTS, Andrew, S. , HAN, Changho , CAPSTICK, Rory, A. , ORSI, Douglas, L. , WHOMBLE, David, L. , LINDSLEY, Craig, W. , CONN, P., Jeffrey
IPC分类号： C07D417/14 , C07D417/12 , C07D405/14 , C07D471/04 , C07D513/04 , A61K31/454 , A61K31/4523 , A61P25/18
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2.发明公开INDOLEACETIC ACID AND INDENACETIC ACID DERIVATIVES AS THERAPEUTIC AGENTS WITH REDUCED GASTROINTESTINAL TOXICITY 审中-公开不饱和脂肪酸不饱和脂肪酸治疗WIRKSTOFFE麻醉剂VERMINDERTER GASTROINTESTITERERTOXIZITÄT
公开(公告)号：EP1744747A2
公开(公告)日：2007-01-24
申请号：EP05778497.7
申请日：2005-04-26
IPC分类号： A61K31/405
CPC分类号： C07C233/11 , A61K31/405 , C07C235/34 , C07C247/12 , C07C317/44 , C07C323/62 , C07C2601/14 , C07D209/26
摘要： The presently disclosed subject matter provides derivatives of nonsteroidal anti-inflammatory drugs (NSAIDs) that are characterized by substantially reduced cyclooxygenase inhibiting activity, yet retain the ability to interact with and modulate the activities of other polypeptides such as the class of peroxisome proliferators-activated receptors (PPARs) and Ϝ-secretase. Also provided are methods of using the derivatives to treat pathological disorders.
摘要翻译： 目前公开的主题提供非甾体抗炎药（NSAID）的衍生物，其特征在于显着降低的环加氧酶抑制活性，但保留与其它多肽的活性相互作用和调节的能力，例如过氧化物酶体增殖物 - 活化受体（PPAR）和γ-分泌酶。 还提供了使用衍生物治疗病理性疾病的方法。
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3.发明公开SUBSTITUTED BENZAMIDE ANALOGS AS MGLUR5 NEGATIVE ALLOSTERIC MODULATORS AND METHODS OF MAKING AND USING THE SAME 审中-公开取代BENZAMIDANALOGA负变构mGluR5调节剂和方法的生产和使用
公开(公告)号：EP2477630A1
公开(公告)日：2012-07-25
申请号：EP10817950.8
申请日：2010-09-17
发明人： CONN, P., Jeffrey , LINDSLEY, Craig, W. , EMMITTE, Kyle, A. , WEAVER, Charles, David , RODRIGUEZ, Alice, L. , FELTS, Andrew, S. , JONES, Carrie, K. , BATES, Brittney, S.
IPC分类号： A61K31/535
CPC分类号： A61K31/4406 , A61K31/497 , C07D401/12 , C07D401/14
摘要： Disclosed are negative allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with glutamate dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
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4.发明公开SUBSTITUTED HETEROARYLAMIDE ANALOGS AS MGLUR5 NEGATIVE ALLOSTERIC MODULATORS AND METHODS OF MAKING AND USING THE SAME 有权取代HETEROARYLAMIDANALOGE负的mGluR5变构调节剂，和方法的生产和使用
公开(公告)号：EP2477629A1
公开(公告)日：2012-07-25
申请号：EP10817936.7
申请日：2010-09-17
发明人： CONN, P., Jeffrey , LINDSLEY, Craig, W. , EMMITTE, Kyle, A. , WEAVER, Charles, David , RODRIGUEZ, Alice, L. , FELTS, Andrew, S. , JONES, Carrie, K. , BATES, Brittney, S.
IPC分类号： A61K31/535
CPC分类号： A61K31/4406 , A61K31/497 , C07D401/12 , C07D401/14
摘要： Disclosed are negative allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with glutamate dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention
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5.发明公开
公开(公告)号：EP4402137A1
公开(公告)日：2024-07-24
申请号：EP22870624.8
申请日：2022-09-14
发明人： LINDSLEY, Craig, W. , CONN, P., Jeffrey , FELTS, Andrew, S. , CAPSTICK, Rory, A. , TEMPLE, Kayla, J. , RINGUETTE, Anna, E. , HENDERSON, Scott, H. , WHOMBLE, David, L.
IPC分类号： C07D401/12 , C07D417/12 , A61K31/444 , A61K31/4439 , A61P25/00
CPC分类号： A61P25/00 , C07D417/12 , A61P25/28 , C07D213/75 , C07D401/12 , A61K45/06
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6.发明授权SUBSTITUTED HETEROARYLAMIDE ANALOGS AS MGLUR5 NEGATIVE ALLOSTERIC MODULATORS AND METHODS OF MAKING AND USING THE SAME 有权取代HETEROARYLAMIDANALOGE负的mGluR5变构调节剂，和方法的生产和使用
公开(公告)号：EP2477629B1
公开(公告)日：2016-08-03
申请号：EP10817936.7
申请日：2010-09-17
发明人： CONN, Jeffrey, P. , LINDSLEY, Craig, W. , EMMITTE, Kyle, A. , WEAVER, Charles, David , RODRIGUEZ, Alice, L. , FELTS, Andrew, S. , JONES, Carrie, K. , BATES, Brittney, S.
IPC分类号： A61K31/535 , A61K31/4406 , A61K31/497 , C07D401/12 , C07D401/14 , A61P25/00
CPC分类号： A61K31/4406 , A61K31/497 , C07D401/12 , C07D401/14
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7.发明公开6-ALKYL-N-(PYRIDIN-2-YL)-4-ARYLOXYPICOLINAMIDE ANALOGS AS MGLUR5 NEGATIVE ALLOSTERIC MODULATORS AND METHODS OF MAKING AND USING THE SAME 审中-公开1-6 - 烷基-N-（吡啶-2-基）-4- aryloxypicolinamide类似物作为阴性的mGluR5变构调节剂及其制备方法和使用
公开(公告)号：EP2680849A2
公开(公告)日：2014-01-08
申请号：EP12752374.4
申请日：2012-03-05
发明人： CONN, P., Jeffrey , LINDSLEY, Craig, W. , EMMITTE, Kyle, A. , RODRIGUEZ, Alice, L. , FELTS, Andrew, S. , JONES, Carrie, K. , BATES, Brittney, S. , CHAUDER, Brian, A.
IPC分类号： A61K31/513 , C07D401/14
CPC分类号： C07D401/14 , A61K31/513 , C07D213/81 , C07D401/12
摘要： Disclosed are negative allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with glutamate dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
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