公开(公告)号：EP4404769A1

公开(公告)日：2024-07-31

申请号：EP22783497.5

申请日：2022-09-21

申请人： Société des Produits Nestlé S.A.

发明人： MARTIN, François-Pierre ,  DARIMONT-NICOLAU, Christian ,  MANTANTZIS, Konstantinos ,  FRANCEY, Célia ,  MOULLAN, Norman

IPC分类号： A23L33/105 ,  A23L33/19 ,  A23L33/20 ,  A61K36/605 ,  A61P25/20 ,  A61P43/00

CPC分类号： A23L33/105 ,  A23L33/19 ,  A23L33/20 ,  A61K36/605 ,  A61P25/20 ,  A61K33/30 ,  A61K33/06 ,  A61K31/405 ,  A61K35/20

公开(公告)号：EP3206987B2

公开(公告)日：2024-07-24

申请号：EP15851357.2

申请日：2015-10-14

IPC分类号： B82B1/00 ,  A61K9/14 ,  A61K31/395 ,  A61K31/409 ,  A61K31/5415 ,  A61K31/28 ,  A61K31/282 ,  A61P35/00 ,  B82Y5/00

CPC分类号： A61K31/282 ,  A61K31/409 ,  B82Y5/00 ,  A61K41/0038 ,  A61K41/0057 ,  A61K41/0071 ,  A61K31/337 ,  A61K31/405 ,  A61K31/4188 ,  A61K31/4745 ,  A61K31/519 ,  A61K31/704 ,  A61K9/0009 ,  A61P35/00 ,  A61P35/02 ,  A61P35/04 ,  A61K31/395

公开(公告)号：EP2260846B1

公开(公告)日：2018-11-28

申请号：EP10075396.1

申请日：2004-02-20

申请人： Lankenau Institute for Medical Research

发明人： Prendergast, George C ,  Muller, Alexander J ,  Duhadaway, James B ,  Malachowski, William

IPC分类号： A61K31/405 ,  A61K31/06 ,  A61K31/337 ,  A61K31/24 ,  A61P35/00

CPC分类号： C07D403/06 ,  A61K31/353 ,  A61K31/405 ,  A61K31/4745 ,  A61K38/04 ,  A61K45/06 ,  C07D209/14 ,  C07D403/12 ,  C07D403/14 ,  C07D471/04 ,  C07D513/04 ,  C07D517/04 ,  A61K2300/00

摘要： Compositions and methods for the treatment of malignancy and chronic viral infection are disclosed.

公开(公告)号：EP2629615B1

公开(公告)日：2018-10-10

申请号：EP11835206.1

申请日：2011-10-21

申请人： Duke University

发明人： JACOBSEN, Jacob, P.R. ,  CARON, Marc, G.

IPC分类号： A61K31/495 ,  A61K35/50 ,  A01N43/58 ,  A61P25/24 ,  A61P25/22

CPC分类号： A61K9/7084 ,  A61K9/0014 ,  A61K9/7023 ,  A61K9/7038 ,  A61K31/137 ,  A61K31/138 ,  A61K31/343 ,  A61K31/405 ,  A61K45/06 ,  A61K2300/00

摘要： The present invention concerns the treatment of serotonergic dysregulation disorders and/or augmentation of serotonin levels in the brain by add-on treatments to serotonin enhancers, and slow-release formulations of 5-hydroxytryptophan (5-HTP) therefor.

公开(公告)号：EP2736506B1

公开(公告)日：2018-09-05

申请号：EP12748805.4

申请日：2012-07-26

申请人： University Of Southern California

发明人： SHIH, Jean C. ,  CHUNG, Leland ,  ZHAU, Haiyen E. ,  WU, Boyang Jason ,  OLENYUK, Bogdan

IPC分类号： A61P35/00 ,  A61K47/55

CPC分类号： A61K31/137 ,  A61K31/352 ,  A61K31/357 ,  A61K31/366 ,  A61K31/381 ,  A61K31/405 ,  A61K31/5375 ,  A61K31/713 ,  A61K47/545 ,  A61K47/55 ,  A61K47/6929 ,  A61K49/0032 ,  C12N15/1137 ,  C12N2310/14 ,  C12N2310/531 ,  C12Y104/03004

摘要： A mechanism of monoamine oxidases (MAOs) driven epithelium-to-mesenchymal transition (EMT) is disclosed. Also disclosed are methods for treating cancer by inhibiting or suppressing MAOs in cancer cells. Novel MAOs inhibitors, such as small molecules, siRNA, shRNA, antisense oligonucleotides, aptamers, decoys, and pharmaceutical compositions useful for treating cancer by disrupting the workings of MAOs are provided. In particular, a class of conjugates formed by covalently conjugating near infrared dye 783, IR-780, and MHI-148 to a MAO inhibitor, such as clorgyline, with and without encapsulation it in a nanoparticle is provided. Other aspects of the invention include methods for forming the nano-conjugates, method for monitoring treatment progress in a cancer patient by monitoring the changes in MAO activity, methods for screening patients who are at risk of cancer or differentiating different forms of cancer by assaying the level and location of MAO activity.

公开(公告)号：EP2858648B1

公开(公告)日：2018-08-22

申请号：EP13800857.8

申请日：2013-06-07

申请人： Beth Israel Deaconess Medical Center, Inc. ,  The United States of America as represented by the Secretary, Department of Health and Human Services

发明人： LU, Kun, Ping ,  BOXER, Matthew, Brian ,  DAVIS, Mindy Irene, Emily ,  PRAGANI, Rajan ,  SHEN, Min ,  SIMEONOV, Anton, Momtchilov ,  WEI, Shuo ,  ZHOU, Xiao, Zhen

IPC分类号： A61K31/473 ,  C12N9/90 ,  A61P35/00 ,  A61P29/00

CPC分类号： A61K31/5377 ,  A61K31/185 ,  A61K31/341 ,  A61K31/357 ,  A61K31/365 ,  A61K31/381 ,  A61K31/382 ,  A61K31/402 ,  A61K31/4025 ,  A61K31/404 ,  A61K31/405 ,  A61K31/4245 ,  A61K31/427 ,  A61K31/428 ,  A61K31/4704 ,  A61K31/473 ,  A61K31/496 ,  A61K45/06 ,  A61K2300/00

摘要： The invention features compositions and methods for inhibiting the Pin1 protein, and the treatment of disorders characterized by elevated Pin1 levels.

公开(公告)号：EP3355874A1

公开(公告)日：2018-08-08

申请号：EP16852605.1

申请日：2016-09-29

申请人： Hoag, George Edward

发明人： Hoag, George Edward

IPC分类号： A61K31/05 ,  A61K31/618 ,  A61K31/165

CPC分类号： A61K31/196 ,  A61K9/0014 ,  A61K9/06 ,  A61K31/045 ,  A61K31/05 ,  A61K31/06 ,  A61K31/192 ,  A61K31/202 ,  A61K31/352 ,  A61K31/405 ,  A61K31/5415 ,  A61K31/618 ,  A61K36/185 ,  A61K36/45 ,  A61K36/53 ,  A61K36/534 ,  A61K36/537 ,  A61K36/55 ,  A61K36/61 ,  A61K45/06 ,  A61K47/26 ,  A61K47/32 ,  A61K47/46 ,  A61K2300/00 ,  A61P25/00 ,  A61P29/00

摘要： This disclosure relates to natural topical and analgesic pain relief and anti-inflammation compositions and methods to reduce pain and inflammation. This disclosure also relates to the use of non-steroidal anti-inflammatory compounds (NSAIDs) in hydrophilic compositions comprised of synthetic and natural plant extract compounds that are multifunctional TRPM8 ion channel agonists, TRPA1 and TRPV1 ion channel antagonists, CGRP antagonists, and COX-2 inhibitors. In particular, this disclosure relates to a topical analgesic composition comprising at least one NSAID, at least one synthetic or natural plant extract TRPM8 agonist, at least one synthetic or natural plant extract is a TRPA1 antagonist, and at least one fixed plant seed oil containing Omega-3 fatty acids TRPV1 antagonists, and a carrier.

公开(公告)号：EP3355864A1

公开(公告)日：2018-08-08

申请号：EP16852272.0

申请日：2016-08-26

申请人： Wellesley Pharmaceuticals, LLC

发明人： DILL, David, A.

IPC分类号： A61K9/16 ,  A61K9/24 ,  A61K9/52

CPC分类号： A61K9/2081 ,  A61K9/5073 ,  A61K9/5084 ,  A61K31/12 ,  A61K31/167 ,  A61K31/192 ,  A61K31/405 ,  A61K31/616 ,  A61K45/06 ,  A61K2300/00

摘要： Methods for manufacturing and using a pharmaceutical composition for reducing the frequency of urination is disclosed. The pharmaceutical composition comprises an analgesic agent and zolpedim.

公开(公告)号：EP3352747A1

公开(公告)日：2018-08-01

申请号：EP16770366.9

申请日：2016-09-08

申请人： Professional Dietetics International S.r.l. in forma abbreviata P.D. INT. S.R.L.

发明人： GIORGETTI, Paolo Luca Maria

IPC分类号： A61K31/198 ,  A61K31/405 ,  A61K31/4172 ,  A61P29/00

CPC分类号： A61K31/198 ,  A61K31/405 ,  A61K31/4172 ,  A61K2300/00

摘要： Amino acids compositions for use in the treatment of pain in patients who underwent elective arthroplasty.

公开(公告)号：EP2968288B1

公开(公告)日：2018-07-04

申请号：EP14770645

申请日：2014-03-10

申请人： MERCK SHARP & DOHME

发明人： PASTERNAK ALEXANDER ,  DING FA-XIANG ,  DONG SHUZHI ,  TANG HAIFENG ,  JIANG JINLONG ,  GU XIN ,  YANG CANGMING ,  BISWAS DIPSHIKHA

IPC分类号： C07D471/10 ,  A61K31/24 ,  A61K31/401 ,  A61K31/403 ,  A61K31/405 ,  A61K31/407 ,  A61K31/41 ,  A61K31/417 ,  A61K31/4178 ,  A61K31/4184 ,  A61K31/435 ,  A61K31/438 ,  A61K45/06 ,  A61P9/12 ,  C07D471/20 ,  C07D498/20

CPC分类号： C07D471/10 ,  A61K31/24 ,  A61K31/401 ,  A61K31/403 ,  A61K31/405 ,  A61K31/407 ,  A61K31/41 ,  A61K31/417 ,  A61K31/4178 ,  A61K31/4184 ,  A61K31/435 ,  A61K31/4422 ,  A61K31/444 ,  A61K31/472 ,  A61K31/4965 ,  A61K31/497 ,  A61K31/4995 ,  A61K31/501 ,  A61K31/506 ,  A61K31/519 ,  A61K31/5386 ,  A61K31/55 ,  A61K31/551 ,  A61K31/554 ,  A61K31/585 ,  A61K31/675 ,  A61K45/06 ,  C07D471/20 ,  C07D498/20 ,  A61K2300/00

摘要： The present invention provides compounds of Formula I and the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir1.1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure and chronic kidney disease and conditions associated with excessive salt and water retention.