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公开(公告)号：EP2621500A2
公开(公告)日：2013-08-07
申请号：EP11830073.0
申请日：2011-10-03
发明人： HERSHBERG, Robert , COUKOS, George , DIETSCH, Gregory , FACCIABENE, Andrea , MANJARREZ, Kristi , RANDALL, Tressa, D.
IPC分类号： A61K31/55 , A61K31/122 , A61K9/127 , A61K9/48 , A61P35/00
CPC分类号： A61K31/55 , A61K9/0019 , A61K9/1271 , A61K31/675 , A61K31/704 , A61K31/7068 , A61K45/06 , A61K47/6951 , B82Y5/00 , A61K2300/00
摘要： The present invention is directed generally to formulations of a TLR agonist preferably a TLR8 agonist, and its use in the treatment of various diseases, including combination therapies for treating cancer.
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公开(公告)号：EP3195868A2
公开(公告)日：2017-07-26
申请号：EP16199830.7
申请日：2011-10-03
发明人： HERSHBERG, Robert , COUKOS, George , DIETSCH, Gregory , FACCIABENE, Andrea , MANJARREZ, Kristi , RANDALL, Tressa D.
IPC分类号： A61K31/55 , A61K31/122 , A61K9/127 , A61K9/48 , A61P35/00 , A61K31/704 , A61K31/7068 , A61K9/00 , A61K31/675 , A61K45/06
CPC分类号： A61K31/55 , A61K9/0019 , A61K9/1271 , A61K31/675 , A61K31/704 , A61K31/7068 , A61K45/06 , A61K47/6951 , B82Y5/00 , A61K2300/00
摘要： The present invention is directed generally to formulations of a TLR agonist preferably a TLR8 agonist, and its use in the treatment of various diseases, including combination therapies for treating cancer.
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公开(公告)号：EP3195868A3
公开(公告)日：2017-08-02
申请号：EP16199830.7
申请日：2011-10-03
发明人： HERSHBERG, Robert , COUKOS, George , DIETSCH, Gregory , FACCIABENE, Andrea , MANJARREZ, Kristi , RANDALL, Tressa D.
IPC分类号： A61K31/55 , A61K31/122 , A61K9/127 , A61K9/48 , A61P35/00 , A61K31/704 , A61K31/7068 , A61K9/00 , A61K31/675 , A61K45/06
CPC分类号： A61K31/55 , A61K9/0019 , A61K9/1271 , A61K31/675 , A61K31/704 , A61K31/7068 , A61K45/06 , A61K47/6951 , B82Y5/00 , A61K2300/00
摘要： The present invention is directed generally to formulations of a TLR agonist preferably a TLR8 agonist, and its use in the treatment of various diseases, including combination therapies for treating cancer.
摘要翻译： 本发明总体上涉及TLR激动剂（优选TLR8激动剂）的制剂，及其在治疗各种疾病（包括用于治疗癌症的联合疗法）中的用途。
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公开(公告)号：EP2621500B1
公开(公告)日：2016-11-23
申请号：EP11830073.0
申请日：2011-10-03
发明人： HERSHBERG, Robert , COUKOS, George , DIETSCH, Gregory , FACCIABENE, Andrea , MANJARREZ, Kristi , RANDALL, Tressa, D.
IPC分类号： A61K31/55 , A61K31/122 , A61K9/127 , A61K9/48 , A61P35/00 , A61K47/48 , A61K31/704 , A61K31/7068 , A61K9/00 , A61K31/675 , A61K45/06
CPC分类号： A61K31/55 , A61K9/0019 , A61K9/1271 , A61K31/675 , A61K31/704 , A61K31/7068 , A61K45/06 , A61K47/6951 , B82Y5/00 , A61K2300/00
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公开(公告)号：EP1987160B1
公开(公告)日：2014-05-14
申请号：EP07709824.2
申请日：2007-01-25
IPC分类号： C12Q1/68 , G01N33/574
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/112
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公开(公告)号：EP2342334A1
公开(公告)日：2011-07-13
申请号：EP09817051.7
申请日：2009-09-29
发明人： COUKOS, George , FACCIABENE, Andrea
IPC分类号： C12N15/09
CPC分类号： A61K39/0011 , A61K41/0057 , A61K48/00 , A61K51/1045 , A61K2039/53 , A61K2039/55516 , A61K2039/58 , A61K2039/62 , C07H21/04 , C07K14/4748 , C07K16/2851 , C07K2317/24 , C07K2319/55
摘要： The present invention provides methods of immunizing a subject against a tumor, inhibiting tumor growth, inhibiting tumor recurrence, treating, suppressing the growth of, or decreasing the incidence of a tumor, overcoming tolerance to a tumor vasculature marker (TVM) in a subject comprising the step of administering a vaccine comprising a TVM or a nucleic acid encoding a TVM and related vaccines. The present invention also provides a method of targeting a tumor vasculature in a subject having a tumor comprising the step of contacting said subject with a labeled compound that binds a) a tumor vasculature marker (TVM) or b) a nucleic acid molecule encoding said TVM.
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公开(公告)号：EP1987160A2
公开(公告)日：2008-11-05
申请号：EP07709824.2
申请日：2007-01-25
IPC分类号： C12Q1/68 , G01N33/574
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/112
摘要： This invention provides methods of detecting and localizing tumor vasculature cells (TVC) and solid tumors; and treating, impeding vascularization of, and determining the stage of solid tumors in a subject, comprising the step of contacting a subject or a TVC with a ligand that binds to a nucleic acid molecule of the present invention, or binds to a protein encoded by the nucleic acid molecule.
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8.发明公开PRODUCER CELLS FOR REPLICATION SELECTIVE VIRUSES IN THE TREATMENT OF MALIGNANCY 审中-公开FOR REPLICATION选择性病毒生产性细胞用于治疗恶性病变
公开(公告)号：EP1061806A1
公开(公告)日：2000-12-27
申请号：EP99911363.2
申请日：1999-03-12
发明人： MOLNAR-KIMBER, Katherine, L. , CAPARRELLI, David J. , KAISER, Larry, R. , ALBELDA, Steven, M. , COUKOS, George
CPC分类号： A61K48/00 , A61K35/763 , C12N2710/16632
摘要： The invention includes producer cells for administering to a subject having tumor cells in order to kill tumor cells or prevent growth or spread of the tumor. The producer cell comprises an oncolytic virus which is capable of replicating in the producer cell. The producer cell is not capable of sustained survival in the body of the subject. The invention also includes methods of using these producer cells to treat a subject having tumor cells and making a medicament for use in such treatment.
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公开(公告)号：EP2665521A2
公开(公告)日：2013-11-27
申请号：EP12736801.7
申请日：2012-01-18
发明人： POWELL, Daniel, J. , COUKOS, George
CPC分类号： C07K16/28 , A61K35/17 , A61K39/0011 , A61K39/39558 , A61K2035/124 , A61K2039/505 , A61K2039/5156 , A61K2039/5158 , C07K14/705 , C07K14/7051 , C07K14/70517 , C07K14/70578 , C07K2317/622 , C07K2318/20 , C07K2319/02 , C07K2319/03 , C07K2319/30 , C07K2319/74
摘要： The invention provides compositions and methods for treating ovarian cancer. Specifically, the invention relates to administering a genetically modified T cell having α-folate receptor (FRα) binding domain and 4-1BB (CD137) costimulatory domain to treat ovarian cancer.
摘要翻译： 本发明提供了用于治疗卵巢癌的组合物和方法。 具体而言，本发明涉及施用具有α-叶酸受体（FRα）结合结构域和4-IBB（CD137）共刺激结构域的遗传修饰的T细胞来治疗卵巢癌。
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