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公开(公告)号：EP2752417B1
公开(公告)日：2017-05-31
申请号：EP14001216.2
申请日：2006-04-11
发明人： Chafeev, Mikhail , Chowdhury, Sultan , Fraser, Robert , Fu, Jian-Min , Kamboj, Rajender , Hou, Duanjie , Liu, Shifeng , Bagherzadeh, Mehran Seid , Sviridov, Serguei , Sun, Shaoyi , Sun, Jianyu , Chakka, Nagasree , Hsieh, Tom , Raina, Vandna
IPC分类号： C07D498/10 , A61K31/404 , A61P29/00
CPC分类号： C07D491/10
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2.发明公开Heterocyclic derivatives and their use as stearoyl-coa desaturase inhibitors 审中-公开杂环衍生物及其作为硬脂酰 - 鲨去饱和酶抑制剂的用途
公开(公告)号：EP2266569A3
公开(公告)日：2011-03-09
申请号：EP10013035.0
申请日：2005-09-20
发明人： Kamboj, Rajender , Zhang, Zaihui , Fu, Jian-Min , Kodumuru, Vishnumurthy , Sviridov, Serguei , Sadalapure, Kashinath , Liu, Shifeng , Sun, Shaoyi , Hou, Duanjie , Chakka, Nagasree
IPC分类号： A61K31/501 , A61K31/496 , A61P3/00 , A61P3/04 , A61P3/10 , A61P3/06 , A61P1/16 , C07D403/00
CPC分类号： A61K31/496 , A61K31/501
摘要： Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I):
where x, y, G, J, K, L, M, V R 2 , R 3 , R 4 , R 5 , R 5a , R 6 , R 6a , R 7 , R 7a , R 8 and R 8a are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.摘要翻译： 公开了治疗哺乳动物，优选人的SCD介导的疾病或病症的方法，其中所述方法包括向需要其的哺乳动物施用式（I）的化合物：其中x，y，G，J，K ，L，M，V R2，R3，R4，R5，R5a，R6，R6a，R7，R7a，R8和R8a如本文所定义。 还公开了包含式（I）化合物的药物组合物。
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3.发明公开Heterocyclic derivatives and their use as stearoyl-coa desaturase inhibitors 审中-公开Heterozyklische Derivate und ihre Verwendung als Stearoyl-Coa-Desaturase-Inhibitoren
公开(公告)号：EP2266569A2
公开(公告)日：2010-12-29
申请号：EP10013035.0
申请日：2005-09-20
发明人： Kamboj, Rajender , Zhang, Zaihui , Fu, Jian-Min , Kodumuru, Vishnumurthy , Sviridov, Serguei , Sadalapure, Kashinath , Liu, Shifeng , Sun, Shaoyi , Hou, Duanjie , Chakka, Nagasree
IPC分类号： A61K31/501 , A61K31/496 , A61P3/00 , A61P3/04 , A61P3/10 , A61P3/06 , A61P1/16 , C07D403/00
CPC分类号： A61K31/496 , A61K31/501
摘要： Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I):
where x, y, G, J, K, L, M, V R 2 , R 3 , R 4 , R 5 , R 5a , R 6 , R 6a , R 7 , R 7a , R 8 and R 8a are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.摘要翻译： 公开了在哺乳动物，优选人中治疗SCD介导的疾病或病症的方法，其中所述方法包括向有需要的哺乳动物施用式（I）化合物：其中x，y，G，J，K ，L，M，VR 2，R 3，R 4，R 5，R 5a，R 6，R 6a，R 7，R 7a，R 8和R 8a。 还公开了包含式（I）化合物的药物组合物。
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4.发明公开
公开(公告)号：EP3241834A1
公开(公告)日：2017-11-08
申请号：EP17000910.4
申请日：2006-04-11
发明人： Chafeev, Mikhail , Chowdhury, Sultan , Fraser, Robert , Fu, Jian-Min , Kamboj, Rajender , Hou, Duanjie , Liu, Shifeng , Bagherzadeh, Mehran Seid , Sviridov, Serguei , Sun, Shaoyi , Sun, Jianyu , Chakka, Nagasree , Hsieh, Tom , Raina, Vandna
IPC分类号： C07D498/10 , A61K31/404 , A61P29/00
CPC分类号： C07D491/10
摘要： This invention is directed to spiro-oxindole compounds of formula (I):
wherein k, j, Q, R 1 , R 2a , R 2b , R 2c , R 2d , R 3a , R 3b , R 3c , and R 3d are as defined herein, as a stereoisomer, enantiomer, tautomer thereof or mixtures thereof; or a pharmaceutically acceptable salt, solvate or prodrug thereof, which are useful for the treatment and/or prevention of sodium channel-mediated diseases or conditions, such as pain. Pharmaceutical compositions comprising the compounds and methods of preparing and using the compounds are also disclosed.摘要翻译： 本发明涉及式（I）的螺 - 羟吲哚化合物：其中k，j，Q，R1，R2a，R2b，R2c，R2d，R3a，R3b，R3c和R3d如本文所定义， ，其互变异构体或其混合物; 或其药学上可接受的盐，溶剂化物或前药，其可用于治疗和/或预防钠通道介导的疾病或病症如疼痛。 还公开了包含所述化合物的药物组合物以及制备和使用所述化合物的方法。
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5.发明公开PYRIDAZINE DERIVATIVES AND THEIR USE AS THERAPEUTIC AGENTS 审中-公开PYRIDAZINDERIVATE UND DEREN VERWENDUNG ALS THERAPEUTISCHE WIRKSTOFFE
公开(公告)号：EP3042895A1
公开(公告)日：2016-07-13
申请号：EP16000190.5
申请日：2004-07-29
发明人： Abreo, Melwyn , Chafev, Mikhail , Chakka, Nagasree , Chowdhury, Sultan , FU, Jian-Min , Gschwend, Heinz W. , Holladay, Mark W. , HOU, Duanjie , Kamboj, Rajender , Kodumuru, Vishnumurthy , LI, Wenbao , LIU, Shifeng , Raina, Vandna , SUN, Sengen , SUN, Shaoyi , Sviridov, Serguei , TU, Chi , Winther, Michael D. , Zhang, Zaihui
IPC分类号： C07D237/20 , C07D237/22 , A61K31/501 , A61P3/06
CPC分类号： A61K31/00 , A61K31/501 , A61K31/551 , C07D237/20 , C07D237/24
摘要： Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I):
where x, y, W, V, R 2 , R 3 , R 4 , R 5 , R 6 , R 6a , R 7 , R 7a , R 8 , R 8a , R 9 and R 9a are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.摘要翻译： 公开了治疗哺乳动物，优选人类的SCD介导的疾病或病症的方法，其中所述方法包括向有需要的哺乳动物施用式（I）化合物：其中x，y，W，V，R 2，R 3，R 4，R 5，R 6，R 6a，R 7，R 7a，R 8，R 8a，R 9和R 9a如本文所定义。 还公开了包含式（I）化合物的药物组合物。
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公开(公告)号：EP2316827A1
公开(公告)日：2011-05-04
申请号：EP10184939.6
申请日：2004-07-29
发明人： Abreo, Melwyn , Chafev, Mikhail , Chakka, Nagasree , Chowdhury, Sultan , Fu, Jian-Min , Gschwend, Heinz, W. , Holladay, Mark, W. , Hou, Duanjie , Kamboj, Rajender , Kodumuru, Vishnumurthy , Li, Wenbao , Liu, Shifeng , Raina, Vandna , Sun, Sengen , Sun, Shaoyi , Sviridov, Serguei , Tu, Chi , Winther, Michael, D. , Zhang, Zaihui
IPC分类号： C07D237/20 , C07D237/24 , A61K31/501 , A61P3/06
CPC分类号： A61K31/00 , A61K31/501 , A61K31/551 , C07D237/20 , C07D237/24
摘要： Compounds for treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the compounds are of formula (I):
where x y, W, V, R 2 , R 3 , R 4 , R 5 , R 6 , R 6a , R 7 , R 7a , R 8 , R 8a , R 9 and R 9a are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.摘要翻译： 公开了用于治疗哺乳动物，优选人的SCD介导的疾病或病症的化合物，其中所述化合物具有式（I）：其中xy，W，V，R2，R3，R4，R5，R6，R6a， R7，R7a，R8，R8a，R9和R9a如本文所定义。 还公开了包含式（I）化合物的药物组合物。
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7.发明公开Heterocyclic derivatives for the treatment of diseases mediated by stearoyl-coa desaturase enzymes 审中-公开Heterozyklische Derivate zur Behandlung von durch硬脂酰辅酶脱氢酶 - 酶verrachtenten Krankheiten
公开(公告)号：EP2289510A1
公开(公告)日：2011-03-02
申请号：EP10011738.1
申请日：2005-09-20
发明人： Kamboj, Rajender , Zhang, Zaihui , Fu, Jian-Min , Kodumuru, Vishnumurthy , Liu, Shifeng , Sun, Shaoyi , Chakka, Nagasree
IPC分类号： A61K31/381 , A61K31/41 , A61K31/415 , C07D285/00 , C07D271/10 , C07D231/38 , C07D277/28 , A61P3/04
CPC分类号： C07D277/28 , A61K31/381 , A61K31/41 , A61K31/415 , C07D231/38 , C07D271/113 , C07D285/01
摘要： Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I):
where x, y, G, J, K, L, M, W, V, R 2 , R 3 , R 5 , R 5a , R 6 , R 6a , R 7 , R 7a , R 8 and R 8a are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.摘要翻译： 公开了在哺乳动物，优选人中治疗SCD介导的疾病或病症的方法，其中所述方法包括向有需要的哺乳动物施用式（I）化合物：其中x，y，G，J，K ，L，M，W，V，R 2，R 3，R 5，R 5a，R 6，R 6a，R 7，R 7a，R 8和R 8a。 还公开了包含式（I）化合物的药物组合物。
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公开(公告)号：EP2316827B1
公开(公告)日：2016-01-27
申请号：EP10184939.6
申请日：2004-07-29
发明人： Abreo, Melwyn , Chafev, Mikhail , Chakka, Nagasree , Chowdhury, Sultan , Fu, Jian-Min , Gschwend, Heinz, W. , Holladay, Mark, W. , Hou, Duanjie , Kamboj, Rajender , Kodumuru, Vishnumurthy , Li, Wenbao , Liu, Shifeng , Raina, Vandna , Sun, Sengen , Sun, Shaoyi , Sviridov, Serguei , Tu, Chi , Winther, Michael, D. , Zhang, Zaihui
IPC分类号： C07D237/20 , C07D237/24 , A61K31/501 , A61P3/06
CPC分类号： A61K31/00 , A61K31/501 , A61K31/551 , C07D237/20 , C07D237/24
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公开(公告)号：EP2428515A1
公开(公告)日：2012-03-14
申请号：EP11009687.2
申请日：2006-04-11
发明人： Chafeev, Mikhail , Chowdhury, Sultan , Fraser, Robert , Fu, Jinamin , Kamboj, Rajender , Hou, Duanjie , Liu, Shifeng , Bagherzadeh, Mehran Seid , Sviridov, Serguei , Sun, Shaoyi , Sun, Jianyu , Chakka, Nagasree , Hsieh, Tom , Raina, Vandna
IPC分类号： C07D498/10 , A61K31/404 , A61P29/00
CPC分类号： C07D491/10
摘要： This invention is directed to spiro-oxindole compounds of formula (I):
wherein k, j, Q, R 1 , R 2a , R 2b , R 2c , R 2d , R 3a , R 3b , R 3c , and R 3d are as defined herein, as a stereoisomer, enantiomer, tautomer thereof or mixtures thereof; or a pharmaceutically acceptable salt, solvate or prodrug thereof, which are useful for the treatment and/or prevention of sodium channel-mediated diseases or conditions, such as pain. Pharmaceutical compositions comprising the compounds and methods of preparing and using the compounds are also disclosed.摘要翻译： 本发明涉及式（I）的螺 - 羟吲哚化合物：其中k，j，Q，R 1，R 2a，R 2b，R 2c，R 2d，R 3a，R 3b，R 3c和R 3d为 如本文定义的立体异构体，对映异构体，互变异构体或其混合物; 或其药学上可接受的盐，溶剂化物或前药，其可用于治疗和/或预防钠通道介导的疾病或病症，例如疼痛。 还公开了包含该化合物的药物组合物和制备和使用该化合物的方法。
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公开(公告)号：EP2316826A1
公开(公告)日：2011-05-04
申请号：EP10184440.5
申请日：2004-07-29
IPC分类号： C07D237/20 , C07D237/22 , A61K31/501 , A61P3/06
CPC分类号： C07D213/75 , A61K31/00 , A61K31/501 , A61K31/551 , C07D213/76 , C07D213/81 , C07D237/20 , C07D237/22
摘要： Compounds for treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the compounds are of formula (I):
where x, y, W, V, R 2 , R 3 , R 4 , R 5 , R 6 , R 6a , R 7 , R 7a , R 8 , R 8a , R 9 and R 9a are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.摘要翻译： 公开了用于治疗哺乳动物，优选人类中SCD介导的疾病或病症的化合物，其中所述化合物具有式（I）：其中x，y，W，V，R 2，R 3，R 4，R 5，R 6，R 6a，R 7，R 7a，R 8，R 8a，R 9和R 9a如本文所定义。 还公开了包含式（I）化合物的药物组合物。
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