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公开(公告)号：EP4389764A2
公开(公告)日：2024-06-26
申请号：EP24161280.3
申请日：2013-11-05
申请人： Regeneron Pharmaceuticals, Inc. , Yale University , Institute for Research in Biomedicine (IRB)
发明人： FLAVELL, Richard , STROWIG, Till , MANZ, Markus G. , BORSOTTI, Chiara , DHODAPKAR, Madhav , MURPHY, Andrew J. , STEVENS, Sean , YANCOPOULOS, George D.
IPC分类号： C07K14/535
CPC分类号： C07K14/535 , C07K14/5403 , C07K14/5412 , A01K2217/05220130101 , A01K2217/07220130101 , A01K2217/1520130101 , A01K2227/10520130101 , C07K14/524 , A01K2267/0120130101 , A01K67/0278 , A61K49/0008
摘要： Genetically modified non-human animals are provided that may be used to model human hematopoietic cell development, function, or disease. The genetically modified non-human animals comprise a nucleic acid encoding human IL-6 operably linked to an IL-6 promoter. In some instances, the genetically modified non-human animal expressing human IL-6 also expresses at least one of human M-CSF, human IL-3, human GM-CSF, human SIRPa or human TPO. In some instances, the genetically modified non-human animal is immunodeficient. In some such instances, the genetically modified non-human animal is engrafted with healthy or diseased human hematopoietic cells. Also provided are methods for using the subject genetically modified non-human animals in modeling human hematopoietic cell development, function, and/or disease, as well as reagents and kits thereof that find use in making the subject genetically modified non-human animals and/or practicing the subject methods.
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公开(公告)号：EP4403642A2
公开(公告)日：2024-07-24
申请号：EP24175675.8
申请日：2018-04-03
发明人： TAGLIATELA, Stephanie , YOUNG, Andrew , CHEN, Szu-Ying , RAMAMOORTHI, Kartik , OBERKOFLER, David
IPC分类号： C12Q1/68
CPC分类号： A01K2217/05220130101 , A01K2217/1520130101 , A01K2227/10520130101 , A01K2267/031220130101 , C07K14/705 , C12N15/86 , A61K48/0058 , C12N2840/00720130101 , A61P25/28 , A61P25/08 , A61K48/00 , C12N2750/1414320130101
摘要： Provided herein are compositions and methods for selective expression of a transgene. Compositions and methods for selective expression of a transgene comprise one or more human regulatory elements, which, when operably linked to a transgene, can facilitate selective expression of a transgene (e.g., cell-type selective expression) in a target cell as compared to at least one or more non-target cells.
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公开(公告)号：EP4345163A3
公开(公告)日：2024-06-19
申请号：EP24156172.9
申请日：2011-03-31
申请人： Ablexis, LLC
发明人： GREEN, Larry , SHIZUYA, Hiroaki
IPC分类号： A01K67/0275 , C07K16/00 , C07K16/18 , C07K16/46 , C12N15/85
CPC分类号： A01K2217/05220130101 , A01K2267/0120130101 , C07K2317/2420130101 , C12N2510/0220130101 , A01K67/0275 , C07K16/00 , A01K2227/10520130101 , A01K2217/07220130101 , A01K2207/1520130101
摘要： The invention provides A mouse whose genome comprises a transgene comprising a polynucleotide sequence comprising DNA sequences corresponding to DNA sequences from a mouse immunoglobulin locus except for polynucleotide sequences encoding one or more human immunoglobulin light chain variable (V) polypeptide sequences and one or more human immunoglobulin light chain joining (J) polypeptide sequences, wherein the sequences encoding the one or more human light chain V polypeptide sequences and the one or more human light chain J polypeptide sequences replace one or more mouse immunoglobulin light chain V coding sequences and one or more mouse immunoglobulin light chain J coding sequences, respectively.
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公开(公告)号：EP3871498B1
公开(公告)日：2024-09-25
申请号：EP21169076.3
申请日：2010-07-07
IPC分类号： A01K67/0278 , C07K16/00 , C07K16/46 , C12N15/85 , A61P37/02
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5.发明公开
公开(公告)号：EP4429676A2
公开(公告)日：2024-09-18
申请号：EP22890879.4
申请日：2022-11-07
申请人： Memorial Sloan Kettering Cancer Center , Sloan-Kettering Institute for Cancer Research , Memorial Hospital for Cancer and Allied Diseases
发明人： KESHARI, Kayvan R. , PERRY, Justin
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公开(公告)号：EP4345164A3
公开(公告)日：2024-06-26
申请号：EP24156173.7
申请日：2011-03-31
申请人： Ablexis, LLC
发明人： GREEN, Larry , SHIZUYA, Hiroaki
IPC分类号： A01K67/0275 , C07K16/00 , C07K16/18 , C07K16/46 , C12N15/85
CPC分类号： A01K2217/05220130101 , A01K2267/0120130101 , C07K2317/2420130101 , C12N2510/0220130101 , A01K67/0275 , C07K16/00 , A01K2227/10520130101 , A01K2217/07220130101 , A01K2207/1520130101
摘要： The invention provides a mouse whose genome comprises a transgene comprising a polynucleotide sequence comprising DNA sequences corresponding to DNA sequences from a mouse immunoglobulin locus except for polynucleotide sequences encoding one or more human immunoglobulin heavy chain variable (V) polypeptide sequences, one or more human immunoglobulin heavy chain diversity (D) polypeptide sequences, and one or more human immunoglobulin heavy chain joining (J) polypeptide sequences, wherein the polynucleotide sequences encoding the one or more human heavy chain V polypeptide sequences, the one or more human heavy chain D polypeptide sequences, and the one or more human heavy chain J polypeptide sequences replace one or more mouse immunoglobulin heavy chain V coding sequences, one or more mouse immunoglobulin heavy chain D coding sequences, and one or more mouse immunoglobulin heavy chain J coding sequences, respectively.
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公开(公告)号：EP3888457B1
公开(公告)日：2024-05-15
申请号：EP21169074.8
申请日：2010-07-07
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公开(公告)号：EP4403642A3
公开(公告)日：2024-10-09
申请号：EP24175675.8
申请日：2018-04-03
发明人： TAGLIATELA, Stephanie , YOUNG, Andrew , CHEN, Szu-Ying , RAMAMOORTHI, Kartik , OBERKOFLER, David
IPC分类号： C12N15/63 , A01K67/027 , C12Q1/68
CPC分类号： A01K2217/05220130101 , A01K2217/1520130101 , A01K2227/10520130101 , A01K2267/031220130101 , C07K14/705 , C12N15/86 , A61K48/0058 , C12N2840/00720130101 , A61P25/28 , A61P25/08 , A61K48/00 , C12N2750/1414320130101
摘要： Provided herein are compositions and methods for selective expression of a transgene. Compositions and methods for selective expression of a transgene comprise one or more human regulatory elements, which, when operably linked to a transgene, can facilitate selective expression of a transgene (e.g., cell-type selective expression) in a target cell as compared to at least one or more non-target cells.
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公开(公告)号：EP4389211A3
公开(公告)日：2024-08-28
申请号：EP24157959.8
申请日：2020-04-30
CPC分类号： C07K14/47 , A61K38/1709 , C12N2750/1414320130101 , A01K2217/05220130101 , A01K2227/10520130101 , A01K2267/039320130101 , A61K48/005 , A01K2207/2020130101 , C07K2319/3020130101 , A61P9/00 , A61P9/04
摘要： A protein selected from the group consisting of Chrdl1, Fam3c, Fam3b and a fragment thereof, or a polynucleotide encoding therefor, for use in treating or reducing the risk of heart disease.
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公开(公告)号：EP4014729B1
公开(公告)日：2024-08-07
申请号：EP22155461.1
申请日：2010-07-07
IPC分类号： A01K67/0278 , A61P37/02 , C07K16/00 , C07K16/46 , C12N15/85
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