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公开(公告)号：EP4417255A2
公开(公告)日：2024-08-21
申请号：EP24166565.2
申请日：2014-11-21
发明人： YU, Paul , GRINBERG, Asya , SAKO, Dianne S. , CASTONGUAY, Roselyne , STEEVES, Rita , KUMAR, Ravindra
IPC分类号： A61P11/00
CPC分类号： C07K14/71 , C07K2319/3020130101 , A61K38/179 , A61P11/00 , A61P9/00 , A61P9/12
摘要： In some aspects, the invention teaches pharmaceutical compositions that include a TGF-β ligand trap, and methods of using a TGF-β ligand trap to treat, prevent, or reduce the progression rate of pulmonary hypertension (PH). The invention also provides methods of using a TGF-β ligand trap to treat, prevent, or reduce the progression rate of a variety of conditions including, but not limited to, pulmonary vascular remodeling, pulmonary fibrosis, right ventricular hypertrophy, diseases associated with excessive TGF-β signaling, diseases associated with excessive GDF15 signaling, and diseases associated with excessive PAI-1 signaling. The invention further provides methods of using a TGF-β ligand trap to reduce right ventricular systolic pressure in a subject.
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公开(公告)号：EP4375668A3
公开(公告)日：2024-08-14
申请号：EP24164321.2
申请日：2018-11-16
发明人： MELTON WITT, Jody , SON, Sodany , BAUMEISTER, Mark , BERRY, Jody
IPC分类号： C07K14/155 , A61K39/21 , C12N15/49 , C12N5/10 , G01N33/543
CPC分类号： A61K39/12 , C07K14/005 , C07K2319/0220130101 , C07K2319/3020130101 , C07K2319/4020130101 , C07K2319/7320130101 , C12N2740/1612220130101 , C12N2740/1613420130101
摘要： Various embodiments of the invention relate to polypeptides comprising 1-10 or more epitopes of the HIV envelope protein and a fusion protein, wherein the polypeptide lacks the transmembrane domain of the HIV gp41 protein. Such polypeptides may be expressed in mammalian cells, such as human cells, to produce, for example, polypeptides that are useful in developing novel anti-HIV antibodies. Polypeptides described herein and novel antibodies developed therefrom are generally useful for medical diagnostics, and they may also be useful in the prophylactic and therapeutic treatment of HIV.
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公开(公告)号：EP4410378A2
公开(公告)日：2024-08-07
申请号：EP24162480.8
申请日：2017-06-30
IPC分类号： A61P37/02
CPC分类号： C12Y301/21001 , C07K2317/7220130101 , C07K2319/3020130101 , C12Y301/27005 , A61K38/00 , C12N9/22 , A61P1/00 , A61P1/04 , A61P1/16 , A61P15/00 , A61P17/00 , A61P19/02 , A61P21/00 , A61P25/00 , A61P27/02 , A61P29/00 , A61P31/04 , A61P3/10 , A61P37/02 , A61P7/00 , A61P7/06 , A61P9/00
摘要： The invention provides for optimized binuclease fusion proteins with increased pharmacokinetic properties. The optimized binuclease fusion proteins of the invention two or more nuclease domains (e.g., RNase and DNase domain) operably coupled to an Fc domain. The invention also provides methods of treating or preventing a condition associated with an abnormal immune response.
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公开(公告)号：EP4408868A1
公开(公告)日：2024-08-07
申请号：EP22874224.3
申请日：2022-05-13
发明人： LI, Qufei , BAILEY, Lucas
IPC分类号： C07K14/525 , C07K16/00 , C07K19/00 , C12N15/28 , A61K38/19
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公开(公告)号：EP4405397A1
公开(公告)日：2024-07-31
申请号：EP22872129.6
申请日：2022-09-23
发明人： LIANG, Peng
IPC分类号： C07K16/46 , C07K14/705 , A61K35/17 , C07K16/28
CPC分类号： A61P7/04 , C12N15/62 , C12N15/86 , C07K14/524 , C07K2319/0020130101 , C07K14/7151 , C07K2319/3020130101 , A61K38/00 , A61K35/17
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7.发明公开
公开(公告)号：EP4405379A1
公开(公告)日：2024-07-31
申请号：EP22873925.6
申请日：2022-09-26
申请人： Synergy Imt, Inc.
IPC分类号： C07K14/435 , A61P35/00 , C07K16/18
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公开(公告)号：EP3927365B1
公开(公告)日：2024-07-31
申请号：EP20715521.9
申请日：2020-02-21
IPC分类号： A61K38/17 , C07K14/705 , G01N33/50 , G01N33/53
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公开(公告)号：EP4324519A3
公开(公告)日：2024-07-24
申请号：EP23214927.8
申请日：2016-06-29
CPC分类号： A61K38/26 , A61K38/28 , A61K38/2264 , A61K38/2278 , A61K47/60 , A61K47/68 , C07K14/605 , A61P3/04 , A61P3/10 , C07K2319/3020130101
摘要： The present invention relates to a glucagon derivative, a long-acting conjugate of the glucagon derivative, and a use thereof.
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