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公开(公告)号：EP3865581B1
公开(公告)日：2024-09-25
申请号：EP21157152.6
申请日：2012-08-03
IPC分类号： C12N15/85 , A01K67/027 , C12N9/64 , C07K16/46
CPC分类号： C07K16/00 , C07K16/2833 , C07K16/40 , C12N9/6489 , C12N15/8509 , A01K2207/1520130101 , A01K2217/07220130101 , A01K2217/1520130101 , A01K2227/10520130101 , A01K2267/0120130101 , C07K2317/2120130101 , C07K2317/2420130101 , C07K2317/51520130101 , C07K2317/7620130101 , C07K2317/9220130101 , C07K2319/3020130101 , C12N2800/20420130101 , C12N2800/3020130101 , A01K67/0278
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2.发明公开
公开(公告)号：EP4426267A1
公开(公告)日：2024-09-11
申请号：EP22813973.9
申请日：2022-11-04
发明人： GABISON, Eric
CPC分类号： A61P27/02 , A61K35/28 , A61K9/0048 , A61K9/1271 , C12N2740/1604320130101 , C12N15/88 , A61K48/005 , A61K48/0041 , A01K2227/10520130101 , A01K2217/07220130101 , A01K2267/0320130101
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公开(公告)号：EP4410986A2
公开(公告)日：2024-08-07
申请号：EP24178098.0
申请日：2018-07-05
申请人： Kymab Limited
IPC分类号： C12N15/85
CPC分类号： A01K67/0276 , A01K67/0278 , C07K2317/9220130101 , A01K67/027 , C07K16/00 , A01K2217/07220130101 , A01K2217/07520130101 , A01K2217/1520130101 , A01K2227/10520130101 , A01K2267/0120130101 , C07K2317/2120130101 , C07K2317/2420130101 , C07K2317/3120130101 , C07K2317/51520130101 , C07K2317/5520130101 , C07K2317/1420130101
摘要： The invention relates to cells and non-human vertebrates for producing antibody chains (eg, truly common L or H chains), in particular for use in producing multi-specific antibodies useful for therapy or diagnosis.
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公开(公告)号：EP3562944B1
公开(公告)日：2024-07-10
申请号：EP17888225.4
申请日：2017-12-29
IPC分类号： A01K67/0278 , C07K14/47 , C12N15/11 , C12N15/90
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公开(公告)号：EP4345164A3
公开(公告)日：2024-06-26
申请号：EP24156173.7
申请日：2011-03-31
申请人： Ablexis, LLC
发明人： GREEN, Larry , SHIZUYA, Hiroaki
IPC分类号： A01K67/0275 , C07K16/00 , C07K16/18 , C07K16/46 , C12N15/85
CPC分类号： A01K2217/05220130101 , A01K2267/0120130101 , C07K2317/2420130101 , C12N2510/0220130101 , A01K67/0275 , C07K16/00 , A01K2227/10520130101 , A01K2217/07220130101 , A01K2207/1520130101
摘要： The invention provides a mouse whose genome comprises a transgene comprising a polynucleotide sequence comprising DNA sequences corresponding to DNA sequences from a mouse immunoglobulin locus except for polynucleotide sequences encoding one or more human immunoglobulin heavy chain variable (V) polypeptide sequences, one or more human immunoglobulin heavy chain diversity (D) polypeptide sequences, and one or more human immunoglobulin heavy chain joining (J) polypeptide sequences, wherein the polynucleotide sequences encoding the one or more human heavy chain V polypeptide sequences, the one or more human heavy chain D polypeptide sequences, and the one or more human heavy chain J polypeptide sequences replace one or more mouse immunoglobulin heavy chain V coding sequences, one or more mouse immunoglobulin heavy chain D coding sequences, and one or more mouse immunoglobulin heavy chain J coding sequences, respectively.
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6.发明公开
公开(公告)号：EP4374916A2
公开(公告)日：2024-05-29
申请号：EP23219513.1
申请日：2016-03-30
申请人： MedImmune Limited
发明人： COHEN, Emma, S , LOWE, David, C , BUTLER, Robin , SCOTT, Ian, C , VOUSDEN, Katherine, A , STRAIN, Martin, D , CARMEN, Sara , ENGLAND, Elizabeth, H , KEMP, Benjamin, P , REES, David, G , OVERED-SAYER, Catherine, L , MUSTELIN, Tomas, M , SLEEMAN, Matthew , HOUSLAY, Kirsty
IPC分类号： A61P11/06
CPC分类号： C07K14/54 , C07K16/244 , A61K2039/50520130101 , C07K2317/2120130101 , C07K2317/3320130101 , C07K2317/3420130101 , C07K2317/56520130101 , C07K2317/56720130101 , C07K2317/62220130101 , C07K2317/7620130101 , C07K2317/9220130101 , C07K2319/3020130101 , A01K67/0278 , A01K2217/07220130101 , A01K2227/10520130101 , A01K2267/0320130101 , A61P11/06
摘要： The present invention provides isolated IL-33 proteins, active fragments thereof and antibodies, antigen binding fragments thereof, against IL-33 proteins. Also provided are methods of modulating cytokine activity, e.g., for the purpose of treating immune and inflammatory disorders.
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7.发明公开
公开(公告)号：EP4436586A1
公开(公告)日：2024-10-02
申请号：EP22896792.3
申请日：2022-11-21
IPC分类号： A61K35/30 , C12Q1/6883
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8.发明公开
公开(公告)号：EP4328319A3
公开(公告)日：2024-08-07
申请号：EP23200884.7
申请日：2017-10-27
发明人： Oliver, Trudy , Sos, Martin , Wechsler-Reya, Rob
IPC分类号： A01K67/027 , C12N15/09 , C12Q1/02 , A01K67/0278 , A61P35/00 , A61P43/00 , C12Q1/6886 , G01N33/574
CPC分类号： G01N33/57423 , G01N2800/5220130101 , C12Q1/6886 , C12Q2600/10620130101 , C12Q2600/11220130101 , C12Q2600/15820130101 , A01K67/0278 , A01K2217/07220130101 , A01K2217/07520130101 , A01K2217/20620130101 , A01K2227/10520130101 , A01K2267/033120130101 , C12N2999/00720130101 , A61P35/00 , A61P43/00
摘要： Described herein are methods and compositions useful in detecting, diagnosing and treating small cell lung cancer. Transgenic animal models and cell lines are disclosed for the study of a small cell lung cancer subtype. Methods of screening and identifying active agents for the treatment of a small cell lung cancer subtype as well as methods of identifying patients susceptible to treatment with aurora kinase inhibitors are also provided.
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9.发明公开
公开(公告)号：EP4356727A3
公开(公告)日：2024-07-24
申请号：EP24160383.6
申请日：2019-04-05
IPC分类号： A61K48/00 , C12N15/86 , C07K14/47 , A01K67/0278
CPC分类号： C07K14/4728 , A01K67/0278 , A01K2217/07220130101 , A01K2227/10520130101 , A01K2267/030620130101 , A61K48/005 , A61K48/0058 , C12N15/86 , C12N2750/1414320130101 , C12N2830/00820130101 , C12N2830/4820130101 , C12N2840/20320130101
摘要： The disclosure features compositions and methods for the treatment of catecholaminergic polymorphic ventricular tachycardia (CPVT), particularly forms of the disease that are inherited in an autosomal dominant manner, by way of calsequestrin 2 (CASQ2) gene therapy. The compositions and methods described herein can be used to treat CPVT caused by mutations in, for example, ryanodine receptor 2 and calmodulin, such as calmodulin 1 (CALM1) and CALMS. The disclosure provides a variety of vectors that can be used for the delivery of a CASQ2 transgene to a patient, such as a human patient suffering from autosomal dominant CPVT, including adeno-associated virus vectors, among others.
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公开(公告)号：EP3725879B1
公开(公告)日：2024-07-03
申请号：EP18887944.9
申请日：2018-12-06
IPC分类号： A01K67/0275 , C12N9/02
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