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公开(公告)号：EP1589881A1
公开(公告)日：2005-11-02
申请号：EP04703835.1
申请日：2004-01-21
发明人： BARKER, Stephen G.E.,The Academic Vascular Unit , HOLLINGSWORTH, S.J.,The Academic Vascular Unit
IPC分类号： A61B17/122
CPC分类号： A61B17/122 , A61B17/1222 , A61B17/1285 , A61B2017/00907
摘要： A surgical clip (5) is provided for clipping a tubular structure (9) in vivo to ligate the tubular structure. The clip comprises first and second clip portions (6, 7). A hinge portion (8) is provided connecting the clip portions together and to enable the clip portions to be hinged together from an open clip condition to a closed clip condition thereby to ligate a tubular structure placed between the clip portions. A lock is provided for locking the clip portions together in the closed clip condition. In the closed clip condition the clip has a substantially smooth external profile, for example including blunt ends (21), so as to reduce the possibility of the clip (in use) eroding surrounding tissue structures.
摘要翻译： 提供手术夹子（5）用于在体内夹住管状结构（9）以结扎管状结构。 夹子包括第一和第二夹子部分（6,7）。 提供了铰链部分（8），其将夹子部分连接在一起并且使得夹子部分能够从打开的夹子状态铰接在一起到闭合的夹子状态，从而结合放置在夹子部分之间的管状结构。 提供锁定用于在闭合的夹子状态下将夹子部分锁定在一起。 在闭合的夹子状态下，夹子具有基本光滑的外部轮廓，例如包括钝端（21），以便减少夹子（在使用中）侵蚀周围组织结构的可能性。
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公开(公告)号：EP1492875A1
公开(公告)日：2005-01-05
申请号：EP03718934.7
申请日：2003-04-11
IPC分类号： C12N15/86
CPC分类号： C12N15/86 , A61K35/13 , A61K48/00 , C12N2710/16643 , C12N2750/14143
摘要： The present invention provides the use of a replication competent herpes virus which (a) lacks a functional wild-type HSV ICP27 gene; and (b) comprises an ICP27 gene encoding an ICP27 protein which allows replication of said herpes virus to occur and which has a reduced ability to inhibit RNA splicing compared to wild-type HSV ICP27 in the production of an adeno-associated virus (AAV) vector.
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公开(公告)号：EP1472555A2
公开(公告)日：2004-11-03
申请号：EP03701609.4
申请日：2003-01-28
IPC分类号： G01R33/54
CPC分类号： G01R33/54
摘要： Magnetic resonance images are acquired by combining images obtained using two different spatial sensitivity profiles, (1’), (2’). The transverse magnetisation is caused to adopt such a profile (1’) in one direction, resulting, in two dimensions, to a series of alternating stripes of respectively strong and weak, e.g. zero, transverse magnetisation. The regions of strong transverse magnetisation correspond to regions of high sensitivity in the acquired image. A complementary sensitivity profile (2’) is stored as longitudinal magnetisation. A first image is then acquired in which the pixels are centered on the regions of high sensitivity within the first sensitivity profile (1’). The complementary sensitivity profile (2’) is then recalled by inserting an additional gradient pulse and then a radio-frequency pulse into the pulse sequence and a second image acquired. As with the first image, the pixels are centered on the high-sensitivity regions, but these are mid-way between those within the first sensitivity profile (1’). A combined image is then created by interleaving the two images. The combined image has twice the resolution of each of the two component images. In a further embodiment, two images are acquired in which each spatial sensitivity profile exhibits a sinusoidal profile extending over the field of view. In this case, all the data from the two images are combined using an algorithm.
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公开(公告)号：EP0700441B1
公开(公告)日：2004-08-25
申请号：EP94915674.9
申请日：1994-05-24
发明人： GARSON, Jeremy, Univ. College London Med. School , TUKE, Philip, Univ. College London Med. School
IPC分类号： C12N15/48 , G01N33/68 , G01N33/569 , C12Q1/68 , C12P21/08 , G01N33/577
CPC分类号： C07K14/005 , C12N2740/10022
摘要： The present invention provides a polynucleotide in substantially isolated form comprising a sequence of nucleotides which is capable of selectively hybridizing to the genome of the human multiple sclerosis virus (HMSV) or the complement thereof, wherein HMSV is characterized by: (i) a positive stranded RNA genome; (ii) said genome comprising one or more open reading frames (ORF) encoding protein(s) or polyproteins(s); (iii) said genome encoding a reverse transcriptase enzyme; and (iv) said genome comprising nucleotide sequences which are homologous to or selectively hybridizable with any one of the nucleotide sequences illustrated in Seq. ID Nos. 1 to 6.
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公开(公告)号：EP1082545B1
公开(公告)日：2004-03-03
申请号：EP99922396.9
申请日：1999-05-24
发明人： SAKURAI, Takaki, Ebara Corporation , HARADA, Hideomi, Ebara Corporation , ASHIHARA, Kosuke, Ebara Research Co., Ltd. , ZANGENEH, Mehrdad, University College London , GOTO, Akira Ebara Research Co., Ltd.
CPC分类号： F04D29/2277 , F04D29/284
摘要： An impeller (2) with splitter blades (5) has a wide operating range without affecting the performance of the turbomachinery. The impeller (2) for a turbomachinery comprises a plurality of splitter blades (5) disposed between the full blades (4) adjacent to each other. Each of the splitter blades (5) is shaped in such a way that a spanwise distribution of a pitchwise position of a leading edge of the splitter blade is determined according to a spanwise and pitchwise non-uniformity distribution of fluid velocity of a fluid flowing into the splitter blade (5).
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公开(公告)号：EP1383863A2
公开(公告)日：2004-01-28
申请号：EP01271433.3
申请日：2001-12-19
发明人： BROWN, R. A.,Medical School,Univ. College London , BLUNN, G.,Inst. of Orthopaedics and Biomed. Eng.
IPC分类号： C12M3/00
摘要： A method for growing tissue in vitro includes the steps of:(i) providing a deformable substrate which is seeded with tissue-forming cells and which defines at least one flow channel containing a fluid culture medium;(ii) applying, substantially parallel to the flow channel, a cyclically varying load to the substrate, which load deforms the substrate to provide mechanical cueing for the cells; and(iii) inhibiting the flow of culture medium in one direction of the flow channel so that the deformation of the substrate causes a net flow of the culture medium along the flow channel in the opposing direction, thereby refreshing the culture medium in the flow channel.
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公开(公告)号：EP1341551A2
公开(公告)日：2003-09-10
申请号：EP01270348.4
申请日：2001-12-11
IPC分类号： A61K39/395 , C07K16/28 , A61P27/12 , A61L27/54 , A61L27/28
CPC分类号： A61K47/6883 , A61K47/58 , A61K47/6849
摘要： Posterior capsular opacification is inhibited by administration of polymer, having immobilised on the surface, a ligand for a death receptor, preferably joined by a spacer into the lens capsule following cataract surgery. The ligand is preferably Fas ligand. A spacer is preferably polyethylene glycol. The polymer preferably constitutes an intraocular lens.
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公开(公告)号：EP1327194A2
公开(公告)日：2003-07-16
申请号：EP01974469.7
申请日：2001-10-10
IPC分类号： G06F12/02
CPC分类号： G06F12/023
摘要： We present a Best Fit allocator for dynamic memory management. Portions of the memory that are presently unused are call free cells, and each free cell has a size. The allocator uses a bitmap which, for each number of predetermined sizes, indicates whether free memory cells of that size exist. It also employs a second data array with an entry for each of the predetermined cell sizes. When one or more free cells of a given size exist, the corresponding entry of the data array is a pointer to one of those free cells. The free cells themselves contain pointers to other free cells of the same size, or to free cells that are slightly smaller or larger. The allocator is scalable, in that the worst-case behaviour is independent of the size of the heap, and is independent of the number of free cells and of the number of cells already in use for memory storage. It is also incremental and non-disruptive, in that each memory operation (including splitting and coalescing of free cells) is guaranteed to complete within a small bounded time. We also present a novel collector and a priority queuing mechanism that operate on principles similar to those of the allocator.
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99.发明公开GLYCOSYLPHOSPHATIDYLINOSITOL SPECIFIC PHOSPHOLIPASE D PROTEINS FOR THE TREATMENT AND DIAGNOSIS OF ATHERSCLEROSIS 有权糖基化特异性磷脂酶D蛋白质用于治疗和动脉粥样硬化诊断
公开(公告)号：EP1294393A2
公开(公告)日：2003-03-26
申请号：EP01940840.0
申请日：2001-06-25
CPC分类号： C12Q1/44 , A61K38/00 , C12N9/16 , C12Y301/0405 , G01N33/564 , G01N33/573 , G01N2333/916
摘要： The present invention relates to the use of GPI-PLD for the prevention and treatment of conditions characterised by atherosclerosis. In some embodiments, this process may be caused by a failure to produce GPI-PLD, for example type 1 diabetes, or deliver GPI-PLD, such as patients deficient in apolipoprotein-A1, or those patients with autoantibodies to either GPI-PLD or Apo-A1. In other embodiments, the atherosclerotic process may result from a loss in GPI-PLD activity, e.g. where there is a genetic modification of GPI-PLD either affecting its activity or delivery to a target tissue, thereby leading to the atherosclerotic process.
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公开(公告)号：EP1228196A1
公开(公告)日：2002-08-07
申请号：EP00971584.8
申请日：2000-10-26
IPC分类号： C12N7/02
CPC分类号： C12N7/00 , C12N2750/14151
摘要： A method for purifying an adeno-associated virus, which method comprises: 1) applying a sample of impure virus to an affinity matrix under conditions to bind the adeno-associated virus to the matrix, wherein the affinity matrix comprises an affinant capable of competing with heparan sulphate for binding to the virus; 2) eluting contaminants from the matrix to produce a virus-rich matrix; 3) eluting virus from the virus-rich matrix; 4) treating the eluted virus with a protease incapable of digesting intact virus to digest any proteinaceous contaminants; and 5) separating intact virus from the digested proteinaceous contaminants.
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