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    Endogenous retrovirus and proteins encoded by env gene as a target for cancer treatment
    5.
    发明公开
    Endogenous retrovirus and proteins encoded by env gene as a target for cancer treatment 审中-公开
    Endogener逆转录病毒和ENV-Gen codierte蛋白酶目标zur Krebsbehandlung

    公开(公告)号：EP2402447A1

    公开(公告)日：2012-01-04

    申请号：EP10183796.1

    申请日：2006-03-30

    申请人： Viroxis

    发明人： Mangeney, Marianne ,  Renard, Martial ,  Heidmann, Thierry ,  Pothlichet, Julien ,  Dewannieux, Marie

    IPC分类号： C12N15/48 ,  A61K39/21 ,  C07K14/15 ,  C12N7/00

    CPC分类号： A61K38/162 ,  C07K14/005 ,  C12N7/00 ,  C12N2740/10021 ,  C12N2740/10022

    摘要： The present invention is directed to a method for the prevention and/or the treatment of cancer in a mammal, wherein the cancerous cells express at least one protein of endogenous retrovirus, particularly immunosuppressive protein such as env gene encoded protein from HERV-K, particularly the Np9 protein, said method comprising inhibiting the expression and/or the activity of said endogenous retrovirus and/or said env gene encoded immunosuppressive protein. The invention also relates to pharmaceutical compositions comprising nucleic acid capable of inhibiting said expression, ligand such as antibodies capable of inhibiting the activity of said env gene encoded protein, or immunogen or vaccinal composition capable of inducing an immune response, cellular or humoral response directed against said env gene encoded protein. The invention is further directed to the use of such env gene encoded protein, mutated or not, for the manufacture of a medicament or a vaccine composition intended for the prevention or the treatment of cancers.

    摘要翻译： 本发明涉及一种用于预防和/或治疗哺乳动物癌症的方法，其中所述癌细胞表达至少一种内源性逆转录病毒蛋白质，特别是HERV-K的免疫抑制蛋白如env基因编码的蛋白质，特别是 所述Np9蛋白，所述方法包括抑制所述内源性逆转录病毒和/或所述env基因编码的免疫抑制蛋白的表达和/或活性。 本发明还涉及包含能够抑制所述表达的核酸的药物组合物，配体如能够抑制所述env基因编码蛋白质的活性的抗体，或能诱导免疫应答的免疫原或疫苗组合物，针对 说env基因编码蛋白。 本发明进一步涉及这样的env基因编码的蛋白质的突变或不突变用于制备用于预防或治疗癌症的药物或疫苗组合物。