公开(公告)号：EP3578640A1

公开(公告)日：2019-12-11

申请号：EP18748273.2

申请日：2018-01-31

Applicant: Osaka University

Inventor： NISHIDA, Kohji ,  SEKIGUCHI, Kiyotoshi ,  HAYASHI, Ryuhei ,  SHIBATA, Shun

IPC: C12N5/0735 ,  C07K14/47 ,  C12N5/071 ,  C12N5/079 ,  C12N5/0793

Abstract: The present invention relates to a method for controlling differentiation of pluripotent stem cells, which method comprises selecting a laminin or a fragment thereof based on binding affinity for the pluripotent stem cells and inducing differentiation of the pluripotent stem cells in the presence of the laminin or a fragment thereof. Here, the binding affinity for cells can be assessed by time-course observation of the survival rate and motility of the cells. According to the present invention, a cell population containing any desired proportion of differentiated cells can be produced from pluripotent stem cells in a simple manner. The cell population obtained by this production method is very useful for cell therapy-based treatment strategies for diseases.

公开(公告)号：EP3546575A1

公开(公告)日：2019-10-02

申请号：EP17874261.5

申请日：2017-11-24

Applicant: Osaka University

Inventor： MASHIMO, Tomoji ,  MIYASAKA, Yoshiki

IPC: C12N15/09 ,  A01H5/00 ,  A01K67/027 ,  C12M1/00 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10

Abstract: A method for producing a genome edited cell or a non-human organism, comprising the step of introducing
(a) an artificial nuclease system which cleaves both ends of a genome editing target region, and
(b) a nucleic acid sequence formed by arranging a 5'-side homology arm sequence, a donor DNA sequence, and a 3'-side homology arm sequence in this order from a 5'-side, the 5'-side homology arm sequence being a homologous sequence of one nucleic acid sequence outside the genome editing target region, and the 3'-side homology arm sequence being a homologous sequence of the other nucleic acid sequence outside the genome editing target region,
into a cell or a non-human organism.

公开(公告)号：EP3536329A1

公开(公告)日：2019-09-11

申请号：EP17867818.1

申请日：2017-11-01

Applicant: Osaka University ,  GenomIdea Inc.

Inventor： KANEDA, Yasufumi ,  SAKURA, Kazuma ,  NISHIKAWA, Tomoyuki ,  FUKUSHIMA, Masanori ,  NAKAJIMA, Toshihiro

IPC: A61K35/76 ,  A61K31/7105 ,  A61K31/711 ,  A61K39/395 ,  A61K45/00 ,  A61P35/00 ,  A61P35/02 ,  A61P37/04 ,  A61P43/00

Abstract: The present invention provides an anticancer agent containing the following (1) and (2):
(1) HVJ-E (hemagglutinating virus of Japan envelope),
(2) an inhibitor of an immune checkpoint protein.

公开(公告)号：EP2821848B1

公开(公告)日：2019-09-11

申请号：EP12869723.2

申请日：2012-12-28

Applicant: Osaka University ,  Hamamatsu Photonics K.K.

Inventor： MIYANAGA, Noriaki ,  KURITA, Takashi ,  KAWASHIMA, Toshiyuki

IPC: G02F1/39 ,  H01S3/10 ,  H01S5/065

公开(公告)号：EP3153175B1

公开(公告)日：2019-08-07

申请号：EP15803250.8

申请日：2015-06-02

Applicant: Osaka University

Inventor： JONAI Nao ,  FUJINAGA Yukako ,  YUTANI Masahiro ,  SUGAWARA Yo ,  MATSUMURA Takuhiro

IPC: A61K39/00 ,  A61K39/02

公开(公告)号：EP3508446A1

公开(公告)日：2019-07-10

申请号：EP17846638.9

申请日：2017-08-31

Applicant: Osaka University ,  Fukuoka Institute Of Technology ,  Hosei University

Inventor： KUSAKABE Koichi ,  SUNNARDIANTO Gagus Ketut ,  ENOKI Toshiaki ,  MARUYAMA Isao ,  TAKAI Kazuyuki

IPC: C01B3/00 ,  C01B32/194 ,  F17C11/00

Abstract: The objective of the present invention is to provide a carbon-based hydrogen storage material having an autocatalytic capability, and a production method therefor. The present invention provides a carbon-based hydrogen storage material having an atomic defect, which is a hydrogen adsorbing-storing hydrocarbon compound having an autocatalysis reaction, wherefrom hydrogen that has been adsorbed and stored within the compound is either released while no heat is absorbed, or released while heat is generated. In addition, provided is a production method for the carbon-based hydrogen storage material having the autocatalytic capability, comprising: preparing a hydrocarbon compound serving as a production starting material for the carbon-based hydrogen storage material; setting the production starting material inside a container under a predetermined partial gas pressure; irradiating the production starting material with an ion beam and then performing annealing under predetermined conditions, thereby forming the hydrocarbon compound having the atom defect; and processing with activated hydrogen the hydrocarbon compound having the atom defect. Also provided is a production method for a hydrogen adsorption-storage device using the carbon-based hydrogen storage material.

公开(公告)号：EP3505572A1

公开(公告)日：2019-07-03

申请号：EP17843664.8

申请日：2017-08-23

Applicant: Daikin Industries, Ltd. ,  Osaka University

Inventor： HARADA, Akira ,  YAMAGUCHI, Hiroyasu ,  TAKASHIMA, Yoshinori ,  NOMIMURA, Suguru ,  ARAMOTO, Hikaru ,  IKURA, Ryohei ,  NAKAHATA, Masaki ,  IWASO, Kazuhisa ,  HIRAGA, Kentarou ,  SUGIYAMA, Akinari ,  YAMAGUCHI, Fumihiko ,  NOMURA, Takashi

IPC: C08L101/02 ,  C08F290/12 ,  C08L33/06 ,  C09D133/00 ,  C09D201/04

Abstract: An object of the present invention is to provide a macromolecular material that exhibits excellent elongation. The first macromolecular material of the present invention contains the first polymer containing the first structural unit and the second polymer containing the second structural unit. The first structural unit has a guest group in its side chain, and the second structural unit has a host group in its side chain. At least one of the first and the second polymers contains at least one fluorine group. The second macromolecular material of the present invention contains the first structural unit having a guest group in its side chain, the second structural unit having a host group in its side chain, and the third structural unit other than the first and second structural units. At least one of the first, the second, and the third structural units contains at least one fluorine group.

公开(公告)号：EP3501544A1

公开(公告)日：2019-06-26

申请号：EP17843478.3

申请日：2017-08-17

Applicant: Tokyo Institute of Technology ,  Osaka University

Inventor： NISHIYAMA, Nobuhiro ,  TAKEMOTO, Hiroyasu ,  NOMOTO, Takahiro ,  TOMODA, Keishiro ,  MATSUI, Makoto ,  YAMADA, Naoki ,  HONDA, Yuto ,  ISHII, Hideshi ,  MORI, Masaki ,  KONNO, Masamitsu

IPC: A61K47/42 ,  A61K45/00 ,  A61K47/32 ,  A61K47/34 ,  A61K47/66 ,  A61K49/00 ,  A61K49/14 ,  A61P35/00

Abstract: The present invention pertains to a ligand that contains a plurality of groups represented by formula (1) and is capable of multivalently binding to a glutamine transporter expressed in excess in a cancer cell compared to a normal cell.

公开(公告)号：EP3499201A1

公开(公告)日：2019-06-19

申请号：EP17841464.5

申请日：2017-08-10

Applicant: Osaka University

Inventor： HORISAKI Ryoichi ,  TANIDA Jun ,  EGAMI Riki

IPC: G01J9/00 ,  G01N21/17

Abstract: An electromagnetic wave phase/amplitude generation device includes a radiation unit configured to radiate electromagnetic waves of a random radiation pattern on a spatial frequency in which a state of the electromagnetic waves to be radiated for each divided region is determined to an imaging object, an imaging unit configured to generate a captured image by imaging scattered electromagnetic waves that are electromagnetic waves generated when the imaging object scatters the electromagnetic waves of the radiation pattern radiated by the radiation unit, and a generation unit configured to generate information indicating at least a phase and amplitude of the electromagnetic waves from the imaging object by performing an arithmetic sparsity constraint operation according to sparsity of the imaging object on the basis of the captured image generated by the imaging unit, information indicating the radiation pattern, and information indicating a signal of the imaging object.

公开(公告)号：EP3496713A1

公开(公告)日：2019-06-19

申请号：EP17778331.3

申请日：2017-08-12

Applicant: The Hospital for Sick Children ,  Osaka University

Inventor： PEARSON, Christopher E. ,  NAKAMORI, Masayuki ,  NAKATANI, Kazuhiko

IPC: A61K31/4375 ,  A61P25/28 ,  A61P25/18