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91.发明公开VERWENDUNG AUSGEWÄHLTER CGRP-ANTAGONISTEN IN KOMBINATION MIT ANDEREN ARZNEISTOFFEN GEGEN MIGRÄNE FÜR DIE BEHANDLUNG VON MIGRÄNE 审中-公开选定CGRP拮抗剂与其他材料免受偏头痛药物联合用于治疗偏头痛
公开(公告)号：EP1833478A1
公开(公告)日：2007-09-19
申请号：EP05823228.1
申请日：2005-12-23
发明人： RUDOLF, Klaus , DOODS, Henri , MUELLER, Stephan, Georg , ZAMPONI, Annette , STENKAMP, Dirk , LUSTENBERGER, Philipp , ARNDT, Kirsten , SCHAENZLE, Gerhard , BRICKL, Rolf-Stefan
IPC分类号： A61K31/4545 , A61P25/06
CPC分类号： A61K45/06 , A61K31/4545 , A61K31/5513 , A61K2300/00
摘要： The invention relates to a method for treating or preventing headaches, migraine, or cluster headache. Said method comprises jointly administering a therapeutically effective amount of a selected CGRP antagonist (A), a physiologically acceptable salt thereof or a hydrate of said salt, and a therapeutically effective amount of a second or third active antimigraine medical substance (B), particularly sumatriptan, zolmitriptan, or dihydroergotamine or a physiologically acceptable salt thereof. Also disclosed are the corresponding pharmaceutical compositions and the production thereof.
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92.发明公开VERWENDUNG DES HYDROCHLORIDS DER WIRKSTOFFBASE 1-[N2-[3,5-DIBROM- N-[[4-(3,4-DIHYDRO-2(1H)-(OXOCHINAZOLIN-3-YL)-1-PIPERIDINYL]-CARBONYL]-D-TYROSYL]-L-LYSYL]-4-(4-PYRIDINYL)-PIPERAZIN IN KOMBINATION MIT SUMATRIPTAN ZUR BEHANDLUNG VON MIGRÄNE 审中-公开使用活性BASE 1-¬N2¬3,5二溴-N-¬¬4-（3,4-二氢-2（1H）的盐酸 - （代喹唑啉-3-基）-1-哌啶基羰基-D- -TYROSYL -L赖氨酰-4-（4-吡啶基）哌嗪结合舒马FOR治疗偏头痛
公开(公告)号：EP1631282A1
公开(公告)日：2006-03-08
申请号：EP04723571.8
申请日：2004-03-26
发明人： DOODS, Henri , RUDOLF, Klaus , EBERLEIN, Wolfgang
IPC分类号： A61K31/4045 , A61K31/517 , A61P25/06
CPC分类号： A61K31/4045 , A61K31/517 , A61K2300/00
摘要： The invention relates to a method for the treatment or prevention of headaches, migraines or cluster headaches, said method including the combined administration of a therapeutically active quantity of the hydrochloride of the active ingredient base 1-[N2-[3,5-dibromo-N-[[4-(3,4-dihydro-2(1H)-oxoquinazolin-3-yl)-1-piperidinyl]-carbonyl]-D-tyrosyl]-L-lysyl]-4-(4-pyridinyl)-piperazine (A) and a therapeutically active quantity of the migraine active ingredient sumatriptan or a physiologically compatible salt thereof. The invention also relates to the corresponding pharmaceutical compositions and to the production of the same.
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