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1.发明公开
公开(公告)号：EP1711480A1
公开(公告)日：2006-10-18
申请号：EP05700863.3
申请日：2005-01-13
发明人： HOENKE, Christoph , RUDOLF, Klaus , BOUYSSOU, Thierry , KONETZKI, Ingo , LUSTENBERGER, Philipp , MACK, Jürgen , SCHNAPP, Andreas , WIEDENMAYER, Dieter
IPC分类号： C07D265/36 , C07D413/12 , A61K31/538 , A61P11/08
CPC分类号： C07D265/36 , C07D413/12
摘要： The invention relates to compounds of formula (1), wherein groups X, Ra, Rb, R1, R1', R2, R2', R2'', R2''', V and n can have the meanings as cited in the claims and in the description, and to the use of these compounds as medicaments, particularly for treating inflammatory and obstructive respiratory diseases.
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2.发明授权
公开(公告)号：EP1711480B1
公开(公告)日：2007-12-19
申请号：EP05700863.3
申请日：2005-01-13
发明人： HOENKE, Christoph , RUDOLF, Klaus , BOUYSSOU, Thierry , KONETZKI, Ingo , LUSTENBERGER, Philipp , MACK, Jürgen , SCHNAPP, Andreas , WIEDENMAYER, Dieter
IPC分类号： C07D265/36 , C07D413/12 , A61K31/538 , A61P11/08
CPC分类号： C07D265/36 , C07D413/12
摘要： The invention relates to compounds of formula (1), wherein groups X, Ra, Rb, R1, R1', R2, R2', R2'', R2''', V and n can have the meanings as cited in the claims and in the description, and to the use of these compounds as medicaments, particularly for treating inflammatory and obstructive respiratory diseases.
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3.发明公开VERWENDUNG AUSGEWÄHLTER CGRP-ANTAGONISTEN IN KOMBINATION MIT ANDEREN ARZNEISTOFFEN GEGEN MIGRÄNE FÜR DIE BEHANDLUNG VON MIGRÄNE 审中-公开选定CGRP拮抗剂与其他材料免受偏头痛药物联合用于治疗偏头痛
公开(公告)号：EP1833478A1
公开(公告)日：2007-09-19
申请号：EP05823228.1
申请日：2005-12-23
发明人： RUDOLF, Klaus , DOODS, Henri , MUELLER, Stephan, Georg , ZAMPONI, Annette , STENKAMP, Dirk , LUSTENBERGER, Philipp , ARNDT, Kirsten , SCHAENZLE, Gerhard , BRICKL, Rolf-Stefan
IPC分类号： A61K31/4545 , A61P25/06
CPC分类号： A61K45/06 , A61K31/4545 , A61K31/5513 , A61K2300/00
摘要： The invention relates to a method for treating or preventing headaches, migraine, or cluster headache. Said method comprises jointly administering a therapeutically effective amount of a selected CGRP antagonist (A), a physiologically acceptable salt thereof or a hydrate of said salt, and a therapeutically effective amount of a second or third active antimigraine medical substance (B), particularly sumatriptan, zolmitriptan, or dihydroergotamine or a physiologically acceptable salt thereof. Also disclosed are the corresponding pharmaceutical compositions and the production thereof.
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4.发明公开BENZODIAZEPIN-SUBSTITUIERTE PIPERDINE ZUR VERWENDUNG IN DER BEHANDLUNG VON CARDIOVASKULÄREN ERKRANKUNGEN 有权苯二氮取代哌啶用以进行血管疾病CARDIO的治疗
公开(公告)号：EP1487821A1
公开(公告)日：2004-12-22
申请号：EP03708202.1
申请日：2003-03-10
发明人： HURNAUS, Rudolf , RUDOLF, Klaus , MÜLLER, Stephan, Georg , STENKAMP, Dirk , LUSTENBERGER, Philipp , DREYER, Alexander , GERLACH, Kai , SCHINDLER, Marcus , ARNDT, Kirsten , BAUER, Eckhart
IPC分类号： C07D401/14 , C07D471/04 , A61K31/5513 , A61P3/10
CPC分类号： C07D401/14 , C07D471/04
摘要： The invention relates to substituted piperidines of general formula (I), wherein R, R2 to R5, A, X, Z and n have the meaning defined in claim 1, to their tautomers, their diastereomers, their enantiomers, their mixtures and salts, especially their physiologically acceptable salts with inorganic or organic acids or bases. Said piperidines have valuable pharmacological properties, particularly CGRP-antagonistic properties. The invention also relates to medicaments containing said compounds, to the use thereof and to a method for the production of said compounds.
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5.发明授权
公开(公告)号：EP1562603B1
公开(公告)日：2009-05-06
申请号：EP03778312.3
申请日：2003-11-11
发明人： BOUYSSOU, Thierry , BUETTNER, Frank , KONETZKI, Ingo , PESTEL, Sabine , SCHNAPP, Andreas , SCHOLLENBERGER, Hermann , SCHROMM, Kurt , HEINE, Claudia , RUDOLF, Klaus , LUSTENBERGER, Philipp , HOENKE, Christoph
IPC分类号： A61K31/538 , A61P11/00 , A61K31/535
CPC分类号： A61K31/538 , C07D265/36
摘要： The invention relates to the use of compounds of general formula (I), where the groups R1, R2 and R3 can have the meanings as given in the claims and description, for the production of a medicament for the treatment of COPD (Chronic Obstructive Pulmonary Disease) and novel compounds of general formula (I) as such.
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6.发明授权BENZODIAZEPIN-SUBSTITUIERTE PIPERDINE ZUR VERWENDUNG IN DER BEHANDLUNG VON CARDIOVASKULÄREN ERKRANKUNGEN 有权苯二氮取代哌啶用以进行血管疾病CARDIO的治疗
公开(公告)号：EP1487821B1
公开(公告)日：2007-03-21
申请号：EP03708202.1
申请日：2003-03-10
发明人： HURNAUS, Rudolf , RUDOLF, Klaus , MÜLLER, Stephan, Georg , STENKAMP, Dirk , LUSTENBERGER, Philipp , DREYER, Alexander , GERLACH, Kai , SCHINDLER, Marcus , ARNDT, Kirsten , BAUER, Eckhart
IPC分类号： C07D401/14 , C07D471/04 , A61K31/5513 , A61P3/10
CPC分类号： C07D401/14 , C07D471/04
摘要： The invention relates to substituted piperidines of general formula (I), wherein R, R2 to R5, A, X, Z and n have the meaning defined in claim 1, to their tautomers, their diastereomers, their enantiomers, their mixtures and salts, especially their physiologically acceptable salts with inorganic or organic acids or bases. Said piperidines have valuable pharmacological properties, particularly CGRP-antagonistic properties. The invention also relates to medicaments containing said compounds, to the use thereof and to a method for the production of said compounds.
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7.发明公开
公开(公告)号：EP1562603A2
公开(公告)日：2005-08-17
申请号：EP03778312.3
申请日：2003-11-11
发明人： BOUYSSOU, Thierry , BUETTNER, Frank , KONETZKI, Ingo , PESTEL, Sabine , SCHNAPP, Andreas , SCHOLLENBERGER, Hermann , SCHROMM, Kurt , HEINE, Claudia , RUDOLF, Klaus , LUSTENBERGER, Philipp , HOENKE, Christoph
IPC分类号： A61K31/538 , A61P11/00 , A61K31/535
CPC分类号： A61K31/538 , C07D265/36
摘要： The invention relates to the use of compounds of general formula (I), where the groups R1, R2 and R3 can have the meanings as given in the claims and description, for the production of a medicament for the treatment of COPD (Chronic Obstructive Pulmonary Disease) and novel compounds of general formula (I) as such.
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8.发明公开(HETERO)ARYL COMPOUNDS WITH MCH ANTAGONISTIC ACTIVITY AND MEDICAMENTS COMPRISING THESE COMPOUNDS 审中-公开（杂）与MCH拮抗作用和芳基化合物药物同这些链接
公开(公告)号：EP1943231A1
公开(公告)日：2008-07-16
申请号：EP06807530.8
申请日：2006-10-25
发明人： ROTH, Gerald Juergen , MUELLER, Stephan Georg , LEHMANN-LINTZ, Thorsten , STENKAMP, Dirk , LUSTENBERGER, Philipp , KLEY, Joerg , RUDOLF, Klaus , HECKEL, Armin , SCHINDLER, Marcus , THOMAS, Leo , LOTZ, Ralf R. H.
IPC分类号： C07D237/08 , A61K31/501 , A61P3/04
CPC分类号： C07D237/08
摘要： The present invention relates to (hetero)aryl compounds of general formula (I) wherein the groups and radicals A, B, Q, W, X, Y, Z, R1, R2, R4a, R4b, R5a, R5b, have the meanings given in claim 1. Moreover the invention relates to pharmaceutical compositions containing at least one compound according to the invention. By virtue of their MCH-receptor antagonistic activity the pharmaceutical compositions according to 10 the invention are suitable for the treatment of metabolic disorders and/or eating disorders, particularly obesity, bulimia, anorexia, hyperphagia and diabetes.
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9.发明公开2-OXO-1,2,4,5-TETRAHYDRO-1,3-BENZDIAZEPIN-3-YL-PIPERIDINE ALS CGRP-ANTAGONISTEN 有权2-氧代-1,2,4,5-四氢-1,3-苯并二氮杂-3-基 - 哌啶ALS CGRP拮抗剂
公开(公告)号：EP1863791A1
公开(公告)日：2007-12-12
申请号：EP06723571.3
申请日：2006-03-21
发明人： MUELLER, Stephan, Georg , RUDOLF, Klaus , LUSTENBERGER, Philipp , STENKAMP, Dirk , SANTAGOSTINO, Marco , PALEARI, Fabio , DREYER, Alexander , ARNDT, Kirsten , DOODS, Henri , SCHAENZLE, Gerhard
IPC分类号： C07D401/04 , C07D401/14 , A61K31/551 , A61P25/06
CPC分类号： C07D401/14 , C07D401/04
摘要： The invention relates to novel CGRP antagonists of general formula (I), in which B, R1 and R2 are defined as cited in claim 1, to their tautomers, isomers, diastereomers, enantiomers, hydrates, mixtures and salts, in addition to the hydrates of their salts, in particular their physiologically compatible salts, with inorganic or organic acids or bases. The invention also relates to medicaments containing said compounds, to their use and to a method for their production.
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公开(公告)号：EP1856070A1
公开(公告)日：2007-11-21
申请号：EP06708325.3
申请日：2006-02-16
IPC分类号： C07D265/18 , A61K31/536
CPC分类号： C07D265/18
摘要： The invention concerns the use of compounds of formula (I), wherein the radicals R1, R2 and R3 are such as defined in the description and the claims, for producing a drug for treating respiratory diseases as well as novel compounds of formula (I). The invention also concerns a method for producing said compounds, and pharmaceutical formulations containing them.
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