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816 条记录 (耗时 0.031 秒)

    INFORMATION SYSTEM DEVELOPMENT
    91.
    发明公开
    INFORMATION SYSTEM DEVELOPMENT 审中-公开
    信息系统开发中

    公开(公告)号：EP1660995A2

    公开(公告)日：2006-05-31

    申请号：EP04768169.7

    申请日：2004-08-24

    申请人： ISIS INNOVATION LIMITED

    发明人： Davies, James, Oxford University Computing Lab. ,  Crichton, Edward, Oxford University Computing Lab. ,  Soerensen, Ib Holm ,  Heilson, David

    IPC分类号： G06F9/44

    CPC分类号： G06F9/4488

    摘要： A method or apparatus for use in generating an information system, wherein an object-oriented model of the information system is provided, the model defining classes of information objects require to be supported by the information system in terms of their attributes, operations that maybe performed on the object, and an intended relationship (if any) between two or more of the objects. Built-in or predefined descriptions of the operations which maybe performed on the objects are provided in terms of conditions that should hold initially, data that might be affected, and the desired results. An operation referenced in a class definition is then automatically expanded by adding a respective built-in or predefined description thereto within the object-oriented model of the information system. It is determined if the attributes of any other class defined within the model would be affected by the operation and, if so, the operation is automatically further expanded to include an update function to update one or more attributes determined to be affected by the operation accordingly.

    SUSCEPTIBILITY GENE FOR ALZHEIMER'S DISEASE
    94.
    发明公开
    SUSCEPTIBILITY GENE FOR ALZHEIMER'S DISEASE 有权
    易感基因的阿尔茨海默病

    公开(公告)号：EP1627077A1

    公开(公告)日：2006-02-22

    申请号：EP04734298.5

    申请日：2004-05-21

    申请人： ISIS INNOVATION LIMITED

    发明人： NAGY, Zsuzsanna

    IPC分类号： C12Q1/68

    CPC分类号： C12Q1/6883 ,  C12Q2600/156

    摘要： The invention relates to genetic screens for susceptibility to Alzheimer's disease. In particular, the invention provides genetic screens based on genotyping of the p21E2c31 polymorphism and/or the p21E3+20 C/T polymorphism in the p21cip 1 gene.

    DEPLOYABLE STRUCTURE
    95.
    发明公开
    DEPLOYABLE STRUCTURE 审中-公开
    展开结构

    公开(公告)号：EP1573153A1

    公开(公告)日：2005-09-14

    申请号：EP03767985.9

    申请日：2003-12-11

    申请人： ISIS INNOVATION LIMITED

    发明人： YAN, Chen,University of Oxford ,  ZHONG, Your,University of Oxford

    IPC分类号： E04H15/50 ,  E04B1/344

    CPC分类号： E04B1/3441 ,  E04H15/50 ,  Y10T403/5766

    摘要： A deployable structure includes a structural mechanism consisting of a plurality of rigid links (1) connected together by rotational joints (2) to form an array of Bennett linkages (20). The Bennett linkages (20) are interconnected so that the structural mechanism, including all the Bennett linkages (20), has a single degree of mobility. The structural mechanism has a profile with a curvature that varies during movement to deploy the structure from a state in which its profile is flat to a state in which its profile is curved. This allows is very convenient as the structure may be assembled, stored and/or transported in the flat state, prior to deployment into the curved state. As such the structure has many application including the frame for a tent.

    PROTEIN LATTICE
    97.
    发明公开
    PROTEIN LATTICE 有权
    蛋白基质

    公开(公告)号：EP1551862A1

    公开(公告)日：2005-07-13

    申请号：EP03753741.2

    申请日：2003-10-08

    申请人： ISIS INNOVATION LIMITED

    发明人： SINCLAIR, John CharlesLab. of Molecular Biophys. ,  NOBLE, Martin Edward M.Lab. of Molecul. Biophys.

    IPC分类号： C07K1/00 ,  C12N9/18 ,  C07K14/11

    CPC分类号： C07K19/00 ,  C07K14/001 ,  C07K14/24 ,  C07K14/47 ,  C07K2319/00

    摘要： Protein lattice (1) having a regular structure with a repeating unit repeating in three dimensions may have many uses, for example to support an array of macromolecular entities for x-ray crystallography. The repeating unit comprises protein protomers (2) which each comprise at least two monomers (5, 6) fused together. The monomers (5, 6) are each monomers of a respective oligomer assembly (3, 4) into which the monomers are assembled for assembly of the protomers into the lattice. The first oligomer assembly (3) has a set of rotational symmetry axes extending in three dimensions. In said protomers (2), further monomers (6) fused to said first monomers (5) are monomers of respective further oligomer assemblies (4) which have a rotational symmetry axis of the same order as a respective one of said set of rotational symmetry axes of said first oligomer assembly (3). Thus, the repeating unit includes protomers (2) with the first monomers (5) of the protomers (2) being assembled into said first oligomer assembly (3) and, in respect of respective ones of said set of rotational symmetry axes, with further monomers (6) of the protomers (2) fused to respective first monomers (3) being assembled into respective further oligomer assemblies (4). As a result of the symmetry of the oligomer assemblies (3, 4) said rotational symmetry axis of said respective further oligomer assemblies (4) is aligned with the respective rotational symmetry axis of said first oligomer assembly (3). Thus, an N-fold fusion between the oligomer assemblies (3, 4) is produced and the rotational symmetry axes of the oligomer assemblies (3, 4) define the symmetry of the lattice.