公开(公告)号：EP3200878A1

公开(公告)日：2017-08-09

申请号：EP15847978.2

申请日：2015-10-05

申请人： Los Alamos National Security, LLC ,  Oregon Health & Science University ,  Vir Biotechnology, Inc.

发明人： BRUENING, Eric ,  FRUEH, Klaus ,  PICKER, Louis ,  KORBER, Bette T.M. ,  THEILER, James ,  MARSHALL, Emily

IPC分类号： A61P31/18 ,  A61K39/21

CPC分类号： A61K39/12 ,  A61K39/21 ,  A61K2039/53 ,  A61K2039/70 ,  C12N2710/16143 ,  C12N2740/16034 ,  C12N2740/16234

摘要： Provided herein are HIV-1 vaccines comprising a carrier and a population episensus antigen determined using the EpiGraph approach. Also provided are HIV-1 vaccines comprising a carrier, a population episensus antigen, and a tailored antigen. Also provided are methods of designing and producing an HIV-1 vaccine for a subject comprising designing vaccine antigens to optimally cover the diversity within a geographic area using an antigen amino acid sequence generated using the EpiGraph approach, and producing said designed vaccine antigen. Also provided are methods of inducing an effector memory T cell response comprising designing the one or more EpiGraph amino acid sequences, producing a vaccine comprising the one or more EpiGraph amino acid sequences and a vector, and administering the vaccine to a subject. Further provided are methods of treating HIV-1 in a subject comprising administering an effective amount of the described HIV-1 vaccines to the subject in need thereof.

摘要翻译： 本文提供了使用EpiGraph方法确定的包含载体和群体遗传抗原的HIV-1疫苗。 还提供了包含载体，群体发生抗原和定制抗原的HIV-1疫苗。 还提供了设计和生产用于受试者的HIV-1疫苗的方法，包括使用EpiGraph方法产生的抗原氨基酸序列设计疫苗抗原以最优地覆盖地理区域内的多样性，并产生所述设计的疫苗抗原。 还提供了诱导效应记忆T细胞应答的方法，包括设计一个或多个EpiGraph氨基酸序列，产生包含一个或多个EpiGraph氨基酸序列的疫苗和载体，并将该疫苗给予受试者。 进一步提供了治疗受试者中的HIV-1的方法，其包括将有效量的所述HIV-1疫苗给予有需要的受试者。

公开(公告)号：EP2539456B1

公开(公告)日：2017-04-19

申请号：EP11748246.3

申请日：2011-02-28

申请人： Los Alamos National Security, LLC ,  University of Maine System Board of Trustees

发明人： UNKEFER, Pat J. ,  ANDERSON, Penelope S. ,  KNIGHT, Thomas J.

IPC分类号： C12N15/82 ,  A01H5/00

CPC分类号： C12N15/8261 ,  C12N9/80 ,  C12N15/8227 ,  C12N15/8262 ,  Y02A40/146

摘要： The present disclosure relates to compositions and methods for increasing the leaf-to-root ratio of the signal metabolite 2-oxoglutaramate and related proline molecules in plants by modulating levels of ω-amidase to increase nitrogen use efficiency, resulting in enhanced growth, faster growth rates, greater seed and fruit/pod yields, earlier and more productive flowering, increased tolerance to high salt conditions, and increased biomass yields.

摘要翻译： 本公开涉及通过调节ω-酰胺酶水平以增加氮利用效率来增加植物中信号代谢物2-氧戊酸氨基甲酸酯和相关脯氨酸分子的叶根比的组合物和方法，从而增加生长，更快速生长 速率，更大的种子和水果/荚果产量，更早和更有效的开花，增加对高盐条件的耐受性和增加的生物量产量。

公开(公告)号：EP3062819A2

公开(公告)日：2016-09-07

申请号：EP14859243.9

申请日：2014-11-03

申请人： The Regents of the University of California ,  Los Alamos National Security LLC

发明人： ZAKREWSKY, Michael ,  MITRAGOTRI, Samir ,  FOX, David T. ,  KOPPISCH, Andrew ,  DEL SESTO, Rico ,  LOVEJOY, Katherine

IPC分类号： A61K47/04 ,  A61K47/12 ,  A61K33/42 ,  A61K9/08 ,  A61P31/04 ,  A61P17/00

CPC分类号： A61K47/24 ,  A01N33/12 ,  A01N43/36 ,  A61K9/0014 ,  A61K31/047 ,  A61K31/545 ,  A61K31/66 ,  A61K47/12 ,  A61K47/186 ,  A01N41/06 ,  A01N37/02 ,  A01N37/04 ,  A01N37/06 ,  A01N47/28 ,  A01N49/00

摘要： IIONIC LIQUIDS FOR TRANSDERMAL DRUG DELIVERY ABSTRACT The compositions and methods described herein are topically applied to the skin with negligible or no skin irritation and can direct or prevent transport through the skin. The compositions contain neat ionic liquids, optionally in combination with a drug to be delivered. In a preferred embodiment, the compositions increase transdermal transport of the drug to be delivered. In some embodiments, the compositions disrupt bacterial biofilms. This is particularly beneficial in the treatment of antibiotic resistant skin infections. In other embodiments, the compositions direct delivery within the skin. In still other embodiments, the compositions prevent transfer of substances through the stratum corneum. The disclosed compositions and methods can be tuned and modified such that they can be used to treat or prevent a variety of different diseases and disorders.

摘要翻译： 本文描述的组合物和方法局部施用于具有可忽略或无皮肤刺激性的皮肤，并且可以引导或预防通过皮肤的运输。 组合物含有纯的离子液体，任选地与待递送的药物组合。 在优选的实施方案中，组合物增加待递送药物的透皮转运。 在一些实施方案中，组合物破坏细菌生物膜。 这对抗生素抗性皮肤感染的治疗特别有益。 在其它实施方案中，组合物在皮肤内直接递送。 在其它实施方案中，组合物防止物质通过角质层转移。 所公开的组合物和方法可以被调整和修饰，使得它们可以用于治疗或预防多种不同的疾病和病症。

公开(公告)号：EP2986628A1

公开(公告)日：2016-02-24

申请号：EP14785257.8

申请日：2014-04-15

申请人： Duke University ,  The Government of The US, as Represented by The Secretary of the Army, on behalf of Walter Reed Army Institute of Research ,  The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. ,  Los Alamos National Security, LLC

发明人： KIM, Jerome ,  ROLLAND, Morgane ,  KORBER, Bette, T. ,  HAYNES, Barton, F.

IPC分类号： C07K14/16 ,  A61K39/21 ,  A61P31/18

CPC分类号： C07K14/005 ,  A61K39/12 ,  A61K2039/70 ,  C12N7/00 ,  C12N2740/16122 ,  C12N2740/16134

摘要： The present invention relates, in general, to human immunodeficiency virus-1 (HIV - 1) particular, to a polyvalent vaccine for HIV -1 and to methods of making and using same.

公开(公告)号：EP2577357B1

公开(公告)日：2015-09-02

申请号：EP11727347.4

申请日：2011-05-06

申请人： Chevron U.S.A. Inc. ,  Los Alamos National Security LLC

发明人： VU, Cung Khac ,  SINHA, Dipen N. ,  PANTEA, Cristian ,  NIHEI, Kurt T. ,  SCHMITT, Denis P. ,  SKELT, Christopher

IPC分类号： G01V1/46

CPC分类号： G01V1/00 ,  G01V1/006 ,  G01V1/46

公开(公告)号：EP2891267A2

公开(公告)日：2015-07-08

申请号：EP13833805.8

申请日：2013-08-16

申请人： Los Alamos National Security, LLC

发明人： HUGHES, Richard, J. ,  PETERSON, Charles, G. ,  THRASHER, James, T. ,  NORDHOLT, Jane, E. ,  YARD, Jon, T. ,  NEWELL, Raymond, T. ,  SOMMA, Rolando, D.

IPC分类号： H04L9/32

CPC分类号： H04L63/08 ,  G06F21/31 ,  G06F2221/2115 ,  H04L9/0852 ,  H04L9/3226 ,  H04L9/3236 ,  H04L63/083 ,  H04L2209/38 ,  H04L2463/082

摘要： Multi-factor authentication using quantum communication ("QC") includes stages for enrollment and identification. For example, a user enrolls for multi-factor authentication that uses QC with a trusted authority. The trusted authority transmits device factor information associated with a user device (such as a hash function) and user factor information associated with the user (such as an encrypted version of a user password). The user device receives and stores the device factor information and user factor information. For multi-factor authentication that uses QC, the user device retrieves its stored device factor information and user factor information, then transmits the user factor information to the trusted authority, which also retrieves its stored device factor information. The user device and trusted authority use the device factor information and user factor information (more specifically, information such as a user password that is the basis of the user factor information) in multi-factor authentication that uses QC.

公开(公告)号：EP2419763B1

公开(公告)日：2015-05-20

申请号：EP10715633.3

申请日：2010-04-16

申请人： Chevron U.S.A. Inc. ,  Los Alamos National Security LLC

发明人： JOHNSON, Paul, A. ,  VU, Cung ,  TEN CATE, James, A. ,  GUYER, Robert ,  LE BAS, Pierre-Yves ,  NIHEI, Kurt, T. ,  SCHMITT, Denis, P. ,  SKELT, Christopher

IPC分类号： G01V1/46

CPC分类号： G01V1/44 ,  G01V1/006 ,  G01V2210/125 ,  G01V2210/127 ,  G01V2210/588

公开(公告)号：EP2802735A1

公开(公告)日：2014-11-19

申请号：EP13773074.3

申请日：2013-01-14

申请人： Los Alamos National Security LLC

发明人： MACE, Jonathan, L. ,  TAPPAN, Bryce, C.

IPC分类号： E21B43/117

CPC分类号： E21B43/263 ,  C06B25/34 ,  E21B43/1185 ,  E21B47/123 ,  F23Q21/00 ,  F42B3/02 ,  F42B3/10 ,  F42B3/113 ,  F42B3/182 ,  F42B3/24 ,  F42C15/42 ,  F42D1/02 ,  F42D1/042 ,  F42D1/045 ,  F42D1/05 ,  F42D1/055 ,  F42D3/00 ,  F42D3/04 ,  F42D3/06 ,  F42D5/00 ,  Y10T29/49826

摘要： Detonation control modules and detonation control circuits are provided herein. A trigger input signal can cause a detonation control module to trigger a detonator. A detonation control module can include a timing circuit, a light-producing diode such as a laser diode, an optically triggered diode, and a high-voltage capacitor. The trigger input signal can activate the timing circuit. The timing circuit can control activation of the light-producing diode. Activation of the light-producing diode illuminates and activates the optically triggered diode. The optically triggered diode can be coupled between the high-voltage capacitor and the detonator. Activation of the optically triggered diode causes a power pulse to be released from the high-voltage capacitor that triggers the detonator.

公开(公告)号：EP2766298A2

公开(公告)日：2014-08-20

申请号：EP12837385.9

申请日：2012-09-27

申请人： Los Alamos National Security, LLC ,  The Procter & Gamble Company

发明人： ORLER, E., Bruce ,  SUTTON, Richard Matthew Charles ,  SONG, Shuangqi ,  LAMARTINE, Bruce Carvell

IPC分类号： B82B3/00

CPC分类号： A45D1/06 ,  A45D1/12 ,  A61K8/18 ,  A61K8/8129 ,  A61K8/8152 ,  A61K8/85 ,  A61K8/87 ,  A61K2800/437 ,  A61K2800/80 ,  A61K2800/805 ,  A61Q5/065

摘要： Hair was coated with polymer-containing fluid and then hot pressed to form a composite of hair and a polymer film imprinted with a nanopattem. Polychromatic light incident on the nanopattem is diffracted into dispersed colored light.

公开(公告)号：EP2297595B1

公开(公告)日：2014-05-21

申请号：EP09774059.1

申请日：2009-06-19

申请人： Chevron U.S.A. Inc. ,  Los Alamos National Security, LLC

发明人： VU, Cung, Khac ,  SINHA, Dipen, N. ,  PANTEA, Cristian ,  NIHEI, Kurt ,  SCHMITT, Denis, P. ,  SKELT, Christopher

IPC分类号： G01V1/46

CPC分类号： G01V1/46