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    SYSTEMS AND METHODS FOR EXPANDING HIGH DENSITY NON-ADHERENT CELLS
    91.
    发明公开
    SYSTEMS AND METHODS FOR EXPANDING HIGH DENSITY NON-ADHERENT CELLS 有权
    系统和膨胀高POET，概不负责细胞的方法

    公开(公告)号：EP2710118A2

    公开(公告)日：2014-03-26

    申请号：EP12724029.9

    申请日：2012-05-16

    申请人： Terumo BCT, Inc.

    发明人： ANTWILER, Glen Delbert

    IPC分类号： C12N5/00

    CPC分类号： C12M29/18 ,  C12M23/02 ,  C12M23/58 ,  C12M25/12 ,  C12M29/16

    摘要： Embodiments described herein generally relate to systems and methods for promoting the expansion of high density non-adherent cells through the use of a cell growth chamber, a mass transfer device, and a fluid circulation loop. Improved cell growth is achieved in the cell growth chamber by using a chamber having a particular orientation and shape, e.g., conical, to create a media-rich reservoir for growing cells. By placing the chamber in a vertical position, the force of media flow along the chamber walls is substantially equal and opposite to the gravitational force on the cells. The interaction of these forces maintains the non-adherent cells in suspension. The use of the cell growth chamber in conjunction with the mass transfer device and fluid circulation loop(s) creates efficiencies by relying on the cumulative and combined features of the devices.

    CUSTOMIZABLE METHODS AND SYSTEMS OF GROWING AND HARVESTING CELLS IN A HOLLOW FIBER BIOREACTOR SYSTEM
    93.
    发明公开
    CUSTOMIZABLE METHODS AND SYSTEMS OF GROWING AND HARVESTING CELLS IN A HOLLOW FIBER BIOREACTOR SYSTEM 有权
    可自定义的方法和系统育种和收获细胞在中空纤维生物反应器系统

    公开(公告)号：EP2625577A2

    公开(公告)日：2013-08-14

    申请号：EP11773365.9

    申请日：2011-10-07

    申请人： Terumo BCT, Inc.

    发明人： STANTON, Edward, Allan, IV ,  ANTWILER, Glen, Delbert ,  HOWLEY, Patrick, J. ,  KINZIE, Michael, E. ,  DODD, Jon, A. ,  MEDINA, Casey V.

    IPC分类号： G05B19/042 ,  C12M3/06

    CPC分类号： C12M41/44 ,  C12M23/42 ,  C12M23/44 ,  C12M25/10 ,  C12M25/12 ,  C12M29/16 ,  C12M29/20 ,  C12M41/48 ,  G06F8/38

    摘要： Embodiments described herein generally relate to methods and systems for configuring settings of a cell expansion system including a bioreactor. Through a user interface, a user may configure display settings, system settings, and settings associated with protocols for loading, growing and/or harvesting cells. In configuring settings for protocols and associated processes, a diagram view or window of the cell expansion system is displayed in embodiments. The diagram view displays the process settings as graphical user interface elements. Settings available for configuration are enabled for selection in the diagram view. The diagram view allows the user to visualize the settings available for task configuration and to configure enabled settings. Configured settings are stored and capable of retrieval for subsequent execution or modification of the applicable protocol.

    摘要翻译： 在基因反弹描述的实施例涉及方法和用于定制协议用于与细胞扩增系统中使用的系统，通过用户接口，用户可以创建一个定制任务用于装载，生长和/或收获细胞。 自定义任务可以包含一个或多个步骤，其中用户可以添加或省略步骤，如期望的那样。 数据可被输入用于与自定义任务，其中的实施例提供用于搜索数据相关联的设置进行自定义任务每次输入。 在另一个实施方式为自定义任务的设置可以在其中搜索设置进行配置可以存储并在自定义任务的选择而检索。 一个自定义的任务的定制和配置可能会发生使用细胞扩增系统中，在该方法中设置与图形用户界面元素相关联的图视图。

    METHODS AND SYSTEMS OF GROWING AND HARVESTING CELLS IN A HOLLOW FIBER BIOREACTOR SYSTEM WITH CONTROL CONDITIONS
    94.
    发明公开
    METHODS AND SYSTEMS OF GROWING AND HARVESTING CELLS IN A HOLLOW FIBER BIOREACTOR SYSTEM WITH CONTROL CONDITIONS 审中-公开
    方法和系统育种和收获小区在控制条件下的中空纤维生物反应器系统

    公开(公告)号：EP2625264A2

    公开(公告)日：2013-08-14

    申请号：EP11773366.7

    申请日：2011-10-07

    申请人： Terumo BCT, Inc.

    发明人： DILORENZO, Thomas G. ,  STANTON, Edward Allan IV ,  ANTWILER, Glen Delbert ,  KINZIE, Michael E. ,  NANKERVIS, Brian J. ,  GIVENS, Monique ,  MEDINA, Casey V. ,  DODD, Jon A.

    IPC分类号： C12M3/06

    CPC分类号： C12M41/44 ,  C12M23/42 ,  C12M23/44 ,  C12M25/10 ,  C12M25/12 ,  C12M29/16 ,  C12M29/20 ,  C12M41/48 ,  G06F8/38

    摘要： Embodiments described herein generally relate to methods and systems for configuring settings of a cell expansion system including a bioreactor. Through a user interface, a user may configure display settings, system settings, and settings associated with protocols for loading, growing and/or harvesting cells. In configuring settings for protocols and associated processes, a diagram view or window of the cell expansion system is displayed in embodiments. The diagram view displays the process settings as graphical user interface elements. Settings available for configuration are enabled for selection in the diagram view. The diagram view allows the user to visualize the settings available for task configuration and to configure enabled settings. Configured settings are stored and capable of retrieval for subsequent execution or modification of the applicable protocol.

    摘要翻译： 在基因反弹描述的实施例涉及方法和用于定制协议用于与细胞扩增系统中使用的系统，通过用户接口，用户可以创建一个定制任务用于装载，生长和/或收获细胞。 自定义任务可以包含一个或多个步骤，其中用户可以添加或省略步骤，如期望的那样。 数据可被输入用于与自定义任务，其中的实施例提供用于搜索数据相关联的设置进行自定义任务每次输入。 在另一个实施方式为自定义任务的设置可以在其中搜索设置进行配置可以存储并在自定义任务的选择而检索。 一个自定义的任务的定制和配置可能会发生使用细胞扩增系统中，在该方法中设置与图形用户界面元素相关联的图视图。

    SYSTEM FOR BLOOD SEPARATION WITH SIDE-TAPPED SEPARATION CHAMBER
    95.
    发明公开
    SYSTEM FOR BLOOD SEPARATION WITH SIDE-TAPPED SEPARATION CHAMBER 有权
    系统ZUR BLUTTRENNUNG MIT TRENNKAMMERN MIT SEITENGEWINDEBOHRUNG

    公开(公告)号：EP2590697A1

    公开(公告)日：2013-05-15

    申请号：EP12726288.9

    申请日：2012-05-23

    申请人： Terumo BCT, Inc.

    发明人： HOLMES, Brian M.

    IPC分类号： A61M1/36 ,  B04B5/04

    CPC分类号： A61M1/3693 ,  A61M1/30 ,  A61M1/303 ,  A61M1/308 ,  A61M1/3696 ,  B04B5/0442 ,  B04B2005/045 ,  B04B2005/0471

    摘要： A disposable blood separation set and a centrifugal blood processing system comprising a blood processing chamber adapted to be mounted on a rotor of a centrifuge; a frustro-conical cell separation chamber in fluid communication with the processing chamber, the cell separation chamber having an inlet, and outlet and a side tap outlet adjacent the inlet. The inlet may protrude into the cell separation chamber forming a circumferential well surrounding the protruding inlet. The side tap outlet may connect to the well. The set and system comprise means for selectively drawing fluid from either the outlet or the side tap outlet.

    摘要翻译： 一次性血液分离装置和离心血液处理系统，其包括适于安装在离心机的转子上的血液处理室; 与处理室流体连通的截头圆锥形细胞分离室，细胞分离室具有入口以及邻近入口的出口和侧抽头出口。 入口可以突出到细胞分离室中，形成围绕突出入口的周向井。 侧面出水口可以连接到井。 该组件和系统包括用于从出口或侧面出口出口选择性地抽取流体的装置。

    CASSETTE, WORKSTATION AND METHOD FOR MARKING CONTAINERS CONTAINING A LIQUID
    96.
    发明公开
    CASSETTE, WORKSTATION AND METHOD FOR MARKING CONTAINERS CONTAINING A LIQUID 有权
    KASSETTE，ARBEITSPLATZ UND VERFAHREN ZUM MARKIEREN VONFLÜSSIGKEITSBEHÄLTERN

    公开(公告)号：EP2585126A1

    公开(公告)日：2013-05-01

    申请号：EP11726434.1

    申请日：2011-06-21

    申请人： Terumo BCT, Inc.

    发明人： BISET, Roland ,  BIDET, François

    IPC分类号： A61M1/02 ,  A61M1/36

    CPC分类号： G06F17/00 ,  A61J2205/60 ,  A61M1/0209 ,  A61M1/0218 ,  A61M1/3696 ,  A61M2205/12 ,  A61M2205/3393 ,  A61M2205/6054

    摘要： The invention pertains to a cassette (1) provided as a cover of an accommodation section of a container (3) which can be filled with a liquid separable into individual components by means of a centrifuge, having : a plurality of containers (3, 5, 7) where a central container (3) is fixedly arranged at the cassette (1) and said central container (3) is connected to at least one outer container (5, 7) through interruptible connection means (15, 17, 11), and a data storage device (19) arranged on the cassette (1) or on the central container (3). Furthermore, the invention pertains to a workstation for marking containers (5, 7) containing a liquid and a corresponding method.

    摘要翻译： 本发明涉及一种设置在容器（3）的容纳部分的盖子上的盒子（1），该盒子可以通过离心机填充可分离成各个部件的液体，该容器（3）具有：多个容器 ，7）其中中央容器（3）固定地布置在所述盒（1）处，并且所述中央容器（3）通过可中断连接装置（15,17,11）连接到至少一个外容器（5,7） ，以及布置在盒（1）上或中央容器（3）上的数据存储装置（19）。 此外，本发明涉及一种用于标记容纳液体的容器（5,7）和相应方法的工作站。

    METHOD OF RESEEDING ADHERENT CELLS GROWN IN A HOLLOW FIBER BIOREACTOR SYSTEM
    98.
    发明公开
    METHOD OF RESEEDING ADHERENT CELLS GROWN IN A HOLLOW FIBER BIOREACTOR SYSTEM 审中-公开
    EEREM HURLFASER-BIOREAKTORSYSTEMGEZÜCHTETENADHÄRENTENZELLEN VERFAHREN ZUR NEUAUSSAAT VON

    公开(公告)号：EP2566951A1

    公开(公告)日：2013-03-13

    申请号：EP11720927.0

    申请日：2011-05-04

    申请人： Terumo BCT, Inc.

    发明人： ANTWILER, Glen, Delbert ,  WINDMILLER, David, A. ,  GIVENS, Monique

    IPC分类号： C12M3/00 ,  C12N5/0775

    摘要： This invention is directed to methods of directly reseeding harvested adherent cells grown in a hollow fiber bioreactor. Also disclosed is a novel harvest media for use in directly reseeding adherent cells into a hollow fiber bioreactor.

    摘要翻译： 本发明涉及在中空纤维生物反应器中生长的收获的贴壁细胞的直接再混合的方法。 还公开了一种新颖的收获介质，用于将贴壁细胞直接再切割成中空纤维生物反应器。