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    CONFIGURABLE METHODS AND SYSTEMS OF GROWING AND HARVESTING CELLS IN A HOLLOW FIBER BIOREACTOR SYSTEM
    1.
    发明公开
    CONFIGURABLE METHODS AND SYSTEMS OF GROWING AND HARVESTING CELLS IN A HOLLOW FIBER BIOREACTOR SYSTEM 审中-公开
    可配置方法和繁殖和收获细胞的系统，中空纤维生物反应器系统

    公开(公告)号：EP2625263A2

    公开(公告)日：2013-08-14

    申请号：EP11773364.2

    申请日：2011-10-07

    申请人： Terumo BCT, Inc.

    发明人： STANTON, Edward Allan IV ,  ANTWILER, Glen Delbert ,  HOWLEY, Patrick J. ,  KINZIE, Michael E. ,  DODD, Jon A. ,  MEDINA, Casey V.

    IPC分类号： C12M3/06 ,  G05B19/042

    摘要： Embodiments described herein generally relate to methods and systems for configuring settings of a cell expansion system including a bioreactor. Through a user interface, a user may configure display settings, system settings, and settings associated with protocols for loading, growing and/or harvesting cells. In configuring settings for protocols and associated processes, a diagram view or window of the cell expansion system is displayed in embodiments. The diagram view displays the process settings as graphical user interface elements. Settings available for configuration are enabled for selection in the diagram view. The diagram view allows the user to visualize the settings available for task configuration and to configure enabled settings. Configured settings are stored and capable of retrieval for subsequent execution or modification of the applicable protocol.

    摘要翻译： 在基因反弹描述的实施例涉及方法和用于定制协议用于与细胞扩增系统中使用的系统，通过用户接口，用户可以创建一个定制任务用于装载，生长和/或收获细胞。 自定义任务可以包含一个或多个步骤，其中用户可以添加或省略步骤，如期望的那样。 数据可被输入用于与自定义任务，其中的实施例提供用于搜索数据相关联的设置进行自定义任务每次输入。 在另一个实施方式为自定义任务的设置可以在其中搜索设置进行配置可以存储并在自定义任务的选择而检索。 一个自定义的任务的定制和配置可能会发生使用细胞扩增系统中，在该方法中设置与图形用户界面元素相关联的图视图。

    METHOD AND APPARATUS FOR CONTROLLING A CELL EXPANSION APPARATUS
    4.
    发明公开
    METHOD AND APPARATUS FOR CONTROLLING A CELL EXPANSION APPARATUS 有权
    VERFAHREN UND VORRICHTUNG ZUR STEUERUNG EINER ZELLEXPANSIONSVORRICHTUNG

    公开(公告)号：EP2566950A1

    公开(公告)日：2013-03-13

    申请号：EP11720647.4

    申请日：2011-05-02

    申请人： Terumo BCT, Inc.

    发明人： ANTWILER, Glen Delbert

    IPC分类号： C12M1/36 ,  C12M3/00

    CPC分类号： C12M41/32

    摘要： A method for controlling cell expansion comprising conducting a fluid containing cellular matter into a cellular growth area; providing oxygenated fluid to said cellular growth area to maintain conditions conducive for cell growth in said cellular growth area; monitoring inflow and outflow conditions; determining rates of change (first derivative) for selected conditions and calculating cell numbers therefrom; determining a rate of change of a rate of change (second derivative) for the selected conditions and calculating a predicted process time; and terminating the growth process when adequate cell numbers have been produced and an apparatus for performing the method.

    摘要翻译： 一种用于控制细胞扩增的方法，包括将含有细胞物质的流体导入细胞生长区域; 向所述细胞生长区域提供氧合流体以维持有助于所述细胞生长区域中的细胞生长的条件; 监测流入和流出条件; 确定所选条件的变化率（一阶导数），并从中计算细胞数; 确定所选条件的变化率（二阶导数）的变化率并计算预测的处理时间; 并且当已经产生足够的细胞编号时终止生长过程和用于执行该方法的装置。

    SYSTEMS AND METHODS FOR EXPANDING HIGH DENSITY NON-ADHERENT CELLS
    7.
    发明授权
    SYSTEMS AND METHODS FOR EXPANDING HIGH DENSITY NON-ADHERENT CELLS 有权
    用于扩展高密度非相关细胞的系统和方法

    公开(公告)号：EP2710118B1

    公开(公告)日：2018-02-07

    申请号：EP12724029.9

    申请日：2012-05-16

    申请人： Terumo BCT, Inc.

    发明人： ANTWILER, Glen Delbert

    IPC分类号： C12M1/00 ,  C12N5/00 ,  C12M1/12

    CPC分类号： C12M29/18 ,  C12M23/02 ,  C12M23/58 ,  C12M25/12 ,  C12M29/16

    摘要： Embodiments described herein generally relate to systems and methods for promoting the expansion of high density non-adherent cells through the use of a cell growth chamber, a mass transfer device, and a fluid circulation loop. Improved cell growth is achieved in the cell growth chamber by using a chamber having a particular orientation and shape, e.g., conical, to create a media-rich reservoir for growing cells. By placing the chamber in a vertical position, the force of media flow along the chamber walls is substantially equal and opposite to the gravitational force on the cells. The interaction of these forces maintains the non-adherent cells in suspension. The use of the cell growth chamber in conjunction with the mass transfer device and fluid circulation loop(s) creates efficiencies by relying on the cumulative and combined features of the devices.

    SYSTEMS AND METHODS FOR EXPANDING HIGH DENSITY NON-ADHERENT CELLS
    8.
    发明公开
    SYSTEMS AND METHODS FOR EXPANDING HIGH DENSITY NON-ADHERENT CELLS 有权
    系统和膨胀高POET，概不负责细胞的方法

    公开(公告)号：EP2710118A2

    公开(公告)日：2014-03-26

    申请号：EP12724029.9

    申请日：2012-05-16

    申请人： Terumo BCT, Inc.

    发明人： ANTWILER, Glen Delbert

    IPC分类号： C12N5/00

    CPC分类号： C12M29/18 ,  C12M23/02 ,  C12M23/58 ,  C12M25/12 ,  C12M29/16

    摘要： Embodiments described herein generally relate to systems and methods for promoting the expansion of high density non-adherent cells through the use of a cell growth chamber, a mass transfer device, and a fluid circulation loop. Improved cell growth is achieved in the cell growth chamber by using a chamber having a particular orientation and shape, e.g., conical, to create a media-rich reservoir for growing cells. By placing the chamber in a vertical position, the force of media flow along the chamber walls is substantially equal and opposite to the gravitational force on the cells. The interaction of these forces maintains the non-adherent cells in suspension. The use of the cell growth chamber in conjunction with the mass transfer device and fluid circulation loop(s) creates efficiencies by relying on the cumulative and combined features of the devices.

    METHODS AND SYSTEMS OF GROWING AND HARVESTING CELLS IN A HOLLOW FIBER BIOREACTOR SYSTEM WITH CONTROL CONDITIONS
    9.
    发明公开
    METHODS AND SYSTEMS OF GROWING AND HARVESTING CELLS IN A HOLLOW FIBER BIOREACTOR SYSTEM WITH CONTROL CONDITIONS 审中-公开
    方法和系统育种和收获小区在控制条件下的中空纤维生物反应器系统

    公开(公告)号：EP2625264A2

    公开(公告)日：2013-08-14

    申请号：EP11773366.7

    申请日：2011-10-07

    申请人： Terumo BCT, Inc.

    发明人： DILORENZO, Thomas G. ,  STANTON, Edward Allan IV ,  ANTWILER, Glen Delbert ,  KINZIE, Michael E. ,  NANKERVIS, Brian J. ,  GIVENS, Monique ,  MEDINA, Casey V. ,  DODD, Jon A.

    IPC分类号： C12M3/06

    CPC分类号： C12M41/44 ,  C12M23/42 ,  C12M23/44 ,  C12M25/10 ,  C12M25/12 ,  C12M29/16 ,  C12M29/20 ,  C12M41/48 ,  G06F8/38

    摘要： Embodiments described herein generally relate to methods and systems for configuring settings of a cell expansion system including a bioreactor. Through a user interface, a user may configure display settings, system settings, and settings associated with protocols for loading, growing and/or harvesting cells. In configuring settings for protocols and associated processes, a diagram view or window of the cell expansion system is displayed in embodiments. The diagram view displays the process settings as graphical user interface elements. Settings available for configuration are enabled for selection in the diagram view. The diagram view allows the user to visualize the settings available for task configuration and to configure enabled settings. Configured settings are stored and capable of retrieval for subsequent execution or modification of the applicable protocol.

    摘要翻译： 在基因反弹描述的实施例涉及方法和用于定制协议用于与细胞扩增系统中使用的系统，通过用户接口，用户可以创建一个定制任务用于装载，生长和/或收获细胞。 自定义任务可以包含一个或多个步骤，其中用户可以添加或省略步骤，如期望的那样。 数据可被输入用于与自定义任务，其中的实施例提供用于搜索数据相关联的设置进行自定义任务每次输入。 在另一个实施方式为自定义任务的设置可以在其中搜索设置进行配置可以存储并在自定义任务的选择而检索。 一个自定义的任务的定制和配置可能会发生使用细胞扩增系统中，在该方法中设置与图形用户界面元素相关联的图视图。