公开(公告)号：EP0804563A4

公开(公告)日：2002-06-05

申请号：EP94931356

申请日：1994-10-14

申请人： UNIV CALIFORNIA

发明人： NOONBERG SARAH H ,  HUNT ANTHONY C

IPC分类号： C12N15/11 ,  C12N15/113 ,  C12N15/85 ,  C12P19/34 ,  C12Q1/68 ,  C12N15/00 ,  C12N15/63

CPC分类号： C12Q1/6839 ,  C12N15/111 ,  C12N15/1138 ,  C12N2310/11 ,  C12N2310/111 ,  C12N2310/15 ,  C12N2320/51 ,  C12N2330/30 ,  C12P19/34 ,  C12Q1/6834 ,  C12Q2545/114 ,  C12Q2565/519 ,  C12Q2537/119 ,  C12Q2565/525

摘要： The present invention encompasses improved methods and materials for the delivering of antisense, triplex, and/or ribozyme oligonucleotides intracellularly, and RNA polymerase III-based constructs termed 'oligonucleotide generators' to accomplish the delivery of oligonucleotides. Also encompassed by the present invention are methods for screening oligonucleotide sequences that are candidates for triplex formation.

公开(公告)号：EP1100973A1

公开(公告)日：2001-05-23

申请号：EP99939046.1

申请日：1999-08-06

申请人： Guntaka, Ramareddy V.

发明人： GUNTAKA, Ramareddy, V. ,  WEBER, Karl, T. ,  KOVACS, Attilla ,  KANDALA, Jagannadhachari

IPC分类号： C12Q1/68 ,  C12N15/00 ,  C12N15/85 ,  C07H21/04

CPC分类号： C12N15/113 ,  A61K38/00 ,  C07H21/00 ,  C12N2310/15 ,  C12N2310/152

摘要： Oligomers which inhibit expression of a collagen gene are described. It is believed that each oligomer, when introduced into a cell, forms a transcription-inhibiting complex composed of the oligomer and the collagen-gene promoter region. The oligomer, preferably a phosphorothioate deoxyoligonucleotide or a ribonucleotide, preferably binds in the antiparallel orientation to the polypurine strand of a polypurine-polypyrimidine region of the promoter region of a mammalian α1(I) collagen gene.

公开(公告)号：EP0529008B1

公开(公告)日：1999-12-15

申请号：EP91920949.4

申请日：1991-04-15

申请人： ISIS PHARMACEUTICALS, INC.

发明人： ECKER, David, J.

IPC分类号： C12N15/00

CPC分类号： A61K31/70 ,  C07K14/005 ,  C12N15/1132 ,  C12N15/63 ,  C12N15/67 ,  C12N2310/15 ,  C12N2310/315 ,  C12N2740/16122 ,  C12N2740/16222 ,  C12N2740/16322

摘要： Methods for modulating the expression of genes are disclosed comprising selecting a portion RNA coded by the gene, said RNA portion having subportions forming a secondary structure, and contacting the RNA with oligonucleotide or oligonucleotide analog which can bind with at least one said subportions of the RNA. In accordance with the preferred embodiments, oligonucleotides or oligonucleotide analogs are designed to bind to RNA secondary structures which are of significance to the expression of the gene coding for said RNA. In accordance with a preferred embodiment, methods of treatment of human immunodeficiency virus are similarly disclosed wherein the oligonucleotides or oligonucleotide analogs are targeted at the TAR, CAR or gag-pol elements of HIV.

公开(公告)号：EP0904277A1

公开(公告)日：1999-03-31

申请号：EP97906591.0

申请日：1997-02-14

申请人： Millennium Pharmaceuticals, Inc.

发明人： FALB, Dean, A.

IPC分类号： A01K67 ,  A61K31 ,  A61K38 ,  A61K39 ,  A61K45 ,  A61K48 ,  A61P9 ,  C07K14 ,  C07K16 ,  C12N1 ,  C12N5 ,  C12N15

CPC分类号： C12N15/113 ,  A01K2217/05 ,  A61K38/00 ,  C07K14/47 ,  C12N2310/12 ,  C12N2310/121 ,  C12N2310/15

摘要： The present invention relates to methods and compsitions for the treatment and diagnosis of cardivascular disease, including, but not limited to, atherosclerosis, ischemia/reperfusion, hypertension, restenosis, and arterial inflammation. Specifically, the present invention identifies and describes genes which are differentially expressed in cardiovascular disease states, relative to their expression in normal, or non-cardiovascular disease states, and/or in response to manipulations relevant to cardiovascular disease. Further, the present invention identifies and describes genes via the ability of their gene products to interact with gene products involved in cardiovascular disease. Still further, the present invention provides methods for the identification and therapeutic use of compounds as treatments of cardiovascular disease. Moreover, the present invention provides methods for the diagnostic monitoring of patients undergoing clinical evaluation for the treatment of cardiovascular disease, and for monitoring the efficacy of compounds in clinical trials. Additionally, the present invention describes methods for the diagnostic evaluation and prognosis of various cardiovascular diseases, and for the identification of subjects exhibiting a predisposition to such conditions.

摘要翻译： 本发明涉及用于治疗和心血管疾病，包括诊断，但不限于，动脉粥样硬化，缺血/再灌注，高血压，再狭窄和动脉炎症的方法和组合物。 具体地，本发明识别和描述的基因其在心血管疾病状态差异过表达，相对于它们的表达在正常或非心血管疾病状态，和/或响应于相关的心血管疾病的操作。 此外，本发明鉴别和通过的它们的基因产物与心血管疾病涉及基因产物相互作用的能力描述的基因。 更进一步地，本发明提供了用于鉴定和治疗用途的化合物作为心血管疾病治疗的方法。 更过地，本发明提供了用于正在进行临床评估心血管疾病的治疗，以及用于监测临床试验化合物的功效的患者诊断监测方法。 另外，本发明描述了用于各种心血管疾病的诊断评估和预后的方法，以及用于受试者的表现出易感性检索条件的识别。

公开(公告)号：EP0894140A1

公开(公告)日：1999-02-03

申请号：EP97906817.0

申请日：1997-03-03

申请人： Provost, Fellows and Scholars of the College of the Holy and Undivided Trinity of Queen Elizabeth near Dublin

发明人： FARRAR, Gwenyth Jane ,  HUMPHRIES, Peter ,  KENNA, Paul, Francis

IPC分类号： C12N15 ,  A61K38 ,  A61K48

CPC分类号： C12N15/113 ,  A61K38/00 ,  A61K48/00 ,  C12N2310/111 ,  C12N2310/121 ,  C12N2310/15 ,  C12N2310/3181

摘要： A strategy for suppressing expression of one allele of an endogenous gene is provided comprising providing suppression effectors such as antigens nucleic acids able to bind to polymorphisms within or adjacent to a gene such that one allele of a gene is exclusively or preferentially suppressed and if required a replacement gene can be introduced. The invention has the advantage that the same suppression strategy when directed to polymorphisms could be used to suppress, in principle, many mutations in a gene. This is particularly relevant when large numbers of mutations within a single gene cause disease pathology.

公开(公告)号：EP0767668A4

公开(公告)日：1998-04-08

申请号：EP95923999

申请日：1995-06-20

申请人： UNIV CALIFORNIA

发明人： BRUICE THOMAS C ,  DEMPCY ROBERT O ,  ALMARSSON ORN

IPC分类号： A61K38/00 ,  C07H19/06 ,  C07H19/16 ,  C07H21/00 ,  C12N15/113 ,  A61K31/70 ,  C07H19/00 ,  C07H21/04

CPC分类号： C12N15/113 ,  A61K38/00 ,  C07H19/06 ,  C07H19/16 ,  C07H21/00 ,  C12N15/1132 ,  C12N2310/15 ,  C12N2310/152 ,  C12N2310/318

公开(公告)号：EP0804563A1

公开(公告)日：1997-11-05

申请号：EP94931356.0

申请日：1994-10-14

申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

发明人： NOONBERG, Sarah H. ,  HUNT, Anthony C.

IPC分类号： C12N15 ,  C12P19 ,  C12Q1

CPC分类号： C12Q1/6839 ,  C12N15/111 ,  C12N15/1138 ,  C12N2310/11 ,  C12N2310/111 ,  C12N2310/15 ,  C12N2320/51 ,  C12N2330/30 ,  C12P19/34 ,  C12Q1/6834 ,  C12Q2545/114 ,  C12Q2565/519 ,  C12Q2537/119 ,  C12Q2565/525

摘要： The present invention encompasses improved methods and materials for the delivering of antisense, triplex, and/or ribozyme oligonucleotides intracellularly, and RNA polymerase III-based constructs termed 'oligonucleotide generators' to accomplish the delivery of oligonucleotides. Also encompassed by the present invention are methods for screening oligonucleotide sequences that are candidates for triplex formation.

公开(公告)号：EP0773950A1

公开(公告)日：1997-05-21

申请号：EP95928084.0

申请日：1995-07-13

申请人： ISIS PHARMACEUTICALS, INC. ,  PERSEPTIVE BIOSYSTEMS, INC. ,  BUCHARDT, Dorte ,  EGHOLM, Michael ,  NIELSEN, Peter Eigil

发明人： EGHOLM, Michael ,  NIELSEN, Peter ,  BUCHARDT, Ole ,  DUEHOLM, Kim, L. ,  CHRISTENSEN, Leif ,  COULL, James, M. ,  KIELY, John ,  GRIFFITH, Michael

IPC分类号： C12N15 ,  A61K31 ,  A61K38 ,  A61K47 ,  A61K48 ,  A61P31 ,  A61P35 ,  A61P43 ,  C07H21 ,  C07K1 ,  C07K5 ,  C07K7 ,  C07K14 ,  C12Q1

CPC分类号： C07H21/00 ,  A61K38/00 ,  C07K5/06026 ,  C07K7/06 ,  C07K7/08 ,  C07K14/003 ,  C12N15/10 ,  C12N15/113 ,  C12N15/1132 ,  C12N15/1135 ,  C12N2310/13 ,  C12N2310/15 ,  C12N2310/3181 ,  C12N2310/3513 ,  C12Q1/68 ,  C12Q1/6813 ,  C12Q1/6869 ,  C12Q2525/107 ,  C12Q2537/119 ,  C12Q2535/107

摘要： Novel peptide nucleic acids and novel linked peptide nucleic acids, form triple stranded structures with nucleic acids. The peptide nucleic acids include ligands such as naturally occurring nucleobases attached to a peptide backbone through a suitable linker. Other nucleobases including C-pyrimidines and iso-pyrimidines can be used as the ligands in Hoogsteen strands to increase binding affinity. Two peptide nucleic acid strands are joined together with a linker to form a bis-peptide nucleic acid. The individual strands of the peptide nucleic acids in the bis compounds can be oriented either parallel or antiparallel to each other.

公开(公告)号：EP0705270A1

公开(公告)日：1996-04-10

申请号：EP94923258.0

申请日：1994-06-24

申请人： YALE UNIVERSITY

发明人： GLAZER, Peter, M. ,  HAVRE, Pamela, A. 433 Whitney Avenue

IPC分类号： C12N15 ,  A61K31 ,  A61K48 ,  A61P31 ,  A61P35 ,  C07H21 ,  C12Q1

CPC分类号： C12N15/113 ,  C07H21/00 ,  C12N15/01 ,  C12N15/102 ,  C12N2310/15 ,  C12N2310/3511 ,  C12Q1/6827

摘要： A mutagenic, triplex-forming oligonucleotide and methods for use thereof wherein the oligonucleotide is chemically modified to incorporate a mutagen and forms a triple-stranded nucleic acid molecule with a specific DNA segment of a target DNA molecule. Upon formation of the triplex, the mutagen is brought into proximity with the target molecule and causes a mutation at a specific site therein. The mutation activates, inactivates or alters the activity and function of the target molecule.

公开(公告)号：EP0684764A1

公开(公告)日：1995-12-06

申请号：EP94909689.0

申请日：1994-02-18

申请人： GENTA INCORPORATED

发明人： HARPER, Mary, Ellen ,  WOOLF, Tod, Mitchell ,  ARNOLD, Lyle, John, Jr.

IPC分类号： C12N15 ,  A61K8 ,  A61K31 ,  A61K48 ,  A61P43 ,  A61Q5 ,  A61Q7

CPC分类号： A61K31/70 ,  A61K8/606 ,  A61Q7/00 ,  C12N15/1137 ,  C12N15/1138 ,  C12N2310/15 ,  C12N2310/152 ,  C12N2310/3125 ,  C12Y103/99005

摘要： Methods of treating androgen-associated hair loss, in particular decreasing the progression of male pattern baldness using nucleoside Oligomers and Oligomers useful in the described methods are provided.