公开(公告)号：EP0773950B1

公开(公告)日：2007-08-22

申请号：EP95928084.3

申请日：1995-07-13

申请人： ISIS PHARMACEUTICALS, INC. ,  PERSEPTIVE BIOSYSTEMS, INC. ,  BUCHARDT, Dorte ,  EGHOLM, Michael ,  NIELSEN, Peter Eigil

发明人： EGHOLM, Michael ,  NIELSEN, Peter ,  BUCHARDT, Ole ,  DUEHOLM, Kim, L. ,  CHRISTENSEN, Leif ,  COULL, James, M. ,  KIELY, John ,  GRIFFITH, Michael

IPC分类号： C07H21/00 ,  C07K14/00 ,  C12N15/10

CPC分类号： C07H21/00 ,  A61K38/00 ,  C07K5/06026 ,  C07K7/06 ,  C07K7/08 ,  C07K14/003 ,  C12N15/10 ,  C12N15/113 ,  C12N15/1132 ,  C12N15/1135 ,  C12N2310/13 ,  C12N2310/15 ,  C12N2310/3181 ,  C12N2310/3513 ,  C12Q1/68 ,  C12Q1/6813 ,  C12Q1/6869 ,  C12Q2525/107 ,  C12Q2537/119 ,  C12Q2535/107

摘要： Novel peptide nucleic acids and novel linked peptide nucleic acids, form triple stranded structures with nucleic acids. The peptide nucleic acids include ligands such as naturally occurring nucleobases attached to a peptide backbone through a suitable linker. Other nucleobases including C-pyrimidines and iso-pyrimidines can be used as the ligands in Hoogsteen strands to increase binding affinity. Two peptide nucleic acid strands are joined together with a linker to form a bis-peptide nucleic acid. The individual strands of the peptide nucleic acids in the bis compounds can be oriented either parallel or antiparallel to each other.

公开(公告)号：EP0773950A1

公开(公告)日：1997-05-21

申请号：EP95928084.0

申请日：1995-07-13

申请人： ISIS PHARMACEUTICALS, INC. ,  PERSEPTIVE BIOSYSTEMS, INC. ,  BUCHARDT, Dorte ,  EGHOLM, Michael ,  NIELSEN, Peter Eigil

发明人： EGHOLM, Michael ,  NIELSEN, Peter ,  BUCHARDT, Ole ,  DUEHOLM, Kim, L. ,  CHRISTENSEN, Leif ,  COULL, James, M. ,  KIELY, John ,  GRIFFITH, Michael

IPC分类号： C12N15 ,  A61K31 ,  A61K38 ,  A61K47 ,  A61K48 ,  A61P31 ,  A61P35 ,  A61P43 ,  C07H21 ,  C07K1 ,  C07K5 ,  C07K7 ,  C07K14 ,  C12Q1

CPC分类号： C07H21/00 ,  A61K38/00 ,  C07K5/06026 ,  C07K7/06 ,  C07K7/08 ,  C07K14/003 ,  C12N15/10 ,  C12N15/113 ,  C12N15/1132 ,  C12N15/1135 ,  C12N2310/13 ,  C12N2310/15 ,  C12N2310/3181 ,  C12N2310/3513 ,  C12Q1/68 ,  C12Q1/6813 ,  C12Q1/6869 ,  C12Q2525/107 ,  C12Q2537/119 ,  C12Q2535/107

摘要： Novel peptide nucleic acids and novel linked peptide nucleic acids, form triple stranded structures with nucleic acids. The peptide nucleic acids include ligands such as naturally occurring nucleobases attached to a peptide backbone through a suitable linker. Other nucleobases including C-pyrimidines and iso-pyrimidines can be used as the ligands in Hoogsteen strands to increase binding affinity. Two peptide nucleic acid strands are joined together with a linker to form a bis-peptide nucleic acid. The individual strands of the peptide nucleic acids in the bis compounds can be oriented either parallel or antiparallel to each other.

公开(公告)号：EP0804456A1

公开(公告)日：1997-11-05

申请号：EP95938726.0

申请日：1995-10-06

申请人： ISIS PHARMACEUTICALS, INC. ,  BUCHARDT, Dorte ,  NIELSEN, Peter Eigil ,  EGHOLM, Michael

发明人： NIELSEN, Peter ,  EGHOLM, Michael ,  BUCHARDT, Ole +di ,  SONNECHSEN, Soren, Holst ,  LOHSE, Jesper ,  MANOHARAN, Muthiah ,  KIELY, John ,  GRIFFITH, Michael ,  SPRANKLE, Kelly

IPC分类号： C07D487 ,  A61K31 ,  A61K38 ,  A61K47 ,  A61K48 ,  A61P31 ,  C07H21 ,  C07K1 ,  C07K14

CPC分类号： C07K14/003

摘要： A novel class of peptide nucleic acids are described which include a conjugate attached thereto. The peptide nucleic acids generally comprise ligands such as naturally occurring DNA bases attached to a peptide backbone through a suitable linker.

公开(公告)号：EP0804456B1

公开(公告)日：2002-08-21

申请号：EP95938726.7

申请日：1995-10-06

申请人： ISIS PHARMACEUTICALS, INC. ,  BUCHARDT, Dorte ,  NIELSEN, Peter Eigil ,  EGHOLM, Michael

发明人： NIELSEN, Peter ,  EGHOLM, Michael ,  BUCHARDT, Ole +di ,  SONNECHSEN, Soren, Holst ,  LOHSE, Jesper ,  MANOHARAN, Muthiah ,  KIELY, John ,  GRIFFITH, Michael ,  SPRANKLE, Kelly

IPC分类号： C07K14/00 ,  A61K47/48

CPC分类号： C07K14/003