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    MEANS AND METHODS FOR DIAGNOSING A VIRAL INFECTION
    1.
    发明公开
    MEANS AND METHODS FOR DIAGNOSING A VIRAL INFECTION 审中-公开

    公开(公告)号：EP4443159A1

    公开(公告)日：2024-10-09

    申请号：EP23166965.6

    申请日：2023-04-06

    申请人： Bruker BioSpin GmbH & Co. KG ,  Murdoch University

    发明人： Wist, Julien ,  Sala, Samuele ,  Nitschke, Philipp ,  Nicholson, Jeremy J. ,  Holmes, Elaine ,  Trautwein, Christoph ,  Cannet, Claire

    IPC分类号： G01N33/50 ,  C07F9/6558 ,  C07F9/6561 ,  G01N33/569 ,  G01N33/68

    CPC分类号： G01N33/6848 ,  G01N33/5091 ,  G01N33/56983 ,  G01N2333/16520130101 ,  C07H19/06

    摘要： The invention relates to the field of viral diagnosis. In particular, it is directed to a method for diagnosing a viral infection or a disease associated therewith in a subject comprising the steps of: (a) determining in a sample of said subject the amount of at least one biomarker selected from the group of 3'(,5'-di)deoxy-3',4'-didehydro furanose derivatives of formula (I) with the exception of 3'-deoxy-3',4'-didehydro-cytidine (ddhC); and (b) comparing the amount(s) of the at least one biomarkers determined in (a) with a reference, thereby diagnosing a viral infection.
    Further, the invention is directed to a method for diagnosing a viral infection or a disease associated therewith in a subject comprising the steps of: (A) determining in a sample of said subject the amount of 3'-deoxy-3',4'-didehydro-cytidine (ddhC); and (B) comparing the amount of the ddhC determined in (A) with a reference, thereby diagnosing a viral infection;
    wherein the determination in (a) is done by NMR spectroscopy and the sample of the subject is a urine sample of said subject.
    The invention is also related to a diagnostic means for use in diagnosing a viral infection or a disease associated therewith, said diagnostic means comprising at least one biomarker selected from the group of 3'(,5'-di)deoxy-3',4'-didehydro furanose derivatives of formula (I) with the exception of 3'-deoxy-3',4'-didehydro-cytidine (ddhC), but also to a diagnostic means comprising 3'-deoxy-3',4'-didehydro-cytidine (ddhC) for use in diagnosing a viral infection or a disease associated therewith, wherein the amount of the biomarker is determined done by NMR spectroscopy in a urine sample of a subject.
    Furthermore, the invention is directed to a device for diagnosing a viral infection or a disease associated therewith in a sample of a subject and to a kit for identifying a subject suffering from a viral infection or a disease associated therewith.

    ANANDAMIDE-MODIFIED NUCLEIC ACID MOLECULES
    9.
    发明授权
    ANANDAMIDE-MODIFIED NUCLEIC ACID MOLECULES 有权

    公开(公告)号：EP2872180B1

    公开(公告)日：2018-08-08

    申请号：EP13735032.8

    申请日：2013-07-10

    申请人： baseclick GmbH

    发明人： CARELL, Thomas

    IPC分类号： A61K47/50

    CPC分类号： C12N15/113 ,  A61K31/713 ,  A61K47/542 ,  C07H19/04 ,  C07H19/06 ,  C07H19/16 ,  C12N2310/14 ,  C12N2310/351 ,  C12N2320/32

    摘要： The present invention refers to a conjugate comprising at least one polyunsaturated fatty acid residue, particularly an arachidonic acid residue, more particularly an anandamide (arachidonoyl ethanol amide) residue and covalently bound thereto at least one nucleosidic component selected from nucleic acids, nucleosides and nucleotides. This conjugate is suitable for the transfection of cells such as mammalian cells including human cells with high efficacy. Thus, a new delivery vehicle for therapeutic molecules including antisense molecules, siRNA molecules, miRNA molecules, antagomirs or precursors of such molecules, as well as the therapeutic nucleosides or nucleotides, is provided.