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242 条记录 (耗时 0.031 秒)

    METHOD FOR PRODUCING OLIGOSACCHARIDES AND OLIGOSACCHARIDE GLYCOSIDES BY FERMENTATION
    95.
    发明公开
    METHOD FOR PRODUCING OLIGOSACCHARIDES AND OLIGOSACCHARIDE GLYCOSIDES BY FERMENTATION 审中-公开
    通过发酵生产低聚糖和低聚糖糖苷的方法

    公开(公告)号：EP2859112A1

    公开(公告)日：2015-04-15

    申请号：EP13800288.6

    申请日：2013-06-07

    申请人： Glycom A/S

    发明人： PELTIER-PAIN, Pauline ,  DEKANY, Gyula ,  DUREAU, Remy ,  RISINGER, Christian ,  HEDEROS, Markus ,  CHAMPION, Elise

    IPC分类号： C12P19/44 ,  C07H3/06 ,  C07H5/04 ,  C07H5/08 ,  C07H15/18 ,  C12P19/28 ,  C12P19/64

    CPC分类号： C07H3/06 ,  C07H5/04 ,  C07H15/10 ,  C07H15/14 ,  C07H15/18 ,  C12P19/28 ,  C12P19/44 ,  C12P19/64 ,  Y02P20/55

    摘要： The application discloses a method for producing anomerically protected glycosidic oligosaccharide derivatives comprising the step of culturing, in a culture medium containing an anomerically protected lactose acceptor, a genetically modified cell having a recombinant gene that encodes a glycosyl transferase that can transfer a glycosyl residue of an activated sugar nucleotide to said lactose acceptor. The application further discloses a method for producing an oligosaccharide comprising the steps of: (a) culturing, in a culture medium containing an anomerically protected lactose acceptor, a genetically modified cell having a recombinant gene that encodes a glycosyl transferase that can transfer a glycosyl residue of an activated sugar nucleotide to said lactose acceptor to produce an anomerically protected glycosidic oligosaccharide derivative, then (b) removing/deprotecting the anomeric protective group.

    摘要翻译： 该申请公开了一种生产异头保护的糖苷寡糖衍生物的方法，该方法包括在含有异头保护的乳糖受体的培养基中培养具有编码糖基转移酶的重组基因的遗传修饰细胞的步骤，所述糖基转移酶可以将糖基转移酶的糖基残基 活化的糖核苷酸与所述乳糖受体结合。 本申请还公开了生产寡糖的方法，包括以下步骤：（a）在含有异头保护的乳糖受体的培养基中培养具有编码能够转移糖基残基的糖基转移酶的重组基因的遗传修饰细胞 （b）除去/脱保护端基异构保护基团，从而产生异构化保护的糖苷寡糖衍生物。

    DIVERSIFICATION OF HUMAN MILK OLIGOSACCHARIDES (HMOs) OR PRECURSORS THEREOF
    97.
    发明公开
    DIVERSIFICATION OF HUMAN MILK OLIGOSACCHARIDES (HMOs) OR PRECURSORS THEREOF 审中-公开
    人乳寡糖或其前多样化其

    公开(公告)号：EP2707380A1

    公开(公告)日：2014-03-19

    申请号：EP12785572.4

    申请日：2012-05-14

    申请人： Glycom A/S

    发明人： DEKANY, Gyula ,  CHAMPION, Elise ,  SCHROVEN, Andreas ,  HEDEROS, Markus

    IPC分类号： C07H5/04 ,  C07H1/00 ,  C07H3/06

    摘要： A method of diversification of human milk oligosaccharides (HMOs) or precursors thereof, compounds obtainable by the method, and uses and compositions involving such compounds. The method comprises a) providing at least one compound or a mixture of the compounds selected from the group consisting of: optionally sialylated and/or fucosylated lactose derivatives of general formula 2 and salts thereof; b) adding at least one enzyme comprising a transglycosidase activity to the at least one compound or a mixture of compounds provided according to step a); and c) incubating the mixture obtained according to step b).

    SYNTHESIS OF NEW FUCOSE-CONTAINING CARBOHYDRATE DERIVATIVES
    98.
    发明公开
    SYNTHESIS OF NEW FUCOSE-CONTAINING CARBOHYDRATE DERIVATIVES 审中-公开
    综合新FUCOSEHALTIGER糖衍生物的

    公开(公告)号：EP2686330A1

    公开(公告)日：2014-01-22

    申请号：EP12760395.9

    申请日：2012-03-19

    申请人： Glycom A/S

    发明人： CHAMPION, Elise ,  DEKANY, Gyula ,  HEDEROS, Markus ,  ÁGOSTON, Károly

    IPC分类号： C07H5/04 ,  C07H5/08 ,  C07H7/04 ,  C07H17/04 ,  C07H1/00

    CPC分类号： C12P19/60 ,  C07H15/08 ,  C07H15/18 ,  C07H15/203 ,  C07H17/04 ,  Y02P20/55

    摘要： A method for the synthesis of a compound of formula (1) or a salt thereof, wherein A is a carbohydrate linker which is a lactosyl moiety or which consists of a lactosyl moiety and at least one monosaccharide unit selected from the group consisting of: glucose, galactose, N-acetylglucosamine, fucose and N-acetyl neuraminic acid; and wherein R1 is one of the following anomeric protecting groups: a) -OR2, wherein R2 is a protecting group removable by catalytic hydrogenolysis; b) -SR3, wherein R3 is an optionally substituted alkyl, an optionally substituted aryl or an optionally substituted benzyl; c) -NH- C(R")=C(R')2, wherein each R' independently is one of the following electron withdrawing groups: -CN, -COOH, -COO-alkyl, -CO-alkyl, -CONH2, -CONH- alkyl or -CON(alkyl)2, or wherein the two R'-groups are linked together and form -CO-(CH2)2-4-CO- and thus form, together with the carbon atom to which they are attached, a 5-7 membered cycloalkan-1,3-dione, in which dione any of the methylene groups is optionally substituted with 1 or 2 alkyl groups, and R" is H or alkyl, in which a fucosyl donor of formula (2) wherein X is selected from the group consisting of: a guanosine diphosphatyl moiety, a lactose moiety, azide, fluoride, optionally substituted phenoxy-, optionally substituted pyridinyloxy-, optionally substituted 3-oxo-furanyloxy- of formula (A), optionally substituted 1,3,5-triazinyloxy- of formula (B), 4-methylumbelliferyloxy-group of formula (C), and a group of formula (D) wherein Ra is independently H or alkyl, or two vicinal Ra groups represent a =C(Rb)2 group, wherein Rb is independently H or alkyl, Rc is independently selected from the group consisting of alkoxy, amino, alkylamino and dialkylamino, Rd is selected from the group consisting of H, alkyl and -C(=O)Re, wherein Re is OH, alkoxy, amino, alkylamino, dialkylamino, hydrazino, alkylhydrazino, dialkylhydrazino or trialkylhydrazino, is reacted with an acceptor of formula H-A-R1 or a salt thereof, wherein A and R1 are as defined above, under the catalysis of an enzyme capable of transferring fucose. A compound of formula 1', its use in manufacture of human milk oligosaccharides, a method of manufacture of human milk oligosaccharides, and a fucosyl donor are also provided.

    Composition and methods for modulation of vascular structure and/or function
    100.
    发明公开
    Composition and methods for modulation of vascular structure and/or function 有权
    组合物和血管结构和/或功能的调制方法

    公开(公告)号：EP2468094A1

    公开(公告)日：2012-06-27

    申请号：EP11192813.1

    申请日：2002-02-08

    申请人： MARINE POLYMER TECHNOLOGIES, INC.

    发明人： The designation of the inventor has not yet been filed

    IPC分类号： A01N43/04 ,  A61K31/715 ,  A61K31/70 ,  C07H5/04 ,  C07H1/00 ,  C07H5/06 ,  C07B37/00 ,  C07B37/08

    CPC分类号： A61K31/726 ,  A61K9/0014 ,  A61K9/7007 ,  A61K31/715 ,  A61K31/722 ,  A61K31/737 ,  C08B37/0027 ,  C08B37/003 ,  Y10S514/93

    摘要： The present invention relates to compositions comprising semi-crystalline β-1-4-N-acetylglucosamine polymers (p-GlcNac) and methods utilizing such polymers modulation of vascular structure and/or function. The compositions and methods disclosed are useful for stimulating, in a p-GlcNac concentration-dependent manner, endothelin-1 release, vasoconstriction, and/or reduction in blood flow out of a breached vessel, as well as for contributing to or effecting cessation of bleeding. The methods of the present invention comprise topical administration of materials comprising semi-crystalline p-GlcNac polymers that are free of proteins, and substantially free of single amino acids as well as other organic and inorganic contaminants, and whose constituent monosaccharide sugars are attached in a β-1-4 conformation.

    摘要翻译： 本发明涉及组合物，其包括半结晶²-1-4-N-乙酰葡糖胺的聚合物（P-GlcNAc的）和方法利用血管结构和/或功能的搜索聚合物调制。 释放游离缺失的组合物和方法盘可用于刺激是有用的，在p-GlcNAc的浓度依赖的方式，内皮素-1，血管收缩，和/或减少血液中流出一个违反的容器中，以及用于促进或实现停止 出血。 本发明的方法包括包含半结晶的p GlcNAc的聚合物没材料局部给药是自由的蛋白，并且基本上不含单个氨基酸以及其它有机和无机污染物，并且其组成单糖连接在一 ²-1-4的构象。