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1.发明公开DIAGNOSIS OF MPS I DISORDERS BY MEASURING NON-REDUCING ENDS OF GAGS AFTER ENZYMATIC DIGEST 审中-公开通过测量酶促消化后非减量性标志物诊断MPS I型疾病
公开(公告)号：EP3232193A2
公开(公告)日：2017-10-18
申请号：EP17162060.2
申请日：2009-12-31
CPC分类号： C12Q1/527 , A61K31/702 , C07H3/04 , C07H3/06 , C07H5/06 , C07H7/033 , C07H11/00 , C07H13/04 , G01N33/66 , G01N2333/988 , G01N2400/40 , G01N2800/042 , G01N2800/52 , G01N2800/7071
摘要： Provided herein are processes for detecting oligosaccharides in a biological sample. In specific instances, the biological sample is provided from an individual suffering from a disorder associated with abnormal glycosaminoglycan accumulation.
摘要翻译： 本文提供了用于检测生物样品中的寡糖的方法。 在具体情况下，生物样品由患有与异常糖胺聚糖积聚相关的病症的个体提供。
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2.发明授权A METHOD FOR PREPARATION OF THE TETRASACCHARIDE LACTO-N-NEOTETRAOSE (LNNT) CONTAINING N-ACETYLLACTOSAMINE 有权VERFAHREN ZUR HERSTELLUNG VON TETRASACCHARID-LACTO-N-NEOTETRAOSE（LNNT）MIT N-ACETYLLACTOSAMIN
公开(公告)号：EP2536737B1
公开(公告)日：2017-05-31
申请号：EP11744298.8
申请日：2011-02-21
申请人： Glycom A/S
发明人： BAJZA, István , DEKANY, Gyula , ÁGOSTON, Károly , FIGUEROA PÉREZ, Ignacio , BOUTET, Julien , HEDEROS, Markus , HORVÁTH, Ferenc , KOVÁCS-PÉNZES, Piroska , KRÖGER, Lars , RÖHRIG, Christoph , SCHROVEN, Andreas , VRASIDAS, Ioannis , TRINKA, Péter , KALMÁR, László , KOVÁCS, Imre , DEMKÓ, Sándor , ÁGOSTON, Ágnes , RISINGER, Christian
IPC分类号： C07H15/18 , C07H11/00 , C07H13/04 , A61K31/702
CPC分类号： C07H3/06 , A23L5/00 , A23L7/00 , A23L29/30 , A23L33/10 , A23L33/125 , A23V2002/00 , C07H1/00 , C07H11/00 , C07H13/04 , C07H15/18 , A23V2250/28
摘要： The present invention relates to a new polymorphic form of the tetrasaccharide of formula (I) and the preperation thereof.
摘要翻译： 本发明涉及一种特别是大规模制备四糖乳-N-新四糖（LNnt，式（I））的方法，以及合成中的中间体，即LNnt的新晶型（多晶型物），以及 在药物或营养组合物中的应用。
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3.发明公开DISACCHARIDE INTERMEDIATE AND SYNTHESIS METHOD THEREOF 审中-公开DISACCHARIDZWISCHENPRODUKT UND SYNTHESEVERFAHRENDAFÜR
公开(公告)号：EP3070094A4
公开(公告)日：2017-05-10
申请号：EP14861246
申请日：2014-04-28
发明人： GUO YANGHUI , ZHOU JUNHUI , CAI QINGFENG , WEI HEGENG , BAI HUA , LONG FEI , ZHANG YUE , WU YINGQIU
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公开(公告)号：EP2376915B1
公开(公告)日：2017-03-29
申请号：EP09837207.1
申请日：2009-12-31
CPC分类号： C12Q1/527 , A61K31/702 , C07H3/04 , C07H3/06 , C07H5/06 , C07H7/033 , C07H11/00 , C07H13/04 , G01N33/66 , G01N2333/988 , G01N2400/40 , G01N2800/042 , G01N2800/52 , G01N2800/7071
摘要： Provided herein are processes for detecting oligosaccharides in a biological sample. In specific instances, the biological sample is provided from an individual suffering from a disorder associated with abnormal glycosaminoglycan accumulation.
摘要翻译： 本文提供了检测生物样品中寡糖的方法。 在具体情况下，生物样品由患有与异常糖胺聚糖累积相关的病症的个体提供。
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5.发明公开A SULPHATED POLYSACCHARIDE COMPOUND FOR THE CLINICAL USE AND THE PREPARATION AND USE THEREOF 审中-公开一种用于临床的含硫多糖化合物及其制备和用途
公开(公告)号：EP3059253A2
公开(公告)日：2016-08-24
申请号：EP15181965.3
申请日：2008-10-08
发明人： STAJIC, Vladimir , CHEETHAM, Norman , BELL, Alan
CPC分类号： C08B37/0057 , C07H11/00 , C07H13/02 , C08B37/0003
摘要： The present invention relates to a sulfated polysaccharide compound and the preparation and use thereof, and in particular to a narrow distribution low molecular weight, highly sulfated pentosan (in this instance a xylan) referred to as glucuronoxylan sulfate (GXS). The invention has been developed primarily for use in the treatment of various clinical conditions. However, it will be appreciated that the invention is not restricted this particular field of use.
摘要翻译： 本发明涉及一种硫酸化多糖化合物及其制备和用途，特别涉及称为葡糖醛酸木聚糖硫酸盐（GXS）的窄分布低分子量高度硫酸化戊聚糖（在本例中为木聚糖）。 本发明主要用于治疗各种临床症状。 然而，应该理解的是，本发明不限于这个特定的使用领域。
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6.发明公开PROCESS FOR PREPARING HEPARINOIDS AND INTERMEDIATES USEFUL IN THE SYNTHESIS THEREOF 审中-公开用于生产肝素和WHERE有用合成中间体
公开(公告)号：EP2726513A4
公开(公告)日：2015-06-10
申请号：EP12803559
申请日：2012-06-08
申请人： APICORE LLC
IPC分类号： C08B37/10 , A61K31/727
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8.发明公开SELECTIVE GLYCOSIDASE INHIBITORS AND USES THEREOF 有权SEREKTIVE GLYCOSIDASEHEMMER UND IHRE VERWENDUNG
公开(公告)号：EP2691407A4
公开(公告)日：2014-08-27
申请号：EP12765063
申请日：2012-03-20
发明人： KAUL RAMESH , MCEACHERN ERNEST J , VOCADLO DAVID J , ZHOU YUANXI , LIU KUN , SELNICK HAROLD G , WEI ZHONGYONG , MU CHANGWEI , WANG YAODE , WANG XIAONA
IPC分类号： C07H15/12 , A61K31/7056 , C07H9/06 , C07H11/00 , C07H13/00 , C07H13/12 , C07H15/18 , C07H17/07 , C07H19/04 , C12N9/24 , C12Q1/34
CPC分类号： C07H19/24 , A61K31/7056 , C07D513/04 , C07H9/06 , C07H11/00 , C07H13/12 , C07H15/04 , C07H15/12 , C07H15/18 , C07H15/203 , C07H15/207 , C07H17/02 , C07H17/04 , C12N9/99 , C12Q1/34 , C12Y302/01169
摘要： The invention provides compounds of formula (I) with substituents as specified in Claim 1 for selectively inhibiting glycosidases, prodrugs of the compounds, and pharmaceuticals compositions including the compounds or prodrugs of the compounds. The invention also provides methods of treating diseases and disorders related to over-expression of O-GlcNAcase or accumulation of O-GlcNac.
摘要翻译： 本发明提供了具有如权利要求1中所定义的取代基的式（I）化合物，其用于选择性抑制糖苷酶，化合物的前药以及包含化合物的化合物或前药的药物组合物。 本发明还提供了治疗与O-GlcNAcase的过度表达或O-GlcNac的积累有关的疾病和病症的方法。
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公开(公告)号：EP2760877A1
公开(公告)日：2014-08-06
申请号：EP12835375.2
申请日：2012-09-28
申请人： Glycom A/S
摘要： A method that can be used to make a precursor of L-fiicose from D-glucose, that comprises the steps of: a) making a compound of formula (1) from D-glucose, formula (1) wherein R
1 is acyloxy, and Q is a group (a), (b), (c) or (d), Formula (a) (b) (c) (d) or wherein R
1 is OH, and Q is a group (e), (f) or (g): Formula (e) (f) (g) wherein R
2 is acyloxy and R
3 is a sulphonyl leaving group; and b) producing 6-deoxy-L-talose from the compound of formula (1) formed in step (a), characterized in that the moiety is a highly lipophilic protecting group; compounds according to formula I, and use of a compound according to formula (1) are provided.-
10.发明公开
公开(公告)号：EP2667186A4
公开(公告)日：2014-07-16
申请号：EP12739381
申请日：2012-01-20
发明人： KANG JINGWU , ZHAN XUEQIANG
IPC分类号： G01N27/447 , A61K31/727 , C08B37/00 , C08B37/08 , C08B37/10 , G01N33/15
CPC分类号： G01N27/26 , C07H11/00 , C07H13/04 , C08B37/0075 , C08B37/0078 , G01N27/447 , G01N33/15 , G01N33/94 , G01N2333/988 , G01N2400/40 , Y10T436/143333
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