摘要:
The present invention provides pH sensitive cyanine dyes having the structure (I) wherein X and Y are independently selected from >C(C 1 - C 4 alkyl) 2 , sulfur and oxygen; R 1 and R 2 are independently selected from H, CH 2 NH 2 , SO 3 - , phosphate, phosphonate, quaternary ammonium, (CH 2 ) q COOH, NCS, CH 2 NH-COR 7 , where R 7 is C 1 - C 20 straight or branched alkyl and (CH 2 ) q COOH where q is an integer from 0 - 10; R 3 is H or -L-P where L is selected from C 1 - C 20 straight or branched alkyl optionally containing 0, 1 or 2 unsaturated groups selected from alkenyl and alkynyl, and P is selected from a reactive group, H, C 1 - C 20 straight or branched alkyl, SO 3 - , NH 2 , quaternary ammonium, CH 2 NH-COR 8 , where R 8 is C 1 - C 20 straight or branched alkyl, -(CH 2 ) m COOH, NHR 9 where R 9 is C 1 - C 20 straight or branched alkyl; n is an integer from 0 - 3; p and r are independently 0, 1, 2, 3 or 4 and where p and/or r is greater than 1, each R 1 and each R 2 may be different, and m is an integer from 1 - 10; and salts and protonated derivatives thereof and methods of using same as fluorescent reagents.
摘要:
Non-naturally occurring mutant hemoglobins rHb (bN108Q) and rHb (bL105W) are provided that have a lower oxygen affinity than that of native hemoglobin, but high cooperativity in oxygen binding. rHb (bN108Q) also exhibits enhanced stability against autoxidation. The mutant hemoglobins are preferably produced by recombinant DNA techniques. Such mutanthemoglobins may be used as a component of a blood substitute and hemoglobin therapeutics.
摘要:
A robust chelate complex is provided having formula (I) wherein M is a metal, preferably a transition metal; Z is an anionic donor atom, at least three of which are nitrogen, and the other is preferably nitrogen or oxygen; L1 is a labile ligand; Ch1, Ch2 and Ch3 are oxidation resistant chelate groups which are the same or different and which form 5- or 6-membered rings with the metal, and Ch4 is a chelate group having structure (a) wherein R1 and R2 are the same or different and are preferably selected from the group consisting of hydrogen, halogen, methyl, and CF3 or when linked, a 5- or 6-membered ring cyclo substituent. The complex provides a stable, long-lived oxidation catalyst or catalyst activator.
摘要:
The invention provides a novel bleaching composition comprising: an oxidatively stable bleach activator having structure 1 wherein Y1, Y3 and Y4 each represent a bridging group having zero, one, two or three carbon containing nodes for substitution, and Y2 is a bridging group having at least one carbon containing node for substitution, each said node containing a C(R), C(R1)(R2), or a C(R)2 unit and each R substituent is the same or different from the remaining R substituents and is selected from the group consisting of alkyl, cycloalkyl, cycloalkenyl, alkenyl, aryl, alkynyl, alkylaryl, halogen, alkoxy or phenoxy, CH2CF3, CF3 and combinations thereof, or form a substituted or unsubstituted benzene ring of which two carbon atoms in the ring form nodes in the Y unit, or together with a paired R substituent bound to the same carbon atom form a cycloalkyl or cycloalkenyl ring, which may include an atom other than carbon, e.g., cyclopentyl or cyclohexyl; M is a transition metal with oxidation states of I, II, III, IV, V or VI, or selected from Groups 6, 7, 8, 9, 10 and 11 of the Periodic Table of the Elements; Q is any counterion which would balance the charge of the compound on a stoichiometric basis; L is any labile ligand; and an effective amount of a source of an oxidizing compound.
摘要:
A method of forming a regioregular polythiophene from a polymerization reaction is described. The method proceeds by combining a soluble thiophene having at least two leaving groups with an organomagnesium reagent to form a regiochemical isomer intermediate, and adding thereto an effective amount of Ni(II) catalyst to initiate the polymerization reaction.
摘要:
A device (10) and method for monitoring a subject's eyes. The device (10) includes a light source (12) producing light of a first wavelength and producing light of a second wavelength, and the device (10) includes at least one image sensor (24, 26) positioned to receive light reflected from the subject's eyes (30). The at least one image sensor (24, 26) produces a first signal indicative of light of the first wavelength and produces a second signal indicative of light of the second wavelength. The device (10) may include a controller (28) connected to the at least one image sensor (24, 26) and receiving the first and second signals. The controller (28) may subtract the first signal from the second signal and produce a third signal indicative thereof. The controller (28) may also provide a synchronization signal to the at least one image sensor (24, 26) and may also provide the signal to other components, such as the light source (12). One or more filters (16, 18) may be provided in the path of the reflected light so as to filter the light before it reaches the at least one image sensor (24, 26). One or more lens (20, 22) may also be provided to focus the reflected light before the reflected light reaches the at least one image sensor (24, 26).
摘要:
The present invention provides for magnetic and magneto-optic recording media, transducers and data storage devices constructed therefrom that have highly oriented films having long range order in the crystal structure of the film. The recording medium includes a magnetic recording layer comprised of Co-based material, such as Co or one or more Co alloys having a (1010) crystal texture, a substrate, a first underlayer having an fcc structure and a (110) crystal texture disposed between the substrate and the magnetic recording layer. A second underlayer having a bcc structure and a (112) crystal texture is also disposed between the magnetic recording layer and the first underlayer. In particular, if a (110) Si single crystal substrate is non-oxidized certain metals having fcc structures, such as Ag, Cu, Al, and Au and fcc derivative structures, such L10 and L12 structures, can be epitaxially grown on the Si surface.
摘要:
A process for ATRP polymerization and coupling of molecules by radical processes is provided, wherein improvements are provided by selection of various ligands, counterions, transition metal compounds and/or zero oxidation state transition metals to give improved control over molecular weight, molecular weight distribution and compositions of the products formed.
摘要:
The invention provides a novel composition for bleaching cellulose based materials, such as wood pulp and paper which includes using an effective amount of a source of an oxidant and an oxidatively stable bleach activator having structure (I) wherein Y1, Y3 and Y4 each represents a bridging group having zero, one, two or three carbon containing nodes for substitution, and Y2 is a bridging group having at least one carbon containing node for substitution. Each node contains a C(R), C(R1)(R2), or a C(R)2 unit. Each R may be H, alkyl, cycloalkyl, cylcoalkenyl, alkenyl, aryl, alkynyl, alkylaryl, halogen, alkoxy, or phenoxy, CH2CF3, CF3 and combinations thereof, or form a substituted or unsubstituted benzene ring, or together with a paired R substituent bound to the same carbon atom form a cycloalkyl or cycloalkenyl ring; M is a transition metal; Q is any counterion; and L is any labile ligand.