利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

414 条记录 (耗时 0.016 秒)

    Hypouricaemic agent containing ponalrestat
    132.
    发明公开
    Hypouricaemic agent containing ponalrestat 失效
    Ponalrestat enthaltendesHyperurikämie-Mittel。

    公开(公告)号：EP0296695A2

    公开(公告)日：1988-12-28

    申请号：EP88301379.9

    申请日：1988-02-18

    申请人： ICI AMERICAS INC.

    发明人： Thyrum, Per Trygve

    IPC分类号： A61K31/50

    CPC分类号： A61K31/50

    摘要： The invention concerns a novel therapeutic agent for use in reducing raised serum uric acid levels comprising 3-(4-bromo-2-fluoro­benzyl)-4-oxo-3H-phthalazin-1-ylacetic acid or a pharmaceutically acceptable salt thereof.

    摘要翻译： 本发明涉及用于降低升高的血清尿酸水平的新型治疗剂，其包含3-（4-溴-2-氟苄基）-4-氧代-3H-酞嗪-1-基乙酸或其药学上可接受的盐。

    Deformable polyurethane having improved cure time
    133.
    发明公开
    Deformable polyurethane having improved cure time 失效
    具有改善固化时间的可变性聚氨酯

    公开(公告)号：EP0278710A3

    公开(公告)日：1988-12-07

    申请号：EP88301019

    申请日：1988-02-08

    申请人： ICI AMERICAS INC.

    发明人： Lin, Nai Wen ,  Niedt, Richard

    IPC分类号： C08G18/28 ,  C08G18/76

    CPC分类号： C08G18/6607 ,  C08G18/10 ,  C08G18/2865 ,  C08G2120/00 ,  C08G2350/00

    摘要： A system for use in making molded polyurethane objects by an open or closed casting process, said system comprising
    (A) an aromatic polyisocyanate; and (B) an active hydrogen-containing composi­tion comprising
    (i) a polyhydric alcohol having an average molecular weight in the range of about 1000 to about 8000 and an average functionality of about 2 to about 4; (ii) a polyhydric alcohol having 2 to 12 carbon atoms and an average functionality of about 2 to about 3; and (iii) a secondary monoamine of the formula
          R-NH-Rʹ
    wherein R and Rʹ are independently saturated aliphatic groups having 1 to 20 carbon atoms, provided that said secondary monoamine contains at least 4 carbon atoms.

    Aminomethylphenolic pyrazines, their preparation and use
    134.
    发明公开
    Aminomethylphenolic pyrazines, their preparation and use 失效
    氨基甲基苯并吡嗪，Verfahren zu ihrer Herstellung und ihre Verwendung。

    公开(公告)号：EP0293170A1

    公开(公告)日：1988-11-30

    申请号：EP88304696.3

    申请日：1988-05-24

    申请人： ICI AMERICAS INC.

    发明人： Schwartz, John Anthony

    IPC分类号： C07D241/28 ,  A61K31/495

    CPC分类号： C07D241/26

    摘要： The invention discloses novel pyrazine amide derivatives of the formula III (set out below) which are useful as eukalemic diuretics. Also disclosed are pharmaceutical compositions containing the novel amides and processes for the manufacture of said amides.

    摘要翻译： 本发明公开了可用作嗜碱性利尿剂的式III的新型吡嗪酰胺衍生物（如下所示）。 还公开了含有新型酰胺的药物组合物和制备所述酰胺的方法。 e

    Thiazepine compounds
    139.
    发明公开
    Thiazepine compounds 失效
    硫氮化合物

    公开(公告)号：EP0240228A1

    公开(公告)日：1987-10-07

    申请号：EP87302539.9

    申请日：1987-03-24

    申请人： ICI AMERICAS INC.

    发明人： Warawa, Edward John ,  Migler, Bernard Martin

    IPC分类号： C07D281/16 ,  A61K31/55

    CPC分类号： C07D281/16

    摘要： The compound of formula:-
    and the pharmaceutically acceptable salts thereof possess neuroleptic activity with a much reduced incidence of side effects such as acute dystonia, acute dyskinesia and tardive dyskinesia.

    摘要翻译： 下式的化合物及其药学上可接受的盐具有精神安定剂活性，副作用如急性肌张力障碍，急性运动障碍和迟发性运动障碍的发生率大大降低。

    Liquid organic polyisocyanate compositions containing urea and/or biuret structures
    140.
    发明公开
    Liquid organic polyisocyanate compositions containing urea and/or biuret structures 失效
    含有尿素和/或微生物结构的液体有机聚异氰酸酯组合物

    公开(公告)号：EP0211630A3

    公开(公告)日：1987-08-19

    申请号：EP86305934

    申请日：1986-08-01

    申请人： ICI AMERICAS INC.

    发明人： Gilis, Herbert

    IPC分类号： C08G18/10 ,  C08G18/32 ,  C08G18/76

    CPC分类号： C08G18/10 ,  C07C273/1827 ,  C08G18/5024 ,  C08G18/7818 ,  C08G2120/00

    摘要： Modified organic isocynate composition containing urea and/or biuret groups, and/or salts of these groups, prepared by reacting a blocked amine composition and a polyisocyanate composition, said blocked amine composition being the reaction product of :
    a. a primary and/or secondary organic amine composition having an average amine functionality of at least 0.1 and an average total active hydrogen functionality of from about 1.5 to about 10.0, and b. a reactivity modifying agent selected from proton acids, Lewis acids, silylating agents, metallating agents and alkylating agents, and said polyisocyanate composition comprising organic polyisocyanates and/or polyisothiocyanates having a reactive isocyanate and/or isothiocyanate functionality of at least 1.0, the reaction between said blocked amine and polyisocyanate compositions being conducted so as to provide an excess of isocyanate and/or isothiocyanate groups over total active hydrogens in the blocked amine composition of at least 1.5 : 1.0.