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    PROCESS FOR PRODUCTION OF N-CARBAMOYL-TERT-LEUCINE
    1.
    发明公开
    PROCESS FOR PRODUCTION OF N-CARBAMOYL-TERT-LEUCINE 审中-公开
    VERFAHREN ZUR HERSTELLUNG VON N-CARBAMOYL-TERT.-LEUCIN

    公开(公告)号：EP2221294A1

    公开(公告)日：2010-08-25

    申请号：EP08848907.5

    申请日：2008-11-07

    申请人： Kaneka Corporation

    发明人： KAWASAKI, Hiroaki ,  MAEHARA, Katsuji ,  MOROSHIMA, Tadashi

    IPC分类号： C07C273/18 ,  C07C275/16

    CPC分类号： C07C273/1827 ,  C07C275/16

    摘要： The present invention relates to a process for producing an N-carbamoyl-tert-leucine, characterized in mixing tert-leucine with an isocyanic acid compound while a pH of the mixture is kept at not less than 8.0 and not more than 13.5, wherein an amount of the isocyanic acid compound is not less than 0.9 times by mole and not more than 1.1 times by mole relative to an amount of the tert-leucine. According to the present invention, it becomes possible to easily produce an N-carbamoyl-tert-leucine with high efficiency, while the generation of by-products such as a dipeptide-like compound and a urea compound is prevented.

    摘要翻译： 本发明涉及一种N-氨基甲酰基 - 叔 - 亮氨酸的制造方法，其特征在于，将所述混合物的pH值保持在8.0以上且13.5以下的范围，将叔亮氨酸与异氰酸化合物混合， 异氰酸化合物的量相对于叔亮氨酸的量为0.9倍摩尔以上1.1倍以下。 根据本发明，可以高效率地容易地制备N-氨基甲酰基 - 叔 - 亮氨酸，同时可以防止二肽类化合物和尿素化合物等副产物的产生。

    1-Phenylalkyl-3-phenylurea derivatives
    7.
    发明公开
    1-Phenylalkyl-3-phenylurea derivatives 失效
    1-苯甲基-3-苯基衍生物

    公开(公告)号：EP0415123A3

    公开(公告)日：1992-04-01

    申请号：EP90114966.6

    申请日：1990-08-03

    申请人： Mitsubishi Chemical Corporation

    发明人： Sekiya, Tetsuo ,  Inoue Shinya ,  Hyodo, Chiaki ,  Okushima, Hiromi ,  Umezu, Kohei ,  Suzuki, Kazuo A 304 Mezon-Tsukushino

    IPC分类号： C07C275/28 ,  A61K31/17

    CPC分类号： C07C275/28 ,  C07C273/1827

    摘要： Novel 1-phenylalkyl-3-phenylurea derivatives represented by the following formula (I):

    wherein R¹ is an alkyl group of 1 to 8 carbon atoms, an alkoxy group of 1 to 5 carbon atoms or a halogen atom, R² is an alkyl group of 1 to 15 carbon atoms, each of R³ and R⁴ is independently an alkyl group of 1 to 5 carbon atoms, m is an integer of 1 to 3, and n is 0 or 1, are provided. The compounds are potent in reducing the cholesterol level in serum, and useful for treating hyperlipemia and atherosclerosis.

    摘要翻译： 由下式（I）表示的新型1-苯基烷基-3-苯基脲衍生物：其中R 1为1〜8个碳原子的烷基，1〜5个碳原子的烷氧基或卤素原子 R 2为1〜15个碳原子的烷基，R 3和R 4各自独立地为1〜5个碳原子的烷基，m为1〜3的整数，n为1〜 是0或1。 该化合物有效降低血清中的胆固醇水平，并且可用于治疗高脂血症和动脉粥样硬化。

    1-Phenylalkyl-3-phenylurea derivatives
    8.
    发明公开
    1-Phenylalkyl-3-phenylurea derivatives 失效
    1-苯基烷基phenylharnstoff - 衍生物。

    公开(公告)号：EP0415123A2

    公开(公告)日：1991-03-06

    申请号：EP90114966.6

    申请日：1990-08-03

    申请人： Mitsubishi Chemical Corporation

    发明人： Sekiya, Tetsuo ,  Inoue Shinya ,  Hyodo, Chiaki ,  Okushima, Hiromi ,  Umezu, Kohei ,  Suzuki, Kazuo A 304 Mezon-Tsukushino

    IPC分类号： C07C275/28 ,  A61K31/17

    CPC分类号： C07C275/28 ,  C07C273/1827

    摘要： Novel 1-phenylalkyl-3-phenylurea derivatives represented by the following formula (I):

    wherein R¹ is an alkyl group of 1 to 8 carbon atoms, an alkoxy group of 1 to 5 carbon atoms or a halogen atom, R² is an alkyl group of 1 to 15 carbon atoms, each of R³ and R⁴ is independently an alkyl group of 1 to 5 carbon atoms, m is an integer of 1 to 3, and n is 0 or 1, are provided.
    The compounds are potent in reducing the cholesterol level in serum, and useful for treating hyperlipemia and atherosclerosis.

    摘要翻译： 由下式（I）表示的新型1-苯基烷基-3-苯基脲衍生物：其中R 1为1〜8个碳原子的烷基，1〜5个碳原子的烷氧基或卤素原子 R 2为1〜15个碳原子的烷基，R 3和R 4各自独立地为1〜5个碳原子的烷基，m为1〜3的整数，n为1〜 是0或1。 该化合物有效降低血清中的胆固醇水平，并且可用于治疗高脂血症和动脉粥样硬化。