公开(公告)号：EP4387735A2

公开(公告)日：2024-06-26

申请号：EP22868219.1

申请日：2022-08-11

Applicant: SOUTHWEST RESEARCH INSTITUTE ,  The Government of The United States, as Represented by The Secretary of The Army ,  The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.

Inventor： BOHMANN, Jonathan A. ,  GUTIERREZ, Nadean M. ,  MCDONOUGH, Joseph A. ,  CAMPBELL, Robert Francis ,  JOYCE, Michael Gordon ,  PANCHAL, Rekha ,  SANKHALA, Rajeshwer ,  DUPLANTIER, Allen

IPC: A61P31/14 ,  A61K31/4184 ,  C07D235/04

CPC classification number: A61K31/445 ,  A61K31/4184

公开(公告)号：EP4293015A1

公开(公告)日：2023-12-20

申请号：EP22758865.4

申请日：2022-02-22

Applicant: Qingdao Kangqiao Pesticides and Chemicals Group Co., Ltd

Inventor： ZHANG, Laijun ,  LIU, Yu ,  LIU, Ranjin ,  CUI, Yingrui ,  WANG, Yuqi ,  WANG, Shiling ,  FENG, Ruijie ,  ZHAO, Zhanru ,  WEI, Xinhao ,  LI, Yahui ,  DU, Yaoyao ,  GONG, Chen ,  SUN, Yunxiao ,  FAN, Shien ,  GUO, Qiangqiang ,  GUO, Wei ,  GAO, Jie ,  LIU, Yingshuai ,  LI, Ning

IPC: C07D235/22 ,  C07D235/04 ,  C07D235/02 ,  C07D235/00 ,  A01N43/52 ,  A01P7/00

Abstract: Provided are a benzimidazole compound as represented by fonnula (I) or a salt thereof, a preparation method therefor, and the use thereof. The benzimidazole compound or the salt thereof has excellent insecticidal and acaricidal effects, and can display acaricidal effects especially when same is used at a low concentration.

公开(公告)号：EP4037680A1

公开(公告)日：2022-08-10

申请号：EP20871404.8

申请日：2020-10-05

Applicant: Goldfinch Bio, Inc.

Inventor： REILLY, John Francis ,  DAGON, Yossi ,  RAGHU, Hari ,  COEFFET-LE GAL, Marie-Francoise Yveline ,  DANIELS, Matthew H. ,  YU, Maolin ,  LEDEBOER, Mark W. ,  HARMANGE, Jean-Christophe P. ,  MUNDEL, Peter H.

IPC: A61K31/4164 ,  C07D235/04 ,  A61P13/12

公开(公告)号：EP4034586A1

公开(公告)日：2022-08-03

申请号：EP21822935.9

申请日：2021-03-25

Applicant: Ht Materials Corporation ,  Wang, Yifeng

Inventor： WANG, Yifeng

IPC: C08G71/02 ,  C08G16/00 ,  C08G8/02 ,  C07D235/04 ,  C08G16/06

公开(公告)号：EP3983391A1

公开(公告)日：2022-04-20

申请号：EP20821577.2

申请日：2020-06-12

Applicant: The Wistar Institute

Inventor： SCHUG, Zachary ,  SALVINO, Joseph

IPC: C07D235/04 ,  A61K31/4184

公开(公告)号：EP3865477A1

公开(公告)日：2021-08-18

申请号：EP19871674.8

申请日：2019-10-10

Applicant: Korea Research Institute of Bioscience and Biotechnology

Inventor： KWON, Oh Seok ,  KANG, Tae Joon ,  PARK, Seon Joo ,  PARK, Chul Soon ,  KIM, Kyung Ho ,  KIM, Jin Yeong ,  LEE, Ji Yeon ,  LEE, Chang Soo

IPC: C07D233/04 ,  C07D235/04 ,  G01N33/543 ,  G01N33/553

Abstract: The present invention relates to a carbene compound having substituted at the terminal polyethylene glycol (PEG) having nitrogen-containing functional groups, a carbene-metal nanoparticle complex in which the carbene compound and metal nanoparticles are bounded, a preparation method thereof, and a biosensor using same.

公开(公告)号：EP3139919B1

公开(公告)日：2020-06-03

申请号：EP15789494.0

申请日：2015-05-05

Applicant: Oncternal Therapeutics, Inc ,  University of Tennessee Research Foundation

Inventor： LU, Yan ,  DALTON, James T. ,  LI, Wei ,  MILLER, Duane D.

IPC: A61K31/4184 ,  A61K31/426 ,  A61K31/437 ,  C07D231/54 ,  C07D235/04 ,  A61K45/06 ,  C07D235/18 ,  C07D403/04 ,  C07D417/12 ,  C07D471/04 ,  C07D277/24 ,  A61P35/00

公开(公告)号：EP2991644B1

公开(公告)日：2020-03-25

申请号：EP14779540.5

申请日：2014-04-04

Applicant: University of Maryland, Baltimore

Inventor： NJAR, Vincent, C.O. ,  PURUSHOTTAMACHAR, Puranik

IPC: C07D235/04 ,  A61K31/4184 ,  C07J43/00 ,  C07D403/12 ,  C07D401/14 ,  A61K31/4164 ,  A61K31/4409 ,  A61K31/4725 ,  C07D235/08 ,  C07D401/10 ,  C07D403/10

公开(公告)号：EP3514147A1

公开(公告)日：2019-07-24

申请号：EP19161938.6

申请日：2014-04-04

Applicant: University of Maryland, Baltimore

Inventor： NJAR, Vincent, C.O. ,  PURUSHOTTAMACHAR, Puranik

IPC: C07D235/04 ,  A61K31/4184 ,  C07J43/00 ,  C07D403/12 ,  C07D401/14 ,  A61K31/4164 ,  A61K31/4409 ,  A61K31/4725 ,  C07D235/08 ,  C07D401/10 ,  C07D403/10

Abstract: Nonsteroid and steroid compounds that cause down-regulation of the androgen receptor (AR), both full length and splice variant, induce apoptosis and inhibit proliferation of inhibiting proliferation and migration of androgen sensitive cancer cells. The steroid compounds and nonsteroid compounds may be agents for the prevention and/or treatment of cancer, including prostate cancer, castration resistant prostate cancer, bladder cancer, pancreatic cancer, hepatocellular carcinoma, benign prostatic hyperplasia (BPH), Kennedy's disease, androgenetic alopecia, breast cancer, androgen-insensitive syndrome, and spinal and bulbar muscular atrophy.

公开(公告)号：EP2700946A1

公开(公告)日：2014-02-26

申请号：EP12181818.1

申请日：2012-08-24

Applicant: University of Tartu

Inventor： Uri, Asko ,  Viht, Kaido ,  Enkvist, Erki

IPC: G01N33/533 ,  C09B11/24 ,  C09B23/08 ,  C07D235/04

CPC classification number: G01N21/6486 ,  C07D403/14 ,  C07D493/10 ,  C07K7/06 ,  C09B11/24 ,  C09B23/08 ,  C12N9/12 ,  C12Q1/485

Abstract: This invention relates to fluorescent probes for screening and characterization of compounds binding to protein kinase CK2, measurement of concentration of the catalytically active form of CK2 and imaging of CK2 activity in cells and tissues. The CK2-selective probe of the present invention interacts with binding sites of both substrates of the catalytic subunit of CK2 and therefore can be used for characterization of all inhibitors binding to the active site of CK2 in the binding/displacement assay. The high affinity of the probe affords the detection of the enzyme at low concentration and characterization of inhibitors in a wide affinity range.

Abstract translation: 本发明涉及用于筛选和表征与蛋白激酶CK2结合的化合物，测量CK2催化活性形式浓度和细胞和组织中CK2活性成像的荧光探针。 本发明的CK2选择性探针与CK2的催化亚基的两个底物的结合位点相互作用，因此可用于在结合/置换测定中鉴定与CK2的活性位点结合的所有抑制剂。 探针的高亲和力提供了低浓度酶的检测和广泛亲和力范围内抑制剂的表征。