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    MEDICAL INSERTION DEVICE
    135.
    发明公开
    MEDICAL INSERTION DEVICE 审中-公开

    公开(公告)号：EP3536272A1

    公开(公告)日：2019-09-11

    申请号：EP17881065.1

    申请日：2017-12-04

    申请人： Kyungpook National University Industry-Academic Cooperation Foundation

    发明人： KIM, Kyoungtae

    IPC分类号： A61B17/88 ,  A61B17/86 ,  A61B17/70 ,  A61B5/04 ,  A61C8/00

    摘要： A medical inserting apparatus includes a screw nail which is inserted into a human body, a driver which inserts the screw nail into the human body, a current generator disposed in the driver to generate a predetermined current, a current meter disposed in the driver to measure the current, and a conductor element disposed in the screw nail and the driver along a lengthwise direction and including an exposed portion which is exposed to outside, wherein the conductor element includes a forward conductor element connected to the current generator to allow the current generated by the current generator to flow into the human body, and a reverse conductor element having one end electrically connected to the forward conductor element and the other end connected to the current generator, and including a variable resistor and the current meter installed to allow the current generated by the current generator to flow to the current meter by current division with resistance of the human body.

    DERIVATIVES OF 2-AMINO-2-(1-DODECYL-1H-1,2,3-TRIAZOL-4-YL)PROPANE-1,3-DIOL USEFUL IN THE TREATMENT OF NEURODEGENERATIVE DISEASES OR DEPRESSIONS
    138.
    发明公开
    DERIVATIVES OF 2-AMINO-2-(1-DODECYL-1H-1,2,3-TRIAZOL-4-YL)PROPANE-1,3-DIOL USEFUL IN THE TREATMENT OF NEURODEGENERATIVE DISEASES OR DEPRESSIONS 审中-公开
    用于治疗神经退行性疾病或抑郁症的2-氨基-2-（1-十二烷基-1H-1,2,3-三唑-4-基）丙烷-1,3-二醇的衍生物

    公开(公告)号：EP3301090A1

    公开(公告)日：2018-04-04

    申请号：EP17151804.6

    申请日：2017-01-17

    申请人： Kyungpook National University Industry-Academic Cooperation Foundation

    发明人： Bae, Jae-Sung ,  Jin, Hee Kyung ,  Park, Min Hee

    IPC分类号： C07D249/04 ,  A61K31/4192 ,  A61P25/24 ,  A61P25/28

    摘要： The present invention relates to a pharmaceutical composition for use in preventing or treating a neurodegenerative disease or depression comprising derivatives of 2-amino-2-(1-dodecyl-1H-1,2,3-triazol-4-yl)propane-1,3-diol as an active ingredient. In particular, the present invention relates to a pharmaceutical composition for preventing or treating a neurodegenerative disease or depression comprising as an active ingredient the above mentioned compounds which possess an effect of inhibiting ASM activity.
    In comparison with conventional ASM inhibitor agents, the novel ASM inhibitory compounds of the Chemical Formula 1 according to the present invention are excellent in therapeutic effects such as inhibiting ASM activity, reducing Aβ plaques in the brain environment of Alzheimer's disease, recovering the damages by autophagy, and ameliorating nerve inflammation. Hence, the compounds of the present invention possess the excellent industrial applicability since they can be used in the development of agents for preventing or treating a neurodegenerative disease including Alzheimer's disease. Further, considering the previous reports that the inhibition of ASM activity is effective in improving depression, the ASM inhibitory compounds of the Chemical Formula 1 according to the present invention can be used effectively as an agent for preventing or treating a neurological disorder including depression.

    摘要翻译： 本发明涉及用于预防或治疗神经退行性疾病或抑郁症的药物组合物，其包含2-氨基-2-（1-十二烷基-1H-1,2,3-三唑-4-基）丙烷-1 ，3-二醇作为活性成分。 具体而言，本发明涉及用于预防或治疗神经退行性疾病或抑郁症的药物组合物，其包含上述具有抑制ASM活性作用的化合物作为活性成分。 与常规ASM抑制剂相比，本发明化学式1的新型ASM抑制性化合物具有优异的治疗效果，例如抑制ASM活性，减少阿尔茨海默病脑环境中的Aβ斑块，通过自噬恢复损伤 并改善神经炎症。 因此，本发明的化合物具有优异的工业实用性，因为它们可用于开发用于预防或治疗包括阿尔茨海默氏病的神经退行性疾病的药剂。 此外，考虑到先前报道抑制ASM活性有效改善抑郁症，根据本发明的化学式1的ASM抑制性化合物可有效用作预防或治疗包括抑郁症的神经障碍的药剂。

    PEPTIDE FOR TARGETING AUTOPHAGIC CELLS AND USE THEREOF
    139.
    发明公开
    PEPTIDE FOR TARGETING AUTOPHAGIC CELLS AND USE THEREOF 审中-公开
    用于靶向自噬细胞的肽及其用途

    公开(公告)号：EP3263584A1

    公开(公告)日：2018-01-03

    申请号：EP16755929.3

    申请日：2016-02-26

    申请人： Kyungpook National University Industry-Academic Cooperation Foundation

    发明人： LEE, Byung-Heon ,  ACHARYA, Bodhraj

    IPC分类号： C07K7/06 ,  G01N33/53 ,  G01N33/58 ,  A61K47/50 ,  A61K49/00

    CPC分类号： C07K7/06 ,  A61K31/436 ,  A61K31/4706 ,  A61K47/50 ,  A61K47/62 ,  A61K49/00 ,  C07K2319/035 ,  G01N33/56966 ,  G01N33/58

    摘要： The present invention relates to an autophagic cell targeted peptide and its use. More particularly, the present invention relates to a polypeptide comprising an amino acid sequence represented by the general formula (I) and specifically binding to an autophagic cell and a composition for detecting autophagic cells comprising the same as an active ingredient, a drug delivery composition containing the same as an active ingredient, and a composition for imaging comprising the same as an active ingredient.
    The peptide of the present invention specifically binds to the cell membrane of autophagic cells and can be applied to various kinds of tissues and cells. Also the detection and imaging effect of autophagy is remarkable in vitro and in vivo.

    摘要翻译： 自噬细胞靶向肽及其用途技术领域本发明涉及自噬细胞靶向肽及其用途。 更具体地说，本发明涉及包含由通式（I）表示的氨基酸序列并特异性地与自噬细胞结合的多肽和包含其作为活性成分的用于检测自噬细胞的组合物，药物递送组合物，其含有 与活性成分相同的成分以及包含其作为活性成分的用于成像的组合物。 本发明的肽与自噬细胞的细胞膜特异性结合，可以应用于各种组织和细胞。 自噬的检测和成像效果在体外和体内都是显着的。