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12 条记录 (耗时 0.019 秒)

    TARGET-AIMING DRUG DELIVERY SYSTEM FOR DIAGNOSIS AND TREATMENT OF CANCER CONTAINING LIPOSOME LABELED WITH PEPTIDES WHICH SPECIFICALLY TARGETS INTERLEUKIN-4 RECEPTORS, AND MANUFACTURING METHOD THEREOF
    1.
    发明公开
    TARGET-AIMING DRUG DELIVERY SYSTEM FOR DIAGNOSIS AND TREATMENT OF CANCER CONTAINING LIPOSOME LABELED WITH PEPTIDES WHICH SPECIFICALLY TARGETS INTERLEUKIN-4 RECEPTORS, AND MANUFACTURING METHOD THEREOF 有权
    目标靶向释放系统与PEPTIDMARKIERTEM脂质体特别在拟过程白细胞介素-4受体及其生产诊断和治疗癌症的

    公开(公告)号：EP2520281A2

    公开(公告)日：2012-11-07

    申请号：EP10841275.0

    申请日：2010-12-29

    申请人： Kyungpook National University Industry- Academic Cooperation Foundation ,  Industrial Technology Research Institute

    发明人： KIM, In San ,  LEE, Byung Heon ,  LU, Maggie JM ,  LIANG, Hsiang-Fa ,  KO, Yi-Ju ,  LO, Ya-Chin ,  CHANG, Li-Wen ,  WEI, Ming-Cheng

    IPC分类号： A61K9/127 ,  A61K47/30 ,  A61K47/18 ,  A61K38/20 ,  A61P35/00

    CPC分类号： A61K31/704 ,  A61K9/1271 ,  A61K38/00 ,  A61K47/6911

    摘要： The present invention relates to a target-aiming drug delivery system for diagnosis and treatment of cancer containing liposome labeled with peptides which specifically targets interleukin-4 receptors, and a manufacturing method thereof. The liposome which contains anticancer drugs labeled with IL4RPep peptides prepared in accordance with the present invention can deliver drugs to cancer cells in which IL-4 receptors are overexpressed by IL4RPep peptides which specifically bind to IL-4 receptors, and the drug delivery can recognize cancer cells specifically by a label. Thus, IL4RPep peptides can increase the effect of drugs only on cancer tissues and at the same time significantly reduce the side effects on normal tissues, which makes possible in vivo(molecular) imaging and early diagnosis of tumors. Therefore, the liposome which contains anticancer drugs labeled with IL4Pep peptides of the present invention can be applied, as the target-aiming drug delivery system, effectively to the diagnosis and treatment of cancers.

    摘要翻译： 本发明涉及一种靶向药物递送系统，用于诊断和治疗标记与肽癌症含脂质体特异性靶向白介素-4受体，以及它们的制造方法。 其中包含标记有在雅舞蹈制备本发明可以对癌症细胞，在其中IL-4受体被IL4RPep缩氨酸肽过度表达的特异性结合IL-4受体的药物递送IL4RPep缩氨酸肽抗癌药物的脂质体，和药物递送可以识别癌 特别是通过一个标签的细胞。 因此，IL4RPep缩氨酸肽可以增加仅在癌组织和在Sametime大大减少对正常组织，在体内（分子）成像和肿瘤的早期诊断成为可能的副作用的药物的效果。 因此，其中包含与标记的本发明的肽IL4Pep抗癌药物脂质体可以应用，作为靶向药物递送系统，有效地对癌症的诊断和治疗。

    PROTEIN SKELETAL MODULE WHICH INCREASES THE BINDING AFFINITY AND BINDING SPECIFICITY OF ACTIVE POLYPEPTIDES
    5.
    发明公开
    PROTEIN SKELETAL MODULE WHICH INCREASES THE BINDING AFFINITY AND BINDING SPECIFICITY OF ACTIVE POLYPEPTIDES 有权
    蛋白骨架模块以增加亲和力和结合活性多肽的结合特异性

    公开(公告)号：EP2700649A2

    公开(公告)日：2014-02-26

    申请号：EP12773577.7

    申请日：2012-04-18

    申请人： Kyungpook National University Industry- Academic Cooperation Foundation

    发明人： CHA, Kiweon ,  SO, In-Seop ,  KIM, Soyoun ,  LEE, Byung-Heon ,  KIM, In San

    IPC分类号： C07K14/705 ,  C12N15/12 ,  G01N33/68

    CPC分类号： C07K14/485 ,  C07K14/47 ,  C07K14/5406 ,  C07K14/705 ,  C07K2319/00 ,  G01N33/68

    摘要： The present invention relates to a novel protein skeletal module which increases the binding affinity or binding specificity of active polypeptides. More particularly, the present invention relates to a protein skeletal module comprising polypeptides consisting of the 1 st to 19 th amino acids of the amino acid sequence expressed in sequence number 1; polypeptides comprising active polypeptides; and polypeptides consisting of the 29 th to 86 th amino acids of the amino acid sequence expressed in sequence ID number 1. The present invention also relates to a method for preparing the protein skeletal module. The protein skeletal module of the present invention increases the binding affinity or binding specificity of active polypeptides embedded therein, and therefore is effective in diagnosing and treating diseases.

    摘要翻译： 本发明涉及一种新的蛋白质骨架模块，这增加了结合亲和力或活性的多肽的结合特异性。 更具体地，本发明涉及一种蛋白质骨架模块包括多肽，其由第1至第19中的序列号1中过表达的氨基酸序列的氨基酸; 多肽，其包含的活性多肽; 第29届的和多肽，其由以第86次在序列ID号1中。因此，本发明涉及一种用于制备所述蛋白质骨架模块中过表达的氨基酸序列的氨基酸。 本发明的蛋白质骨架模块增大嵌入其中活性多肽的结合亲和力或结合特异性，并因此能有效地诊断和治疗疾病。

    PEPTIDES FOR TARGETING APOPTOTIC CELLS AND USES THEREOF
    6.
    发明公开
    PEPTIDES FOR TARGETING APOPTOTIC CELLS AND USES THEREOF 有权
    凋亡细胞上LOOKING肽及其用途

    公开(公告)号：EP2279201A1

    公开(公告)日：2011-02-02

    申请号：EP09746749.2

    申请日：2009-05-12

    申请人： Kyungpook National University Industry- Academic Cooperation Foundation

    发明人： LEE, Byung Heon ,  KIM, In San

    IPC分类号： C07K7/06

    CPC分类号： C07K7/06 ,  A61K38/00 ,  A61K47/64 ,  A61K49/0032 ,  A61K49/0043 ,  A61K49/0056 ,  C07K2319/33 ,  G01N2510/00

    摘要： The present invention relates to a peptide capable of specifically targeting apoptotic cells undergoing apoptosis and a use thereof. More particularly, it relates to a peptide having an amino acid sequence represented by anyone selected from the group consisting of SEQ ID NO: 1 to SEQ ID NO: 12 and targeting apoptotic cells, a composition for detection of apoptotic cells comprising the same as an effective ingredient, a composition for drug delivery comprising the same as an effective ingredient, a composition for imaging comprising the same as an effective ingredient and the like. The peptide of the present invention effectively detects apoptosis which is involved in tissues of neoplastic disease, myocardial infarction, stroke and arteriosclerosis. Accordingly, the peptide of the present invention may be used in imaging of diagnosis of the said diseases and reaction against a drug by binding imaging reagent and etc. as well as in protection and treatment for the said diseases by binding a treatment reagent and then delivering drug selectively.

    FUSION PEPTIDE COMPRISING DHFAS-1 DOMAIN AND MMP SUBSTRATE AND USE THEREOF FOR PREVENTING AND TREATING RHEUMATOID ARTHRITIS
    7.
    发明授权
    FUSION PEPTIDE COMPRISING DHFAS-1 DOMAIN AND MMP SUBSTRATE AND USE THEREOF FOR PREVENTING AND TREATING RHEUMATOID ARTHRITIS 有权
    与用于预防和治疗风湿性关节炎甲DHFAS-1结构域和MMP-SUBSTRATE及其用途融合肽

    公开(公告)号：EP2646473B1

    公开(公告)日：2017-02-15

    申请号：EP11845862.9

    申请日：2011-12-02

    申请人： Kyungpook National University Industry- Academic Cooperation Foundation

    发明人： KANG, Young Mo ,  KIM, In San ,  KANG, Jin Hee ,  SA, Keum Hee

    IPC分类号： C07K19/00 ,  C12N15/62 ,  A61K38/17 ,  A61P19/02

    CPC分类号： C07K14/435 ,  A61K38/00 ,  C07K14/475 ,  C07K2319/50 ,  C07K2319/74 ,  Y02A50/401

    摘要： The present invention relates to a fusion peptide comprising dhFas-1 domain and MMP substrate and use thereof. More specifically, the present invention relates to a fusion peptide, comprising a) a dhFas-1 domain which is the fourth fas-1 domain of βig-h3 lacking H1 and H2 regions; b) a MMP (Matrix metalloproteinase) substrate; and c) a peptide comprising RGD motif and an use thereof for preventing and treating inflammatory disease. The fusion peptide of the present invention inhibits expension of rheumatoid arthritis by adhesion and migration of sinoviocytes and may be used for preventing or treating inflammatory disease by inhibiting infiltration of immune cells.

    摘要翻译： 本发明涉及一种融合肽，其包含dhFas-1结构域和MMP的底物和其用途。 更具体地，本发明涉及一种融合肽，其包含a）dhFas-1结构域的所有这是第四FAS-1缺乏H1和H2区域的βIG-H3的结构域; b）一种MMP（基质金属蛋白酶）的底物; 和c）使用其用于预防和治疗炎性疾病的肽RGD基序和包括。 本发明的融合肽通过sinoviocytes的粘附和迁移抑制类风湿性关节炎和312104可以用于预防或抑制免疫细胞的浸润治疗炎性疾病。

    DRUG DELIVERY CONJUGATE CAPABLE OF CONTROLLED RELEASE, AND USE THEREOF
    8.
    发明公开
    DRUG DELIVERY CONJUGATE CAPABLE OF CONTROLLED RELEASE, AND USE THEREOF 审中-公开
    能够控制释放的药物递送共轭物及其用途

    公开(公告)号：EP2826492A1

    公开(公告)日：2015-01-21

    申请号：EP13761996.1

    申请日：2013-03-12

    申请人： Postech Academy-Industry Foundation ,  Kyungpook National University Industry-Academic Cooperation Foundation

    发明人： KIM, Won Jong ,  NAMGUNG, Ran ,  LEE, Byung Heon ,  KIM, In San ,  HOFFMAN, Allan

    IPC分类号： A61K47/40 ,  A61K47/48 ,  A61K47/30 ,  A61K31/337

    CPC分类号： A61K31/337 ,  A61K9/0019 ,  A61K9/5161 ,  A61K47/58 ,  A61K47/62 ,  A61K47/6951 ,  B82Y5/00

    摘要： The present invention relates to a hydrophobic drug delivery conjugate, to which cyclodextrin, poly(maleic anhydride), and a hydrophobic drug are bonded, and to a pharmaceutical composition comprising the hydrophobic drug delivery conjugate as an active ingredient. The hydrophobic drug delivery conjugate according to the present invention can effectively control the release rate and the delivery rate of a hydrophobic drug by regulating the physicochemical bonding and/or composition of the cyclodextrin, poly(maleic anhydride), and hydrophobic drug, and can also increase the effect of the drug by significantly increasing the solubility of the hydrophobic drug. Further, the present invention can enable the type of the hydrophobic drug to be varied, as well as a peptide having target directivity to be introduced into a surface of the conjugate, such that the present invention can be applied to the treatment of various diseases in addition to cancer treatment.

    摘要翻译： 本发明涉及与环糊精，聚（马来酸酐）和疏水性药物结合的疏水性药物递送缀合物，以及包含疏水性药物递送缀合物作为活性成分的药物组合物。 根据本发明的疏水性药物递送缀合物可以通过调节环糊精，聚（马来酸酐）和疏水性药物的物理化学键和/或组成来有效控制疏水性药物的释放速率和递送速率，并且还可以 通过显着增加疏水性药物的溶解度来增加药物的作用。 此外，本发明能够改变疏水性药物的类型以及将具有靶向性的肽引入缀合物的表面，使得本发明可以用于治疗 除了癌症治疗。

    POLYPEPTIDE SPECIFICALLY BINDING TO PHOSPHATIDYLSERINE AND USE THEREOF
    10.
    发明授权
    POLYPEPTIDE SPECIFICALLY BINDING TO PHOSPHATIDYLSERINE AND USE THEREOF 有权
    与特异性结合其使用磷脂酰丝氨酸多肽

    公开(公告)号：EP2280024B1

    公开(公告)日：2014-12-17

    申请号：EP09714117.0

    申请日：2009-02-25

    申请人： Kyungpook National University Industry- Academic Cooperation Foundation

    发明人： KIM, In San ,  LEE, Byung Heon ,  NARENDRA, Thapa

    IPC分类号： C07K7/06 ,  G01N33/574 ,  G01N33/92 ,  A61K47/48 ,  A61K49/00

    CPC分类号： G01N33/57492 ,  A61K47/64 ,  A61K49/0043 ,  C07K7/06 ,  G01N33/92 ,  G01N2405/04 ,  G01N2510/00 ,  Y02A50/58

    摘要： The present invention relates to a polypeptide specifically bound to phosphatidylserine and use thereof, and more particularly to a polypeptide having an amino acid sequence designated as sequence number 1 and specifically bound to phosphatidylserine, a phosphatidylserine detecting composition containing the polypeptide as an active ingredient, a detecting method of phosphatidylserine by using polypeptide, a apoptotic cell detecting containing the polypeptide as an active ingredient, a drug delivery composition containing the polypeptide as an active ingredient, a composition for treatment and prevention of a tumorous disease, and a composition for visualization of a tumorous region. A polypeptide having an amino acid sequence designated sequence number 1 is specifically bound to phosphatidylserine. Therefore, the polypeptide of the present invention is useful for detecting phosphatidylserine, furthermore detecting apoptotic cells expressing phosphatidylserine on the surface of the cell and tumor cells, and also useful for visualization of apoptotic cells or tumor cells.