公开(公告)号：EP2520281A2

公开(公告)日：2012-11-07

申请号：EP10841275.0

申请日：2010-12-29

申请人： Kyungpook National University Industry- Academic Cooperation Foundation ,  Industrial Technology Research Institute

发明人： KIM, In San ,  LEE, Byung Heon ,  LU, Maggie JM ,  LIANG, Hsiang-Fa ,  KO, Yi-Ju ,  LO, Ya-Chin ,  CHANG, Li-Wen ,  WEI, Ming-Cheng

IPC分类号： A61K9/127 ,  A61K47/30 ,  A61K47/18 ,  A61K38/20 ,  A61P35/00

CPC分类号： A61K31/704 ,  A61K9/1271 ,  A61K38/00 ,  A61K47/6911

摘要： The present invention relates to a target-aiming drug delivery system for diagnosis and treatment of cancer containing liposome labeled with peptides which specifically targets interleukin-4 receptors, and a manufacturing method thereof. The liposome which contains anticancer drugs labeled with IL4RPep peptides prepared in accordance with the present invention can deliver drugs to cancer cells in which IL-4 receptors are overexpressed by IL4RPep peptides which specifically bind to IL-4 receptors, and the drug delivery can recognize cancer cells specifically by a label. Thus, IL4RPep peptides can increase the effect of drugs only on cancer tissues and at the same time significantly reduce the side effects on normal tissues, which makes possible in vivo(molecular) imaging and early diagnosis of tumors. Therefore, the liposome which contains anticancer drugs labeled with IL4Pep peptides of the present invention can be applied, as the target-aiming drug delivery system, effectively to the diagnosis and treatment of cancers.

摘要翻译： 本发明涉及一种靶向药物递送系统，用于诊断和治疗标记与肽癌症含脂质体特异性靶向白介素-4受体，以及它们的制造方法。 其中包含标记有在雅舞蹈制备本发明可以对癌症细胞，在其中IL-4受体被IL4RPep缩氨酸肽过度表达的特异性结合IL-4受体的药物递送IL4RPep缩氨酸肽抗癌药物的脂质体，和药物递送可以识别癌 特别是通过一个标签的细胞。 因此，IL4RPep缩氨酸肽可以增加仅在癌组织和在Sametime大大减少对正常组织，在体内（分子）成像和肿瘤的早期诊断成为可能的副作用的药物的效果。 因此，其中包含与标记的本发明的肽IL4Pep抗癌药物脂质体可以应用，作为靶向药物递送系统，有效地对癌症的诊断和治疗。

公开(公告)号：EP2520281B1

公开(公告)日：2018-04-25

申请号：EP10841275.0

申请日：2010-12-29

申请人： Kyungpook National University Industry- Academic Cooperation Foundation ,  Industrial Technology Research Institute

发明人： KIM, In San ,  LEE, Byung Heon ,  LU, Maggie JM ,  LIANG, Hsiang-Fa ,  KO, Yi-Ju ,  LO, Ya-Chin ,  CHANG, Li-Wen ,  WEI, Ming-Cheng

IPC分类号： A61K47/69 ,  A61K9/127 ,  A61P35/00

CPC分类号： A61K31/704 ,  A61K9/1271 ,  A61K38/00 ,  A61K47/6911

摘要： The present invention relates to a target-aiming drug delivery system for diagnosis and treatment of cancer containing liposome labeled with peptides which specifically targets interleukin-4 receptors, and a manufacturing method thereof. The liposome which contains anticancer drugs labeled with IL4RPep peptides prepared in accordance with the present invention can deliver drugs to cancer cells in which IL-4 receptors are overexpressed by IL4RPep peptides which specifically bind to IL-4 receptors, and the drug delivery can recognize cancer cells specifically by a label. Thus, IL4RPep peptides can increase the effect of drugs only on cancer tissues and at the same time significantly reduce the side effects on normal tissues, which makes possible in vivo(molecular) imaging and early diagnosis of tumors. Therefore, the liposome which contains anticancer drugs labeled with IL4Pep peptides of the present invention can be applied, as the target-aiming drug delivery system, effectively to the diagnosis and treatment of cancers.

公开(公告)号：EP2279201A1

公开(公告)日：2011-02-02

申请号：EP09746749.2

申请日：2009-05-12

申请人： Kyungpook National University Industry- Academic Cooperation Foundation

发明人： LEE, Byung Heon ,  KIM, In San

IPC分类号： C07K7/06

CPC分类号： C07K7/06 ,  A61K38/00 ,  A61K47/64 ,  A61K49/0032 ,  A61K49/0043 ,  A61K49/0056 ,  C07K2319/33 ,  G01N2510/00

摘要： The present invention relates to a peptide capable of specifically targeting apoptotic cells undergoing apoptosis and a use thereof. More particularly, it relates to a peptide having an amino acid sequence represented by anyone selected from the group consisting of SEQ ID NO: 1 to SEQ ID NO: 12 and targeting apoptotic cells, a composition for detection of apoptotic cells comprising the same as an effective ingredient, a composition for drug delivery comprising the same as an effective ingredient, a composition for imaging comprising the same as an effective ingredient and the like. The peptide of the present invention effectively detects apoptosis which is involved in tissues of neoplastic disease, myocardial infarction, stroke and arteriosclerosis. Accordingly, the peptide of the present invention may be used in imaging of diagnosis of the said diseases and reaction against a drug by binding imaging reagent and etc. as well as in protection and treatment for the said diseases by binding a treatment reagent and then delivering drug selectively.

公开(公告)号：EP2280024B1

公开(公告)日：2014-12-17

申请号：EP09714117.0

申请日：2009-02-25

申请人： Kyungpook National University Industry- Academic Cooperation Foundation

发明人： KIM, In San ,  LEE, Byung Heon ,  NARENDRA, Thapa

IPC分类号： C07K7/06 ,  G01N33/574 ,  G01N33/92 ,  A61K47/48 ,  A61K49/00

CPC分类号： G01N33/57492 ,  A61K47/64 ,  A61K49/0043 ,  C07K7/06 ,  G01N33/92 ,  G01N2405/04 ,  G01N2510/00 ,  Y02A50/58

摘要： The present invention relates to a polypeptide specifically bound to phosphatidylserine and use thereof, and more particularly to a polypeptide having an amino acid sequence designated as sequence number 1 and specifically bound to phosphatidylserine, a phosphatidylserine detecting composition containing the polypeptide as an active ingredient, a detecting method of phosphatidylserine by using polypeptide, a apoptotic cell detecting containing the polypeptide as an active ingredient, a drug delivery composition containing the polypeptide as an active ingredient, a composition for treatment and prevention of a tumorous disease, and a composition for visualization of a tumorous region. A polypeptide having an amino acid sequence designated sequence number 1 is specifically bound to phosphatidylserine. Therefore, the polypeptide of the present invention is useful for detecting phosphatidylserine, furthermore detecting apoptotic cells expressing phosphatidylserine on the surface of the cell and tumor cells, and also useful for visualization of apoptotic cells or tumor cells.

公开(公告)号：EP2280024A2

公开(公告)日：2011-02-02

申请号：EP09714117.0

申请日：2009-02-25

申请人： Kyungpook National University Industry- Academic Cooperation Foundation

发明人： KIM, In San ,  LEE, Byung Heon ,  NARENDRA, Thapa

IPC分类号： C07K7/06

CPC分类号： G01N33/57492 ,  A61K47/64 ,  A61K49/0043 ,  C07K7/06 ,  G01N33/92 ,  G01N2405/04 ,  G01N2510/00 ,  Y02A50/58

摘要： The present invention relates to a polypeptide specifically bound to phosphatidylserine and use thereof, and more particularly to a polypeptide having an amino acid sequence designated as sequence number 1 and specifically bound to phosphatidylserine, a phosphatidylserine detecting composition containing the polypeptide as an active ingredient, a detecting method of phosphatidylserine by using polypeptide, a apoptotic cell detecting containing the polypeptide as an active ingredient, a drug delivery composition containing the polypeptide as an active ingredient, a composition for treatment and prevention of a tumorous disease, and a composition for visualization of a tumorous region. A polypeptide having an amino acid sequence designated sequence number 1 is specifically bound to phosphatidylserine. Therefore, the polypeptide of the present invention is useful for detecting phosphatidylserine, furthermore detecting apoptotic cells expressing phosphatidylserine on the surface of the cell and tumor cells, and also useful for visualization of apoptotic cells or tumor cells.

摘要翻译： 本发明涉及与磷脂酰丝氨酸特异性结合的多肽及其用途，更具体地说，涉及具有序列号1，特异性结合磷脂酰丝氨酸的氨基酸序列的多肽，含有多肽作为有效成分的磷脂酰丝氨酸检测组合物， 通过使用多肽检测磷脂酰丝氨酸的方法，检测含有多肽作为活性成分的凋亡细胞检测方法，含有多肽作为活性成分的药物递送组合物，用于治疗和预防肿瘤性疾病的组合物，以及用于 肿瘤区。 具有序列号1的氨基酸序列的多肽与磷脂酰丝氨酸特异性地结合。 因此，本发明的多肽可用于检测磷脂酰丝氨酸，此外还检测在细胞和肿瘤细胞表面上表达磷脂酰丝氨酸的凋亡细胞，并且还可用于凋亡细胞或肿瘤细胞的可视化。

公开(公告)号：EP2279201B1

公开(公告)日：2016-07-13

申请号：EP09746749.2

申请日：2009-05-12

申请人： Kyungpook National University Industry- Academic Cooperation Foundation

发明人： LEE, Byung Heon ,  KIM, In San

IPC分类号： C07K7/06

CPC分类号： C07K7/06 ,  A61K38/00 ,  A61K47/64 ,  A61K49/0032 ,  A61K49/0043 ,  A61K49/0056 ,  C07K2319/33 ,  G01N2510/00

公开(公告)号：EP2826492A1

公开(公告)日：2015-01-21

申请号：EP13761996.1

申请日：2013-03-12

申请人： Postech Academy-Industry Foundation ,  Kyungpook National University Industry-Academic Cooperation Foundation

发明人： KIM, Won Jong ,  NAMGUNG, Ran ,  LEE, Byung Heon ,  KIM, In San ,  HOFFMAN, Allan

IPC分类号： A61K47/40 ,  A61K47/48 ,  A61K47/30 ,  A61K31/337

CPC分类号： A61K31/337 ,  A61K9/0019 ,  A61K9/5161 ,  A61K47/58 ,  A61K47/62 ,  A61K47/6951 ,  B82Y5/00

摘要： The present invention relates to a hydrophobic drug delivery conjugate, to which cyclodextrin, poly(maleic anhydride), and a hydrophobic drug are bonded, and to a pharmaceutical composition comprising the hydrophobic drug delivery conjugate as an active ingredient. The hydrophobic drug delivery conjugate according to the present invention can effectively control the release rate and the delivery rate of a hydrophobic drug by regulating the physicochemical bonding and/or composition of the cyclodextrin, poly(maleic anhydride), and hydrophobic drug, and can also increase the effect of the drug by significantly increasing the solubility of the hydrophobic drug. Further, the present invention can enable the type of the hydrophobic drug to be varied, as well as a peptide having target directivity to be introduced into a surface of the conjugate, such that the present invention can be applied to the treatment of various diseases in addition to cancer treatment.

摘要翻译： 本发明涉及与环糊精，聚（马来酸酐）和疏水性药物结合的疏水性药物递送缀合物，以及包含疏水性药物递送缀合物作为活性成分的药物组合物。 根据本发明的疏水性药物递送缀合物可以通过调节环糊精，聚（马来酸酐）和疏水性药物的物理化学键和/或组成来有效控制疏水性药物的释放速率和递送速率，并且还可以 通过显着增加疏水性药物的溶解度来增加药物的作用。 此外，本发明能够改变疏水性药物的类型以及将具有靶向性的肽引入缀合物的表面，使得本发明可以用于治疗 除了癌症治疗。