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131.发明授权MIXTURE AND PHARMACEUTICAL COMPOSITION COMPRISING Z-4-HYDROXYTAMOXIFEN AND CYCLODEXTRIN 有权混合物，PHARMACEUTICAL制备含Z-4-羟基和环糊精
公开(公告)号：EP1043986B1
公开(公告)日：2003-04-16
申请号：EP98966848.8
申请日：1998-12-23
申请人： HEXAL AG
IPC分类号： A61K31/135 , A61K47/48
CPC分类号： A61K31/138
摘要： The invention concerns a mixture and a pharmaceutical composition consisting of or comprising Z-4-hydroxy-tamoxifen and at least one cyclodextrin.
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132.发明授权THYROXINE/CYCLODEXTRIN COMPLEXES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME 失效甲状腺素/ ZYKLODEXTRINKOMPLEXE及其药物制剂
公开(公告)号：EP0814844B1
公开(公告)日：2002-09-04
申请号：EP96941051.3
申请日：1996-11-28
申请人： HEXAL AG
发明人： FISCHER, Wilfried , BRACHER, Daniel
IPC分类号： A61K47/48
CPC分类号： A61K9/7061 , A61K9/7084 , A61K31/198 , A61K47/6951 , B82Y5/00
摘要： Thyroxine containing pharmaceutical compositions with improved aqueous solubility, stability and enhanced membrane permeation have been prepared by formulating thyroxine with cyclodextrins. These thyroxine/cyclodextrin complexes can further be transformed into different dosage forms (oral tablets, injectables, transdermal patches, hydrogels, ointments, suppositories, etc.) by employing known, common pharmaceutical additives.
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公开(公告)号：EP0817622B1
公开(公告)日：2001-11-28
申请号：EP96911973.4
申请日：1996-03-29
申请人： HEXAL AG
CPC分类号： A61K9/7053 , A61K9/7069 , A61K31/401 , A61K38/556
摘要： The invention concerns a transdermal system containing at least one ACE inhibitor.
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公开(公告)号：EP1150660A1
公开(公告)日：2001-11-07
申请号：EP00906318.1
申请日：2000-02-10
申请人： HEXAL AG
IPC分类号： A61K9/46 , A61K31/4152 , A61P29/00
CPC分类号： A61K9/0007 , A61K31/4152
摘要： The invention relates to a stable pharmaceutical effervescent formulation with metamizol and/or its pharmaceutically acceptable salts as active ingredients, wherein the pH of the corresponding solution is acidic.
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公开(公告)号：EP0833616B1
公开(公告)日：2001-10-04
申请号：EP96917391.3
申请日：1996-05-21
申请人： HEXAL AG
发明人： KNIDLBERGER, Astrid
CPC分类号： B01J2/12 , A61K9/1694 , A61K9/2077 , A61K9/209 , A61K9/2095 , B01J2/20
摘要： The invention concerns a process for the continuous agglomeration of granules intended for use in the production of compressed articles such as pharmaceutical preparations in tablet form.
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公开(公告)号：EP0813865B1
公开(公告)日：2001-09-19
申请号：EP97113342.6
申请日：1994-04-20
申请人： HEXAL AG
IPC分类号： A61K9/70
CPC分类号： A61K9/7061 , A61K9/7069 , A61K9/7084
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公开(公告)号：EP0848611B1
公开(公告)日：2001-07-18
申请号：EP96932478.9
申请日：1996-09-06
申请人： HEXAL AG
CPC分类号： A61K9/7061 , A61K9/7084 , A61K31/00
摘要： The invention relates to a patch for transdermal application with an outer covering layer, a self-adhesive matrix and a removable protective layer or with an outer covering layer, a reservoir, an adhesive component and a removable protective layer, wherein the matrix or the reservoir contains, as the active substance, tacrine or one of its pharmaceutically compatible salts.
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公开(公告)号：EP0921793B1
公开(公告)日：2000-10-18
申请号：EP98916917.2
申请日：1998-03-11
申请人： HEXAL AG
发明人： KLOKKERS, Karin
摘要： Non-deliquescent formulation comprising or consisting of sodium valproate and cyclodextrin having a molar ratio of sodium valproate to cyclodextrin within the range of from 1:0.01 to 1:0.09.
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139.发明公开
公开(公告)号：EP1009414A2
公开(公告)日：2000-06-21
申请号：EP98948878.8
申请日：1998-08-27
申请人： HEXAL AG
IPC分类号： A61K31/71
CPC分类号： A61K31/7036 , A61K9/0034 , A61K31/415 , A61K31/70 , A61K31/7034 , A61K45/06 , A61K2300/00
摘要： The invention relates to a new pharmaceutical composition containing clindamycin and clotrimazol used for the treatment of vaginal infections.
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公开(公告)号：EP0749304B1
公开(公告)日：1998-11-18
申请号：EP95913097.2
申请日：1995-03-13
申请人： HEXAL AG
发明人： FISCHER, Wilfried , KLOKKERS, Karin
CPC分类号： A61K9/209 , A61K9/2054 , A61K31/196
摘要： The invention concerns a slow-release tablet containing diclofenac-Na as the active ingredient and methylhydroxypropylcellulose as the retarding agent.
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