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公开(公告)号：EP2266553A1
公开(公告)日：2010-12-29
申请号：EP09730460.4
申请日：2009-03-24
IPC分类号： A61K31/137 , A61K9/70 , A61K47/10 , A61K47/14 , A61P31/10
CPC分类号： A61K31/137 , A61K8/0208 , A61K8/345 , A61K8/37 , A61K8/41 , A61K8/411 , A61K9/7053 , A61K9/7061 , A61K47/10 , A61K47/14 , A61Q3/00 , A61Q17/005
摘要： An aqueous patch is provided which has excellent storage stability and provides excellent retention of butenafine hydrochloride blended therein onto the application sites such as skin and nails and is highly therapeutic. The butenafine hydrochloride-containing aqueous patch includes butenafine hydrochloride, glycol salicylate, and propylene glycol in a hydrogel paste. Specifically, the butenafine hydrochloride-containing aqueous patch is produced by dissolving butenafine hydrochloride in a mixed solution of glycol salicylate and propylene glycol and dispersing the resulting solution in a hydrogel is provided. In particular, in the butenafine hydrochloride-containing aqueous patch, glycol salicylate and propylene glycol are mixed in a ratio of 1:2 to 1:30.
摘要翻译： 提供了一种水性贴剂，其具有优异的储存稳定性，并且在其中掺入的布替萘芬盐酸盐优异地保留在皮肤和指甲等施用部位上，并且是高度治疗性的。 含布替萘芬盐酸盐的水性贴剂包括水凝胶糊剂中的盐酸布替萘芬，水杨酸乙二醇酯和丙二醇。 具体而言，通过将布替萘芬盐酸盐溶解在水杨酸乙二醇酯和丙二醇的混合溶液中并将所得溶液分散在水凝胶中来制备含盐酸布替萘芬水性贴剂。 特别地，在含盐酸布替萘芬的水性贴剂中，水杨酸乙二醇酯和丙二醇以1:2至1:30的比例混合。
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公开(公告)号：EP2228063A1
公开(公告)日：2010-09-15
申请号：EP08860605.8
申请日：2008-12-11
发明人： TANI, Kazuha , AKAZAWA, Mitsuji
IPC分类号： A61K31/192 , A61K9/70 , A61K47/14
CPC分类号： A61K31/192 , A61K9/7061
摘要： An aqueous loxoprofen-containing patch is provided, which has good stability and excellent transdermal absorption of loxoprofen. The aqueous patch includes loxoprofen or a salt thereof and triacetin. Specifically, the aqueous patch includes, based on the weight of the adhesive gel base, 0.1 to 5% by weight of loxoprofen or a salt thereof, 0.5 to 5% by weight of triacetin, 1 to 30% by weight of a water-soluble polymer, 0.01 to 5% by weight of a cross-linking agent, 10 to 90% by weight of purified water, and 0 to 20% by weight of an inorganic powder.
摘要翻译： 提供了含有洛索洛芬的贴剂，其具有良好的稳定性和优异的洛索洛芬透皮吸收。 含水贴剂包括洛索洛芬或其盐和甘油三乙酸酯。 具体而言，所述水性贴剂包含基于所述粘性凝胶基质的重量为0.1至5重量％的洛索洛芬或其盐，0.5至5重量％的甘油三乙酸酯，1至30重量％的水溶性 聚合物，0.01-5重量％的交联剂，10-90重量％的纯化水和0-20重量％的无机粉末。
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公开(公告)号：EP1949895A1
公开(公告)日：2008-07-30
申请号：EP06823260.2
申请日：2006-11-09
发明人： GOTO, Takeshi , MORI, Kenji
IPC分类号： A61K31/137 , A61K9/08 , A61K31/167 , A61K45/00 , A61K47/32 , A61P23/02
CPC分类号： A61K45/06 , A61K9/0009 , A61K9/08 , A61K31/137 , A61K31/167
摘要： A preparation used for iontophoresis in order to absorb a physiologically active substance via the skin or mucosa using electrical driving force and the preparation containing a local anesthetic, epinephrine or its salt, water and chlorobutanol.
摘要翻译： 用于离子电渗疗法的制剂，以通过电驱动力通过皮肤或粘膜吸收生理活性物质，以及含有局部麻醉剂，肾上腺素或其盐，水和氯丁醇的制剂。
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公开(公告)号：EP0968713B1
公开(公告)日：2008-07-30
申请号：EP98919537.5
申请日：1998-05-11
CPC分类号： A61K9/7053 , A61K9/7061 , A61K9/7076 , A61K31/34 , A61K47/32
摘要： Patches containing isosorbide nitrate, having sufficient tackiness in the application thereof, and stabilized in the release of the drug after the application. The patches are characterized in that isosorbide nitrate is added as the active ingredient to tacky plasters containing as the essential ingredients styrene-isoprene-styrene block copolymers, rosin resins, liquid rubbers, antioxidants and oleic acid. More particularly, 15 to 25 % (w/w) of isosorbide nitrate is added to plasters containing 15 to 35 % of styrene-isoprene-styrene block copolymers, 35 to 55 % of rosin resins, 5 to 20 % of liquid rubbers, 0.1 to 2 % of antioxidants and 0.1 to 5 % of oleic acid.
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公开(公告)号：EP1889594A2
公开(公告)日：2008-02-20
申请号：EP07022865.5
申请日：1998-07-14
CPC分类号： A61Q19/00 , A61K8/0208 , A61K8/97 , A61K2800/242 , A61K2800/75
摘要： The present invention relates to external preparations containing a watercress extract which are excellent in the humectant effect and also capable of reducing skin irritation and giving a comfortableness of use even if a calefacient is blended. In particular, the present invention provides the external preparations containing a watercress extract with which one or more members selected from the group consisting of powdered capsicum, capsicum extract, capsicum tincture, capsaicin and nonanoic acid vanillylamide can be blended as calefacients.
摘要翻译： 本发明涉及含有水润保湿剂提取物的外用制剂，其保湿效果优异，并且即使配合调理剂也能够减少皮肤刺激并且使用舒适。 特别是，本发明提供含有选自粉末状辣椒，辣椒提取物，辣椒酊，辣椒素和壬酸香草酰胺中的一种或多种成分的西洋参提取物的外用制剂。
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公开(公告)号：EP0962226B1
公开(公告)日：2008-01-23
申请号：EP98931074.3
申请日：1998-07-14
发明人： YAMASAKI, Keiko , KONISHI, Tatsuya , SHUDO, Jutaro
CPC分类号： A61Q19/00 , A61K8/0208 , A61K8/97 , A61K2800/242 , A61K2800/75
摘要： External preparations containing watercress extract, which not only are excellent in humectant effect but also can give comfortableness in use with a lowering in the irritation to the skin even when they contain a calefacient. Specifically, external preparations characterized by containing a solvent extract of watercress and optionally further containing one or more calefacients selected from among powdered capsicum, capsicum extract, capsicum tincture, capsicin, and nonanoic vanillylamide.
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公开(公告)号：EP1557164A1
公开(公告)日：2005-07-27
申请号：EP04746246.0
申请日：2004-06-16
发明人： SHIRAI, Sadanobu , YAMAJI, Masahiro , YOSHIMOTO, Osamu , NARUSE, Mamoru , HATTORI, Kenichi , SUEDA, Takako, 101, Morimoto-No.5 building
IPC分类号： A61K31/137 , A61K47/12 , A61K47/32 , A61K9/70 , A61P11/08
CPC分类号： A61K9/7053 , A61K9/7076 , A61K31/137 , A61K47/12
摘要： A patch containing tulobuterol in the low concentration and having the stable release-controllability, prepared by laminating an adhesive layer consisting of a rubber, an adhesive resin and a plasticizer on a backing, wherein 1 to 4 w/w % of tulobuterol in the lower concentration as an active ingredient and 0.1 to 3 w/w % of a higher fatty acid as a drug-releasing controlling agent are contained in the adhesive layer.
摘要翻译： 通过将由橡胶，粘合剂树脂和增塑剂组成的粘合剂层层压在背衬上制备的含有低浓度的杜洛特罗并具有稳定的释放控制性的贴剂，其中在下部的1至4w / w％的十四氟醇 作为活性成分的浓度和作为药物释放控制剂的0.1〜3w / w％的高级脂肪酸被包含在粘合剂层中。
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公开(公告)号：EP1470101A1
公开(公告)日：2004-10-27
申请号：EP03703014.5
申请日：2003-01-22
IPC分类号： C07C237/20 , A61K31/165 , A61P25/04 , A61P43/00
CPC分类号： C07C237/20
摘要： A peptide derivative represented by the following formula (1) or a salt thereof;, wherein R1 is hydrogen atom or methyl group, R2 is hydrogen atom or hydroxy group and n is an integer of 1-8, provided that R1 is hydrogen atom when R2 is hydrogen atom, which has specific and high binding affinity with the μ-opioid receptor.
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公开(公告)号：EP1300143A1
公开(公告)日：2003-04-09
申请号：EP01934446.4
申请日：2001-05-31
IPC分类号： A61K31/192
CPC分类号： A61K9/7053 , A61K31/192
摘要： It is provided the plaster of anti-inflammatory and analgesic, improving the sustained releasing of 4-biphenylacetic acid from the base adhesive material and low skin irritation, by using more than two kinds of resolvent for 4-biphenylacetic acid having low solubility in solvents. More specifically, it is provided plasters essentially containing 5-50% by weight of styrene-isoprene-styrene block copolymer, 0.05-20% by weight of N-methyl-2-pyrrolidone, 0.1-20% by weight of polyethylene glycol and 0.1-20% by weight of 4-biphenylacetic acid.
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140.发明公开A stable external preparation containing aspirin 失效Stabile Zubereitung auf Basis von Aspirin zuräusserenAnwendung
公开(公告)号：EP1273300A3
公开(公告)日：2003-01-29
申请号：EP02021780.8
申请日：1998-06-23
IPC分类号： A61K47/24
CPC分类号： A61K9/0014 , A61K9/7053 , A61K9/7061 , A61K9/7076 , A61K31/616 , A61K47/06 , A61K47/14 , A61K47/18 , A61K47/34 , A61K47/44
摘要： External preparations containing Aspirin which are stored for a long term and superior in dermal absorbability. The preparations are prepared by mixing Aspirin together with silicon oil.
摘要翻译： 含有阿司匹林的外用制剂，其长期储存并具有优异的皮肤吸收性。 通过将阿司匹林与硅油混合制备制剂。
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