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公开(公告)号：EP1300143B1
公开(公告)日：2007-04-11
申请号：EP01934446.4
申请日：2001-05-31
IPC分类号： A61K31/192 , A61K9/70
CPC分类号： A61K9/7053 , A61K31/192
摘要： An anti-inflammatory analgesic patch which contains 4-biphenylacetic acid, which is a sparingly soluble anti-inflammatory analgesic, and two or more drug resolvents and which is hence improved in the releasability of 4-biphenylacetic acid from the base and in the sustained release thereof and is reduced in skin irritation. The patch contains as essential ingredients 5 to 50 wt.% styrene/isoprene/styrene block copolymer, 0.05 to 20 wt.% N-methyl-2-pyrrolidone, 0.1 to 20 wt.% polyethylene glycol, and 0.1 to 20 wt.% 4-biphenylacetic acid.
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公开(公告)号：EP0968710A1
公开(公告)日：2000-01-05
申请号：EP98919538.3
申请日：1998-05-11
IPC分类号： A61K9/70
CPC分类号： A61K9/7053 , A61K9/7061 , A61K9/7076
摘要： Patch preparations for percutaneous absorption with the use of supports showing an appropriate strength as a patch support, which are excellent in drug barrier characteristics, compatibility with the skin, ODT effects and handling characteristics and can sustain these specific properties in a stable state over a prolonged period of time, thus ensuring good percutaneous absorption of drugs. In these patch preparation, use is made as the support of polyester film/nonwoven vinylon fabric laminates showing an elongation percentage of at least 5 % and a tensile cutting load of at least 0.5 kg/10 mm, when measured by the test method specified in JIS K6732. In particular, the thickness of the polyester film constituting the laminate supports ranges from 1.5 to 6.0 µm and the unit weight of the nonwoven vinylon fabric ranges from 3 to 12 g/m 2 .
摘要翻译： 使用具有适当强度的支持物作为贴剂支持物的经皮吸收贴剂制剂，其具有优异的药物屏障特性，与皮肤的相容性，ODT效应和处理特性，并且可以长时间保持稳定状态下的这些特定性质 一段时间，从而保证药物良好的经皮吸收。 在这些贴剂制备中，使用如下测量方法作为支持聚酯薄膜/非织造维尼纶织物层压材料，该层压材料显示出至少5％的伸长率和至少0.5kg / 10mm的拉伸切割负荷， JIS K6732。 特别地，构成层压支撑体的聚酯膜的厚度为1.5〜6.0μm，无纺维尼纶织物的单位重量为3〜12g / m 2。
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公开(公告)号：EP0968713B1
公开(公告)日：2008-07-30
申请号：EP98919537.5
申请日：1998-05-11
CPC分类号： A61K9/7053 , A61K9/7061 , A61K9/7076 , A61K31/34 , A61K47/32
摘要： Patches containing isosorbide nitrate, having sufficient tackiness in the application thereof, and stabilized in the release of the drug after the application. The patches are characterized in that isosorbide nitrate is added as the active ingredient to tacky plasters containing as the essential ingredients styrene-isoprene-styrene block copolymers, rosin resins, liquid rubbers, antioxidants and oleic acid. More particularly, 15 to 25 % (w/w) of isosorbide nitrate is added to plasters containing 15 to 35 % of styrene-isoprene-styrene block copolymers, 35 to 55 % of rosin resins, 5 to 20 % of liquid rubbers, 0.1 to 2 % of antioxidants and 0.1 to 5 % of oleic acid.
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公开(公告)号：EP1557164A1
公开(公告)日：2005-07-27
申请号：EP04746246.0
申请日：2004-06-16
发明人： SHIRAI, Sadanobu , YAMAJI, Masahiro , YOSHIMOTO, Osamu , NARUSE, Mamoru , HATTORI, Kenichi , SUEDA, Takako, 101, Morimoto-No.5 building
IPC分类号： A61K31/137 , A61K47/12 , A61K47/32 , A61K9/70 , A61P11/08
CPC分类号： A61K9/7053 , A61K9/7076 , A61K31/137 , A61K47/12
摘要： A patch containing tulobuterol in the low concentration and having the stable release-controllability, prepared by laminating an adhesive layer consisting of a rubber, an adhesive resin and a plasticizer on a backing, wherein 1 to 4 w/w % of tulobuterol in the lower concentration as an active ingredient and 0.1 to 3 w/w % of a higher fatty acid as a drug-releasing controlling agent are contained in the adhesive layer.
摘要翻译： 通过将由橡胶，粘合剂树脂和增塑剂组成的粘合剂层层压在背衬上制备的含有低浓度的杜洛特罗并具有稳定的释放控制性的贴剂，其中在下部的1至4w / w％的十四氟醇 作为活性成分的浓度和作为药物释放控制剂的0.1〜3w / w％的高级脂肪酸被包含在粘合剂层中。
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公开(公告)号：EP1300143A1
公开(公告)日：2003-04-09
申请号：EP01934446.4
申请日：2001-05-31
IPC分类号： A61K31/192
CPC分类号： A61K9/7053 , A61K31/192
摘要： It is provided the plaster of anti-inflammatory and analgesic, improving the sustained releasing of 4-biphenylacetic acid from the base adhesive material and low skin irritation, by using more than two kinds of resolvent for 4-biphenylacetic acid having low solubility in solvents. More specifically, it is provided plasters essentially containing 5-50% by weight of styrene-isoprene-styrene block copolymer, 0.05-20% by weight of N-methyl-2-pyrrolidone, 0.1-20% by weight of polyethylene glycol and 0.1-20% by weight of 4-biphenylacetic acid.
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公开(公告)号：EP1833471B1
公开(公告)日：2015-03-25
申请号：EP04807500.6
申请日：2004-12-15
IPC分类号： A61K9/70 , A61K31/245
CPC分类号： A61K31/24 , A61K9/7053 , A61K9/7076 , A61K31/245 , A61K47/14 , A61K47/18
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公开(公告)号：EP2491931A1
公开(公告)日：2012-08-29
申请号：EP10824887.3
申请日：2010-10-18
IPC分类号： A61K31/445 , A61K9/08 , A61K9/70 , A61K47/10 , A61K47/14 , A61K47/22 , A61K47/34 , A61P25/28
CPC分类号： A61K31/445 , A61K9/7053
摘要： Provided is a donepezil-containing transdermal absorption formulation that can sustainably administer donepezil for a long period of time, and can provide both a rapid increase in the blood level of donepezil and donepezil sustained release properties. The donepezil-containing transdermal absorption formulation is a transdermal absorption formulation produced by dissolving donepezil, which is the active ingredient, in an adhesive patch base that contains a hydrophobic polymer and an absorption promoter. The absorption promoter is one kind or two or more kinds selected from lauryl alcohol, triethyl citrate, isopropyl myristate, cetyl lactate, oleyl alcohol, sorbitan monooleate, polyethylene glycol monostearate, lauromacrogol, N-methyl-2-pyrrolidone, and triacetin.
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公开(公告)号：EP1623711B1
公开(公告)日：2007-11-21
申请号：EP04732726.7
申请日：2004-05-13
IPC分类号： A61K31/565 , A61K31/57 , A61K9/70 , A61P3/06 , A61P5/30 , A61P9/10 , A61P15/12 , A61P19/10 , A61P25/28 , A61P29/00
CPC分类号： A61K9/7053 , A61K9/7076 , A61K31/565 , A61K31/57 , A61L15/585 , A61K2300/00 , C08L39/06 , C08L53/02
摘要： An external patch capable of stable prolonged release and transdermal absorption of active ingredient hormones (estrogens and/or progestogens) contained in a pressure sensitive adhesive layer, which external patch ensures low irritation on the skin. In particular, an external patch comprising a support and, superimposed thereon, a pressure sensitive adhesive layer, characterized in that the pressure sensitive adhesive layer comprises, as indispensable components, 5 to 50 wt.% of styrene/isoprene/styrene block copolymer, 20 to 70 wt.% of tackifier resin, 10 to 60 wt.% of softener and 1 to 20 wt.% of polyvinylpyrrolidone and contains, as an active ingredient, estrogen and/or progestogen.
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公开(公告)号：EP0950408B1
公开(公告)日：2001-10-04
申请号：EP98931077.6
申请日：1998-07-14
IPC分类号： A61K31/19 , A61K47/12 , A61K9/70 , A61K31/195
CPC分类号： A61K9/7053 , A61K9/7076 , A61K31/196 , A61K47/12
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公开(公告)号：EP1833471A1
公开(公告)日：2007-09-19
申请号：EP04807500.6
申请日：2004-12-15
IPC分类号： A61K9/70 , A61K31/245
CPC分类号： A61K31/24 , A61K9/7053 , A61K9/7076 , A61K31/245 , A61K47/14 , A61K47/18
摘要： The present invention provides to patches having excellent skin-permeability and therapeutic effect by the drug with lower irritation. In an external patch in which an adhesive layer containing an adhesive base and a drug are laminated with a backing, the external patch wherein the adhesive base contains 5-50 % by weight of synthetic rubber polymer, 10-60 % by weight of adhesive resin and 25-60 % by weight of liquid paraffin, and the drug is etofenamate. According to the present invention, there is obtainable the patches having excellent skin-permeability and therapeutic effect by the drug with lower irritation.
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