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131.发明授权METHOD FOR DIFFERENTIALLY QUANTIFYING NATURALLY PROCESSED HLA-RESTRICTED PEPTIDES FOR CANCER, AUTOIMMUNE AND INFECTIOUS DISEASES IMMUNOTHERAPY DEVELOPMENT 有权用于区分自然加工的HLA限制性肽用于癌症，自身免疫和感染性疾病免疫治疗发展的方法
公开(公告)号：EP2558867B1
公开(公告)日：2017-12-06
申请号：EP11714563.1
申请日：2011-04-15
发明人： WEINSCHENK, Toni , FRITSCHE, Jens
IPC分类号： G01N33/68
CPC分类号： G01N33/56977 , G01N33/6842 , G01N33/6848 , G01N33/6878 , G01N2333/70539 , Y02A90/24
摘要： The invention relates to a method for quantitatively identifying relevant HLA-bound peptide antigens from primary tissue specimens on a large scale without labeling approaches. This method can not only be used for the development of peptide vaccines, but is also highly valuable for a molecularly defined immunomonitoring and the identification of new antigens for any immunotherapeutic strategy in which HLA-restricted antigenic determinants function as targets, such as a variety of subunit vaccines or adoptive T-cell transfer approaches in cancer, or infectious and autoimmune diseases.
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132.发明授权
公开(公告)号：EP2178557B1
公开(公告)日：2017-03-01
申请号：EP08785105.1
申请日：2008-07-25
发明人： SINGH, Harpreet , SCHOOR, Oliver , TRAUTWEIN, Claudia , HILF, Norbert , WEINSCHENK, Toni , WALTER, Steffen , LEWANDROWSKI, Peter
CPC分类号： A61K39/0011 , A61K38/193 , A61K45/06 , A61K2039/5158 , A61K2039/53 , A61K2039/572 , C07K14/4748 , A61K2300/00
摘要： The present invention relates to immunotherapeutic peptides and their use in immunotherapy, in particular the immunotherapy of cancer. The present invention discloses tumour-associated T-helper cell peptide epitopes, alone or in combination with other tumour-associated peptides that serve as active pharmaceutical ingredients of vaccine compositions which stimulate anti-tumour immune responses. In particular, the composition of the peptides of the present invention can be used in vaccine compositions for eliciting anti-tumour immune responses against colorectal cancer.
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133.发明公开NOVEL IMMUNOTHERAPY AGAINST SEVERAL TUMORS INCLUDING NEURONAL AND BRAIN TUMORS 审中-公开新型免疫疗法针对不同肿瘤，包括神经和脑肿瘤
公开(公告)号：EP3120869A1
公开(公告)日：2017-01-25
申请号：EP16179192.6
申请日：2009-09-28
发明人： SCHOOR, Oliver , HILF, Norbert , WEINSCHENK, Toni , TRAUTWEIN, Claudia , WALTER, Steffen , SINGH, Harpreet
摘要： The present invention relates to peptides, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated cytotoxic T cell (CTL) peptide epitopes, alone or in combination with other tumor-associated peptides that serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses. The present invention relates to 30 peptide sequences and their variants derived from HLA class I and class II molecules of human tumor cells that can be used in vaccine compositions for eliciting anti-tumor immune responses.
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134.发明公开NOVEL IMMUNOTHERAPY AGAINST SEVERAL TUMORS INCLUDING NEURONAL AND BRAIN TUMORS 审中-公开新型免疫治疗包括神经元和脑肿瘤在内的多种肿瘤
公开(公告)号：EP3120868A1
公开(公告)日：2017-01-25
申请号：EP16179174.4
申请日：2009-09-28
发明人： SCHOOR, Oliver , HILF, Norbert , WEINSCHENK, Toni , TRAUTWEIN, Claudia , WALTER, Steffen , SINGH, Harpreet
摘要： The present invention relates to peptides, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated cytotoxic T cell (CTL) peptide epitopes, alone or in combination with other tumor-associated peptides that serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses. The present invention relates to 30 peptide sequences and their variants derived from HLA class I and class II molecules of human tumor cells that can be used in vaccine compositions for eliciting anti-tumor immune responses.
摘要翻译： 本发明涉及用于免疫治疗方法的肽，核酸和细胞。 具体而言，本发明涉及癌症的免疫治疗。 本发明还涉及单独或与其他肿瘤相关肽组合的肿瘤相关的细胞毒性T细胞（CTL）肽表位，所述肽用作刺激抗肿瘤免疫应答的疫苗组合物的活性药物成分。 本发明涉及30种肽序列及其衍生自可用于引发抗肿瘤免疫应答的疫苗组合物的人类肿瘤细胞的HLA I类和II类分子的肽序列及其变体。
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135.发明授权
公开(公告)号：EP2643698B1
公开(公告)日：2016-06-22
申请号：EP11788121.9
申请日：2011-11-22
IPC分类号： G01N33/574 , A61K39/00
CPC分类号： G01N33/57488 , G01N33/5011 , G01N33/574 , G01N2333/523 , G01N2333/775 , G01N2800/52
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136.发明授权Novel immunotherapy against neuronal and brain tumors 有权Neuartige Immuntherapie gegen Nerven- und Hirntumore
公开(公告)号：EP2105501B1
公开(公告)日：2015-10-07
申请号：EP08005889.4
申请日：2008-03-27
发明人： Emmerich, Niels , Singh, Harpreet , Schoor Oliver , Hilf, Norbert , Weinschenk, Toni , Trautwein, Claudia , Walter, Steffen
CPC分类号： C07K14/4748
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137.发明公开Novel immunotherapy against several tumors including gastrointestinal and gastric cancer 有权Neuartige Immuntherapie gegen verschiedene TumoreeinschließlichDarm- und Magenkrebs
公开(公告)号：EP2923708A1
公开(公告)日：2015-09-30
申请号：EP15154344.4
申请日：2011-03-15
CPC分类号： A61K38/1709 , A61K39/0011 , A61K2039/5158 , A61K2039/572 , A61K2039/585 , A61P35/00 , C07K7/06 , C07K2319/00 , G01N33/505
摘要： The present invention relates to peptides, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated cytotoxic T cell (CTL) peptide epitopes, alone or in combination with other tumor-associated peptides that serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses. The present invention relates to 95 novel peptide sequences and their variants derived from HLA class I molecules of human tumor cells that can be used in vaccine compositions for eliciting anti-tumor immune responses.
摘要翻译： 本发明涉及用于免疫治疗方法的肽，核酸和细胞。 特别地，本发明涉及癌症的免疫治疗。 本发明还涉及肿瘤相关的细胞毒性T细胞（CTL）肽表位，其单独或与作为刺激抗肿瘤免疫应答的疫苗组合物的活性药物成分的其它肿瘤相关肽的组合。 本发明涉及可用于引发抗肿瘤免疫应答的疫苗组合物中的95种新型肽序列及其衍生自人类肿瘤细胞HLA I类分子的变体。
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公开(公告)号：EP2183361B1
公开(公告)日：2015-06-10
申请号：EP08785107.7
申请日：2008-07-25
发明人： SCHOOR, Oliver , HILF, Norbert , WEINSCHENK, Toni , TRAUTWEIN, Claudia , WALTER, Steffen , SINGH, Harpreet
CPC分类号： A61K35/17 , A61K38/00 , C07K7/06 , C07K7/08 , C07K14/4748 , C12N5/0638
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139.发明公开Novel immunotherapy against several tumors including gastrointestinal and gastric cancer 有权对几种肿瘤，包括胃肠和胃癌新颖免疫疗法
公开(公告)号：EP2845604A3
公开(公告)日：2015-05-20
申请号：EP14184348.2
申请日：2011-03-15
CPC分类号： A61K38/1709 , A61K39/0011 , A61K2039/5158 , A61K2039/572 , A61K2039/585 , A61P35/00 , C07K7/06 , C07K2319/00 , G01N33/505
摘要： The present invention relates to peptides, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated cytotoxic T cell (CTL) peptide epitopes, alone or in combination with other tumor-associated peptides that serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses. The present invention relates to 95 novel peptide sequences and their variants derived from HLA class I molecules of human tumor cells that can be used in vaccine compositions for eliciting anti-tumor immune responses.
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140.发明公开Novel immunogenic epitopes for immunotherapy 有权Neuartige immunogenetische Epitope zur Immuntherapie
公开(公告)号：EP2565204A1
公开(公告)日：2013-03-06
申请号：EP12191631.6
申请日：2008-07-25
发明人： Singh, Harpreet , Schoor, Oliver , Trautwein, Claudia , Hilf, Norbert , Weinschenk, Toni , Walter, Steffen , Lewandrowski, Peter
IPC分类号： C07K14/47 , A61K39/00 , C07K14/495
CPC分类号： A61K39/0011 , A61K35/17 , A61K2039/5158 , A61K2039/572 , C07K7/06 , C07K7/08 , C07K14/47 , C07K14/4748 , C07K14/495 , C07K14/7051 , C07K16/40 , C07K19/00 , C07K2317/34 , C07K2319/00 , C12N5/0638 , C12N9/0036 , C12N9/13 , C12N2502/1157 , C12Y208/02011
摘要： The present invention relates to amino acid sequences of peptides derived from tumour associated antigens that are able to bind to MHC complexes of either class, and elicit an immune response, as well as to uses of said peptides for the treatment of diseases.
摘要翻译： 本发明涉及能够结合任一类MHC复合物并引发免疫应答的衍生自肿瘤相关抗原的肽的氨基酸序列，以及所述肽用于治疗疾病的用途。
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