摘要:
The present invention relates to a water-soluble binder composition comprising at least one carbohydrate component and at least one carbon dioxide reaction product comprising at least the reaction product(s) of carbon dioxide with at least one nitrogen-containing compound. It further relates to a method of its manufacture, its use, a method of manufacturing a collection of matter bound by said polymeric binder, as well as a binder solution or dispersion comprising said binder composition.
摘要:
The present invention relates to a water-soluble binder composition comprising at least one carbohydrate component and at least one carbon dioxide reaction product comprising at least the reaction product(s) of carbon dioxide with at least one nitrogen-containing compound. It further relates to a method of its manufacture, its use, a method of manufacturing a collection of matter bound by said polymeric binder, as well as a binder solution or dispersion comprising said binder composition.
摘要:
A method of diversification of human milk oligosaccharides (HMOs) or precursors thereof, compounds obtainable by the method, and uses and compositions involving such compounds. The method comprises the steps of a) providing at least one compound or a mixture of the compounds selected from the group consisting of: - optionally sialylated and/or fucosylated lactose derivatives of general formula 2 and salts thereof:
wherein R is a group removable by hydrogenolysis, R 1 independently of each other is fucosyl or H R 4 independently of each other is sialyl or H, provided that the compound of general formula 2 is not R-glycoside of lactose, if provided alone;
- optionally sialylated and/or fucosylated lactose derivatives of general formula 4 and salts thereof:
wherein R 1 independently of each other is fucosyl or H R 4 independently of each other is sialyl or H, provided that the compound of general formula 4 is not lactose, if provided alone;
- lacto-N-tetraose (LNT):
- lacto-N-tetraose (LNT) derivatives of the following formula:
wherein R is a group removable by hydrogenolysis; - lacto-N-neotetraose (LNnT):
- lacto-N-neotetraose (LNnT) derivatives of the following formula:
wherein R is a group removable by hydrogenolysis;
b) adding at least one enzyme comprising a transglycosidase activity to the at least one compound or a mixture of compounds provided according to step a); and c) incubating the mixture obtained according to step b).
摘要:
The invention relates to a synthetic oligosaccharide representing part of the repeating unit of the Clostridium difficile glycopolymer PS-I and having the sequence of the pentasaccharide ±-L-Rha p -(1†’3)-²-D-Glc p -(1†’4)-[±-L-Rha p -(1†’3)]-±-D-Glc p -(1†’2)-±-D-Glc p or a synthetic fragment or derivative thereof. Preferably, the claimed synthetic oligosaccharide bears at least one linker L for conjugation to a carrier protein or for immobilization on a surface. Further aspects of the invention relate to advantageous methods for synthesizing said synthetic oligosaccharide and oligosaccharide-protein conjugate as well as to uses thereof, in particular as vaccines and diagnostic tools. A preferred method for synthesizing the pentasaccharide is shown below.
摘要:
The invention relates to new compounds of formulae:
Wherein: R 1 and R 2 can be independently H; a C 1 to C 6 alkyl including methyl, ethyl, propyl, butyl; aryl including phenyl, para-methoxyphenyl; or R 1 ,R 2 together with the carbon C-6 can be a cyclopentylidene or cyclohexylidene; each of these groups being substituted or not; and R 3 can be a C 1 to C 6 alkyl including methyl, ethyl, propyl, isopropyl, butyl, isobutyl, tert -butyl, pentyl; or aryl including phenyl, methylphenyl, ethylphenyl, each of these groups being substituted or not. The invention also relates to their method of manufacture and their use for the synthesis of Ara-N 3 , Kdo-N 3 and 4eKdo-N 3 .