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公开(公告)号：EP2970353B1
公开(公告)日：2018-04-18
申请号：EP14721598.2
申请日：2014-03-12
发明人： DIETRICH, Evelyne , POISSON, Carl , GALLANT, Michel , LESSARD, Stephanie , LIU, Bingcan , DAS, Sanjoy, Kumar , RAMTOHUL, Yeeman , REDDY, Thumkunta, Jagadeeswar , MARTEL, Julien , VALLEE, Frederic , LEVESQUE, Jean-francois
IPC分类号： C07H15/203 , C07H15/20 , C07D493/10
CPC分类号： C07D493/10 , C07H15/18 , C07H15/20 , C07H15/203 , C07H15/207 , C07H15/22
摘要： The invention also provides processes for making the compounds described herein. Furthermore, the present invention provides a composition comprising the compounds described herein, and a pharmaceutically acceptable carrier, adjuvant, or vehicle. The present invention also provides methods of treating or preventing bacteria infection in a subject, comprising administering to the subject an effective amount of the compound or the composition described herein.
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公开(公告)号：EP2970354A2
公开(公告)日：2016-01-20
申请号：EP14762406.8
申请日：2014-03-18
发明人： PRAKASH, Indra , CHATURVEDULA, Venkata Sai Prakash , HIGIRO, Juvenal Higiro , AVETIK, Markosyan
IPC分类号： C07H15/24
CPC分类号： C07H15/256 , A23G4/10 , A23L2/60 , A23L27/00 , A23L27/36 , C07H1/00 , C07H1/06 , C07H13/08 , C07H15/20
摘要： The present invention relates generally to steviol glycosides, as well as compositions comprising such steviol glycosides. The present invention further extends to methods of preparing and purifying such steviol glycosides and methods for enhancing the flavor or sweetness of consumables using these steviol glycosides and compositions. The present invention extends to consumables comprising steviol glycosides, where the such steviol glycosides are present in a concentration at or below their sweetness recognition threshold, and wherein such steviol glycosides enhance the sweetness of the consumable.
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3.发明公开SMALL MOLECULE CONJUGATES FOR INTRACELLULAR DELIVERY OF BIOLOGICALLY ACTIVE COMPOUNDS 有权小分子偶联物生物活性化合物的细胞内输送
公开(公告)号：EP2658982A1
公开(公告)日：2013-11-06
申请号：EP11802425.6
申请日：2011-12-22
发明人： HADWIGER, Philipp , HOFFMANN, Torsten , JAHN-HOFMANN, Kerstin , KITAS, Eric A. , LEWIS, David L. , MOHR, Peter , MUELLER, Hans Martin , OTT, Guenther , ROEHL, Ingo , ROZEMA, David B.
IPC分类号： C12N15/87 , C12N15/11 , A61K48/00 , A61K31/713 , A61K47/18
CPC分类号： A61K38/00 , A61K31/7088 , A61K47/60 , A61K47/65 , A61K48/00 , C07C69/96 , C07C271/20 , C07H15/04 , C07H15/20 , C07H15/26 , C07K7/02 , C07K2317/77 , C12N15/1138 , C12N15/87 , C12N2310/14 , C12N2310/321 , C12N2310/322 , C12N2310/351 , C12N2320/30
摘要： The invention provides use of novel compounds for delivery of nucleic acids, and conjugates of these compounds with nucleic acids. Further novel design criteria for chemically stabilized siRNA particular useful when covalently attached to said compounds and co-administered with a delivery polymer to achieve mRNA knock down in vivo are disclosed therein.
摘要翻译： 本发明提供了使用用于递送核酸的新的化合物，并与核酸合成的化合物的缀合物。 对于化学进一步新颖设计标准稳定的siRNA特别有用的。当共价连接至所述化合物和与递送聚合物共施用，以实现基因敲低在体内盘游离缺失。其中。
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公开(公告)号：EP1441224A2
公开(公告)日：2004-07-28
申请号：EP04000298.2
申请日：2004-01-09
发明人： Ghoshal, Mitali , Sigler, Gerald , Hui, Raymond A. , Hawley, Ronald , Hoess, Eva , Huber, Erasmus J. , Patterson, John W. , Salamone, Salvatore J. , Dorn, Allan
IPC分类号： G01N33/53 , C12Q1/32 , C07D307/88 , C07J41/00 , C07D473/08
CPC分类号： C07D405/12 , C07D307/88 , C07D473/08 , C07H15/20 , C07H15/22 , C07H15/24 , C07J17/00 , C07J19/005 , C07J41/0005 , C07J41/0055 , C07J43/003 , G01N33/53 , G01N33/535 , G01N33/5735 , G01N33/581 , G01N33/78 , G01N33/9453 , G01N2333/904
摘要： The present invention provides a method for the measurement of an analyte in biological samples whereby an uncompetitive inhibitor is coupled to a ligand and utilized in a homogeneous assay. The analyte can be a drug or drug derivative, hormone, polypeptide, or oligonucleotide.
The present invention also provides novel compounds, assay reagents and packaged kits useful for performing such measurements.摘要翻译： 本发明提供了用于测量生物样品中的分析物的方法，由此使非竞争性抑制剂与配体偶联并用于均相测定。 分析物可以是药物或药物衍生物，激素，多肽或寡核苷酸。 本发明还提供了可用于进行这种测量的新型化合物，测定试剂和包装的试剂盒。
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公开(公告)号：EP1406913A2
公开(公告)日：2004-04-14
申请号：EP01934120.5
申请日：2001-05-11
IPC分类号： C07H11/04 , C07H5/06 , C07H15/207 , A61K31/7034 , A61P5/50
CPC分类号： C07H15/20
摘要： Compounds having a mimetic or antagonistic property of an inositol phosphoglycan, and the uses of these compounds are disclosed, together with the use, e.g. to treat a condition ameliorated by administration of an IPG second messenger or an IPG antagonist thereof. In particular, the compounds are based on the 1,6 linkage of a sugar residue and a cyclitol.
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公开(公告)号：EP0371495A2
公开(公告)日：1990-06-06
申请号：EP89122070.9
申请日：1989-11-29
申请人： MECT CORPORATION
发明人： Yoshimura, Shoji , Tanaka, Makoto
IPC分类号： C07H15/203 , C07H15/26 , A61K47/00
CPC分类号： C07H15/203 , A61K47/549 , C07H15/20
摘要： Sialic acid derivative with active ester groups expressed with the formula [I]
Where R 1 denotes hydrogen or acetyl group, R 2 hydrogen or lower alkyl group, R 3 C 2 H 4 , C 3 H 6 or C 2 H 2 , R 4 hydroxyl group, residue left after removing hydrogen from the alcohol portion of active ester or alkyloxycarbonyloxy group, Ac acetyl group, Ph phenyl group, X oxygen or sulfur. This sialic acid derivative has high reactivity because it has active ester groups in molecules and can be used as raw material or intermediate for synthesis of various sialic acid derivatives.摘要翻译： 其中R 1表示氢或乙酰基，R 2为氢或低级烷基，R 3为C 2 H 4，C 3 H 6或C 2 H 2，R 2为氢， 4个羟基，从活性酯或烷氧基羰氧基的醇部分除去氢后留下的残基，Ac乙酰基，Ph苯基，X氧或硫。 该唾液酸衍生物具有高反应性，因为它在分子中具有活性酯基，可用作合成各种唾液酸衍生物的原料或中间体。
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公开(公告)号：EP3337811A1
公开(公告)日：2018-06-27
申请号：EP16826986.8
申请日：2016-07-25
申请人： Wu, Rong-Tsun
发明人： HORNG, Lin-Yea
IPC分类号： C07H15/203 , A61K31/7034 , A61P7/06
CPC分类号： C07H15/203 , C07H15/20
摘要： Disclosed are compounds which can act as a positive allosteric modulator for erythropoietin and erythropoietin receptor and have the activity in promoting erythropoiesis. Also disclosed are pharmaceutical compositions comprising said compounds and treatment methods utilizing said compounds.
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公开(公告)号：EP2970354B1
公开(公告)日：2018-05-30
申请号：EP14762406.8
申请日：2014-03-18
CPC分类号： C07H15/256 , A23G4/10 , A23L2/60 , A23L27/00 , A23L27/36 , C07H1/00 , C07H1/06 , C07H13/08 , C07H15/20
摘要： The present invention relates generally to steviol glycosides, as well as compositions comprising such steviol glycosides. The present invention further extends to methods of preparing and purifying such steviol glycosides and methods for enhancing the flavor or sweetness of consumables using these steviol glycosides and compositions. The present invention extends to consumables comprising steviol glycosides, where the such steviol glycosides are present in a concentration at or below their sweetness recognition threshold, and wherein such steviol glycosides enhance the sweetness of the consumable.
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9.发明公开
公开(公告)号：EP3147367A1
公开(公告)日：2017-03-29
申请号：EP16184264.6
申请日：2011-08-04
发明人： HADWIGER, Philipp , HOFFMANN, Torsten , JAHN-HOFMANN, Kerstin , KITAS, Eric A. , LEWIS, David L. , MOHR, Peter , MUELLER, Hans Martin , OTT, Guenther , ROEHL, Ingo , ROZEMA, David B.
CPC分类号： A61K38/00 , A61K31/7088 , A61K47/60 , A61K47/65 , A61K48/00 , C07C69/96 , C07C271/20 , C07H15/04 , C07H15/20 , C07H15/26 , C07K7/02 , C07K2317/77 , C12N15/1138 , C12N15/87 , C12N2310/14 , C12N2310/321 , C12N2310/322 , C12N2310/351 , C12N2320/30
摘要： The invention provides use of novel compounds for delivery of nucleic acids, and conjugates of these compounds with nucleic acids. Further novel design criteria for chemically stabilized siRNA particular useful when covalently attached to said compounds and co-administered with a delivery polymer to achieve mRNA knock down in vivo are disclosed therein.
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公开(公告)号：EP2961412A4
公开(公告)日：2016-11-09
申请号：EP14756693
申请日：2014-02-26
发明人： WHITE THOMAS F , SMITH STEVEN
IPC分类号： A61K31/7034 , A61K31/517 , A61K31/5377 , A61K31/661 , A61K45/06 , C07F9/12 , C07H15/20 , C07H15/203
CPC分类号： C07H15/20 , A61K31/517 , A61K31/5377 , A61K31/661 , A61K31/662 , A61K31/7012 , A61K31/7034 , A61K45/06 , C07F9/12 , C07H15/203 , A61K2300/00
摘要： The present application relates to compositions and methods for treating a proliferative disorder by administering to a subject a pharmaceutical composition of a dual kinase inhibitor metabolite. Catecholic butane metabolites can serve as dual kinase inhibitors for purposes of methods described herein.
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