公开(公告)号：EP1585724A2

公开(公告)日：2005-10-19

申请号：EP04703042.4

申请日：2004-01-16

申请人： WISCONSIN ALUMNI RESEARCH FOUNDATION

发明人： DELUCA, Hector, F. ,  CLAGETT-DAME, Margaret ,  HIGHLAND, Margaret, A.

IPC分类号： C07C403/20 ,  C07J9/00

CPC分类号： C07C403/20 ,  A61K31/215 ,  C07C2601/16 ,  C07J9/00

摘要： A method of minimizing or reducing the toxicity of a retinoid having a free carboxyl group is described. The method comprises the step of esterifying the carboxyl group of the retinoid with a highly sterically hindered alcohol. The resulting retinoid esters are rendered much less toxic than the starting or parent retinoid. This process provides a retinoid ester analog of reduced toxicity so that it may be administered orally with minimal side effects and with a much greater therapeutic window.

摘要翻译： 描述了使具有游离羧基的类视黄醇的毒性最小化或降低的方法。 该方法包括用高度位阻的化合物（其优选为醇）酯化类视黄醇的羧基的步骤。 所得维生素A酯比起始或母体类视黄醇具有更少的毒性。 该方法提供了毒性降低的类视黄醇酯类似物，使得其可以以最小的副作用和更大的治疗窗口口服给药。

公开(公告)号：EP1394279B1

公开(公告)日：2005-08-24

申请号：EP02713191.1

申请日：2002-03-25

申请人： Japan Science and Technology Agency

发明人： SAITO, Yoshihiro ,  TSUJI, Nobuhiro ,  UEJI, Rintaro

IPC分类号： C22C38/00 ,  C21D8/00

CPC分类号： C22C38/02 ,  C21D1/25 ,  C21D8/02 ,  C21D8/0236 ,  C21D8/0273 ,  C21D2201/00 ,  C21D2211/005 ,  C21D2211/008 ,  C22C38/04

摘要： A high strength and high ductility low carbon steel product having a tensile strength of 800 MPa or more, a homogeneous elongation of 5 % or more, and an elongation at break of 20 % or more which is produced by a method comprising subjecting an ordinary low carbon steel or an ordinary low carbon steel added with B in an amount being 0.01 % or less and effective for accelerating martensitic transformation to working and heat treatment to prepare a product having roughened austenite crystal grains and then to cooling with water, to provide a steel product having a martensite phase in an amount of 90 % or more, and subjecting the steel product to a low strain working, specifically a cold rolling at a total rolling reduction of 20 % or more and less than 80 %, and to a low temperature annealing at 500 ° C to 600 ° C, to thereby form a hyperfine crystal grain ferrite structure having an average grain diameter of 1.0 µm or less; and a method for producing the steel product.

公开(公告)号：EP1426819A3

公开(公告)日：2005-05-04

申请号：EP03257603.5

申请日：2003-12-03

申请人： KONICA MINOLTA HOLDINGS, INC.

发明人： Okano, Satoshi ,  Kawashima, Kouki

IPC分类号： G03C7/42 ,  G03C7/44 ,  G03C5/26

CPC分类号： G03C7/42

摘要： A concentrated bleach-fixer composition for a silver halide color photographic material is disclosed, comprising an aminopolycarboxylic acid iron complex and a thiosulfate, wherein the bleach-fixer composition further comprises at least one compound selected from a phosphate salt, polyphosphate salt, an imidazole compound and a diaminotriazine compound; and the aminopolycarboxylic acid iron complex having a Fe(II) ratio of not less than 50 mol%.

公开(公告)号：EP1524264A2

公开(公告)日：2005-04-20

申请号：EP05001268.1

申请日：2001-05-31

申请人： WISCONSIN ALUMNI RESEARCH FOUNDATION

发明人： Deluca, Hector F. ,  Sicinski, Rafal R.

IPC分类号： C07C401/00 ,  A61K31/59

CPC分类号： C07C401/00

摘要： Biologically active 19-nor vitamin D analogs substituted at C-2 in the A-ring with an ethylidene group. These compounds have preferential activity on mobilising calcium from bone and either high or normal intestinal calcium transport activity which allows their in vivo administration for the treatment of metabolic bone diseases where bone loss is a major concern. These compounds are also characterised by high cell differentiation activity.

摘要翻译： 生物活性的19-或维生素D类似物在A环中被亚乙基取代为C-2。 这些化合物具有从骨骼中移动钙以及高或正常的钙运输活性的优先活性，其允许其体内施用以治疗骨质流失是主要关注的代谢性骨疾病。 这些化合物的特征还在于高细胞分化活性。

公开(公告)号：EP1518706A2

公开(公告)日：2005-03-30

申请号：EP04255853.6

申请日：2004-09-24

申请人： Konica Minolta Photo Imaging, Inc.

发明人： Watanabe, Hiroshi ,  Yamagishi, Hiroaki ,  Koyama, Hirokazu ,  Nakane, Hiroki

IPC分类号： B41M5/40 ,  B41M7/00

CPC分类号： B41M7/0027 ,  Y10T428/24802

摘要： Disclosed is a protective layer transfer sheet for forming an image by the method which comprising the steps of overlaying a thermal transfer image receiving sheet and a thermal transfer recording ink sheet, forming an image on the thermal diffusible dye receiving layer by heating, and forming a protective layer on the image by transferring the thermal transferable protective layer unit by heating, in which the thermal transferable protective layer unit is constituted by plural transferable resin layers and at least one of the resin layers contains a metal ion-containing compound and a layer other than the resin layer containing the metal ion-containing compound contains a UV absorbent, and a barrier layer is arranged between the metal ion-containing layer and the UV absorbent containing layer.

摘要翻译： 公开了一种用于通过以下方法形成图像的保护层转印片，该方法包括以下步骤：重叠热转印图像接收片和热转印记录油墨片，通过加热在热扩散性染料接收层上形成图像，并形成 保护层通过加热转印热转印保护层单元，其中可热转印保护层单元由多个可转印树脂层构成，并且至少一个树脂层含有含金属离子的化合物和其它层 比含有金属离子的化合物的树脂层含有紫外线吸收剂，并且在金属离子含有层和含紫外线吸收剂层之间配置有阻挡层。

公开(公告)号：EP1468822A3

公开(公告)日：2005-03-30

申请号：EP04252105.4

申请日：2004-04-08

申请人： Konica Minolta Medical & Graphic Inc.

发明人： Hiraoka, Saburou

IPC分类号： B41C1/10

CPC分类号： B41C1/1075

摘要： Disclosed is a developing process on a press of a planographic printing plate material comprising a hydrophilic layer and an image formation layer, which is capable of being developed with water or capable of being developed on a press, the process comprising the steps of (a) supplying dampening water to the planographic printing plate material with a recorded image mounted on a plate cylinder of a press by bringing a dampening roller into contact with the planographic printing plate material while rotating the plate cylinder, and (b) then supplying ink to the planographic printing plate material by bringing an ink roller into contact with the planographic printing plate material to remove an image formation layer unnecessary for printing, wherein in the step (a), the supplied amount of the dampening water is varied.

公开(公告)号：EP1513537A1

公开(公告)日：2005-03-16

申请号：EP03736949.3

申请日：2003-06-09

申请人： DUKE UNIVERSITY

发明人： BATINIC-HABERLE, Inesc/o Duke University ,  SPASOJEVIC, Ivanc/o Duke University ,  FRIDOVICH, Irwinc/o Duke University

IPC分类号： A61K31/555 ,  A61K31/409 ,  C07D487/22

CPC分类号： C07D487/22

摘要： A series of ortho isomers of meso tetrakis N-alkylpyridylporphyrins (alkyl being methyl, ethyl, n-propyl, n-butyl, n-hexyl, and n-octyl) and their Mn(III) complexes were synthesized and characterized by elemental analysis, uv/vis spectroscopy, electrospray ionization mass spectrometry and electrochemistry. An increase in the number of carbon atoms in the alkyl chains from 1 to 8 is accompanied by an increase in: (a) lipophilicity measured by the chromatographic retention factor, Rf; (b) metal-centered redox potential, E1/2 from +220 to +367 mV vs NHE, and (c) proton dissociation constant, pKa2 from 10.9 to 13.2. A linear correlation was found between E1/2 and Rf of the Mn(III) porphyrins and between the pKa2 and Rf of the metal-free compounds. As the porphyrins become increasingly more lipophilic, the decrease in hydration disfavors the separation of charges, while enhancing the electron-withdrawing effect of the positively charged pyridyl nitrogen atoms. Consequently, the E1/2 increases linearly with the increase in pKa2, a trend in porphyrin basicity opposite from the one we previously reported for other water-soluble Mn(III) porphyrins. All of these Mn(III) porphyrins are potent catalysts for superoxide dismutation (disproportionation). Despite the favorable increase of E1/2 with the increase in chain length, the catalytic rate constant decreases from methyl (log kcat = 7.79) to n-butyl, and then increases such that the n-octyl is as potent an SOD mimic as are the methyl and ethyl compounds. The observed behavior originates from an interplay of hydration and steric effects that modulate electronic effects.

公开(公告)号：EP1508564A1

公开(公告)日：2005-02-23

申请号：EP03730676.8

申请日：2003-05-28

申请人： Konica Minolta Chemical Co., Ltd.

发明人： IKEDA, Shin, c/o Konica Minolta Chemical Co., LTD ,  TAKAHASHI, Yasuhiro, Konica Minolta Chem. Co.,LTD

IPC分类号： C07C209/74

CPC分类号： C07C209/74 ,  C07C211/45

摘要： 2-benzylaniline can be manufactured in one-pot reaction at a substantially reduced cost by allowing 2-amino-5-halogenobenzophenone to react under a reductive condition.

摘要翻译： 2-苄基苯胺可以通过使2-氨基-5-卤代二苯甲酮在还原条件下反应，以大幅降低的成本在一锅反应中制备。

公开(公告)号：EP1498279A1

公开(公告)日：2005-01-19

申请号：EP04253552.6

申请日：2004-06-14

申请人： Konica Minolta Photo Imaging, Inc.

发明人： Kasahara, Kenzo c/o Konica Minolta P. Imaging, Inc

IPC分类号： B41M5/00

CPC分类号： B41M5/5227

摘要： A production method of a porous medium comprising a non-water-absorptive support and a porous layer provided on the support is disclosed. The method includes steps of,
   applying Water-based Composition A comprising inorganic microparticles of an average primary particle diameter of less than or equal to 30 nm, a hydrophilic binder and water onto the support to form a coated layer,
   drying the coated layer to form the porous layer, and
   applying Water-based Composition B onto the porous layer,
   and the Water-based Composition A further comprises a compound represented by Formula.

摘要翻译： 公开了一种包含非吸水性载体和设置在载体上的多孔层的多孔介质的制备方法。 该方法包括以下步骤：将包含平均一次粒径小于或等于30nm的无机微粒的水性组合物A，亲水性粘合剂和水施加到载体上以形成涂层，干燥涂层以形成 多孔层，将水性组合物B涂布在多孔层上，水性组合物A还含有式所表示的化合物。

公开(公告)号：EP1496914A1

公开(公告)日：2005-01-19

申请号：EP03714261.9

申请日：2003-03-20

申请人： WISCONSIN ALUMNI RESEARCH FOUNDATION

发明人： DELUCA, Hector, F. ,  SICINSKI, Rafal, R. ,  GRZYWACZ, Pawel K.

IPC分类号： A61K31/593 ,  A61P17/06 ,  A61P19/10 ,  A61P35/00 ,  A61P37/06

CPC分类号： C07C49/433 ,  A61K31/593 ,  C07C49/443

摘要： This invention discloses (20S)-1α-hydroxy-2α-methyl-19-nor-vitamin D3 and (20S)-1α-hydroxy-2β-methyl-19-nor-vitamin D3 and pharmaceutical uses therefor. These compounds exhibit pronounced activity in arresting the proliferation of undifferentiated cells and inducing their differentiation to the monocyte thus evidencing use as an anti-cancer agent and for the treatment of skin diseases such as psoriasis as well as skin conditions such as wrinkles, slack skin, dry skin and insufficient sebum secretion. These compounds also have very significant calcemic activity and therefore may be used to treat immune disorders in humans as well as metabolic bone diseases such as osteoporosis.