公开(公告)号：EP3518892B1

公开(公告)日：2023-06-21

申请号：EP17780865.6

申请日：2017-09-29

发明人： GERRING, David ,  HOWELL, Sarah ,  JEZEK, Jan ,  ZAKRZEWSKI, Leon

IPC分类号： A61K9/00 ,  A61K38/28 ,  A61K33/30 ,  A61K38/06 ,  A61P5/50 ,  A61P43/00 ,  A61P3/10

公开(公告)号：EP3592385B1

公开(公告)日：2022-05-04

申请号：EP18714446.4

申请日：2018-03-06

发明人： BADIALI, Luca ,  GERRING, David ,  JEZEK, Jan

IPC分类号： A61K39/395 ,  A61K47/18 ,  A61K47/26 ,  A61K9/08

公开(公告)号：EP3496734B1

公开(公告)日：2021-12-15

申请号：EP17754468.1

申请日：2017-08-11

发明人： GERRING, David ,  HOWELL, Sarah ,  JEZEK, Jan ,  ZAKRZEWSKI, Leon ,  WATTS, Gary

IPC分类号： A61K38/00 ,  A61K38/28 ,  A61K47/18 ,  A61K9/00 ,  A61P3/10

公开(公告)号：EP2968112A1

公开(公告)日：2016-01-20

申请号：EP14714307.7

申请日：2014-03-14

申请人： Arecor Limited

发明人： JEZEK, Jan ,  BUCKLER, Angela

IPC分类号： A61K9/00 ,  A61K47/36 ,  A61K48/00 ,  C12N15/86

CPC分类号： A61K47/38 ,  A61K9/0019 ,  A61K39/235 ,  A61K47/183 ,  A61K47/32 ,  A61K47/36 ,  A61K48/0008 ,  C07K14/005 ,  C12N7/00 ,  C12N15/86 ,  C12N2710/10343 ,  C12N2710/10351

摘要： The present invention is based on the surprising discovery that the inclusion of an anionic polymer in the adenovirus formulation enhances long-term stability of the vector composition. An aqueous formulation comprising an adenovirus vector and at least one anionic polymer is provided, together with methods of the preparation of a storage stable adenovirus aqueous formulation.

摘要翻译： 本发明基于令人惊奇的发现，即将阴离子聚合物包含在腺病毒制剂中可增强载体组合物的长期稳定性。 提供了包含腺病毒载体和至少一种阴离子聚合物的水性制剂，以及制备储存稳定性腺病毒水性制剂的方法。

公开(公告)号：EP2538967A1

公开(公告)日：2013-01-02

申请号：EP11706318.0

申请日：2011-02-24

申请人： Arecor Limited

发明人： JEZEK, Jan ,  DERHAM, Barry Kingston

IPC分类号： A61K38/36 ,  C12N9/64

CPC分类号： A61K38/4846 ,  A61K9/0019 ,  A61K47/26 ,  C12N9/644 ,  C12N9/96 ,  C12Y304/21022

摘要： The invention allows substantial improvements in stability of coagulation Factor IX in aqueous compositions. An aqueous composition sealed in a non-glass container comprising Factor IX in a buffer and calcium ions is provided, together with methods of stabilizing an aqueous Factor IX composition comprising storing said composition in a non-glass container for at least 7 days.

公开(公告)号：EP2473194A1

公开(公告)日：2012-07-11

申请号：EP10750159.5

申请日：2010-09-02

申请人： Arecor Limited

发明人： JEZEK, Jan ,  DERHAM, Barry Kingston

IPC分类号： A61K47/02 ,  A61K47/18 ,  A61K38/00 ,  G01N1/00

CPC分类号： A61K47/02 ,  A61K9/0019 ,  A61K9/08 ,  A61K9/19 ,  A61K38/00 ,  A61K47/183

摘要： The invention relates
inter
alia to a composition which is storage-stable at 25°C for a minimum of 18 weeks comprising a therapeutically effective amount of Factor VIII and an aqueous medium having a Factor VIII potency after 18 weeks of storage at 25° C of at least 90% of the Factor VIII potency of a Control Composition.

公开(公告)号：EP2328607A1

公开(公告)日：2011-06-08

申请号：EP09785344.4

申请日：2009-07-16

申请人： Arecor Limited

发明人： JEZEK, Jan

IPC分类号： A61K38/27 ,  A61K47/14 ,  A61K9/08

CPC分类号： A61K47/12 ,  A61K9/0019 ,  A61K38/00 ,  A61K38/27 ,  A61K47/18 ,  A61K47/183 ,  A61K47/26

摘要： An aqueous composition comprising a therapeutic protein further characterized in that (i) the pH of the composition is adjusted to be between about 5.9 and 6.3, preferably about 6.1; (ii) the composition comprises at least one displaced buffer having a pKa within 1 to 3 pH units of the pH of the composition such as lactate and TRIS; (iv) the osmolarity of the composition is between 150 - 500 mOsm/L.

公开(公告)号：EP2114456A2

公开(公告)日：2009-11-11

申请号：EP08700170.7

申请日：2008-01-11

申请人： Arecor Limited

发明人： JEZEK, Jan

IPC分类号： A61K47/18 ,  A61K47/14 ,  A61K47/22 ,  A61K38/44 ,  A61K38/27 ,  A61K39/29 ,  A61K9/08

CPC分类号： A61K39/292 ,  A61K38/21 ,  A61K38/27 ,  A61K38/28 ,  A61K38/36 ,  A61K38/44 ,  A61K38/443 ,  A61K39/12 ,  A61K39/39591 ,  A61K45/06 ,  A61K47/12 ,  A61K47/18 ,  A61K47/183 ,  A61K2039/55505 ,  A61K2039/55511 ,  C12N7/00 ,  C12N2730/10134 ,  C12Y101/03004 ,  C12Y107/03003 ,  C12Y111/01006 ,  Y02A50/39 ,  Y02A50/412 ,  Y02A50/464 ,  Y02A50/466

摘要： An aqueous composition having increased protein stability is obtained by: a. determining a pH at which the protein has stability at the desired temperature; b. adding to the composition at least one displacement buffer wherein the displacement buffer has a pKa that is at least 1 unit greater or less than the pH of step (a); and c. adjusting the pH of the composition to the pH of step (a); wherein the aqueous composition does not comprise a conventional buffer at a concentration greater than about 2 mM and wherein the conventional buffer has a pKa that is within 1 unit of the pH of step (a).

公开(公告)号：EP2113564A1

公开(公告)日：2009-11-04

申请号：EP08155538.5

申请日：2008-05-01

申请人： Arecor Limited

发明人： Jezek, Jan

IPC分类号： C12N9/96

CPC分类号： C12N9/96 ,  C07K14/32 ,  C07K14/57 ,  C12N9/0065 ,  C12Y111/01006 ,  C12Y111/01007 ,  Y10T436/143333

摘要： An aqueous composition which comprises
(i) a metalloprotein (or a protein whose structure is dependent on the presence of a metal);
(ii) ions of the metal at a concentration of 0 to 20 mM; and
(iii) excipients such as buffers and tonicity modifiers, that are relatively weak legands, the composition being substantially free of relatively strong ligands.

摘要翻译： 一种水性组合物，其包含（i）金属蛋白（或其结构取决于金属的存在的蛋白质）; （ii）浓度为0至20mM的金属离子; 和（iii）相对弱的配子，诸如缓冲剂和张力调节剂的赋形剂，组合物基本上不含相对较强的配体。

公开(公告)号：EP3585820A1

公开(公告)日：2020-01-01

申请号：EP18708465.2

申请日：2018-02-23

申请人： Arecor Limited

发明人： JEZEK, Jan ,  GERRING, David

IPC分类号： C07K16/30 ,  A61K39/395