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    POLYSACCHARIDES COMPRISING TWO ANTITHROMBIN III-BINDING SITES, PREPARATION THEREOF AND USE THEREOF AS ANTITHROMBOTIC MEDICAMENTS
    2.
    发明授权
    POLYSACCHARIDES COMPRISING TWO ANTITHROMBIN III-BINDING SITES, PREPARATION THEREOF AND USE THEREOF AS ANTITHROMBOTIC MEDICAMENTS 有权

    公开(公告)号：EP2697265B1

    公开(公告)日：2018-09-26

    申请号：EP12718395.2

    申请日：2012-04-11

    申请人： SANOFI

    发明人： MOURIER, Pierre ,  VISKOV, Christian

    IPC分类号： C08B37/00 ,  A61K31/727

    CPC分类号： A61K31/727 ,  A61K45/06 ,  B01D15/1878 ,  B01D15/34 ,  B01D15/363 ,  B01D15/3823 ,  C08B37/0075 ,  Y10T436/143333

    摘要： The invention relates to sulphated polysaccharides which have the general structure of the constituent polysaccharides of heparin and which have a molecular weight of less than 8000 Daltons, comprising two antithrombin III-binding hexasaccharide sequences corresponding to formula (I) in which: R1 represents an OH group when the hexasaccharide of formula (I) is located at the reducing end of the polysaccharide, or else R1 represents a bond with another saccharide unit of said polysaccharide; R2 represents a hydrogen atom when the hexasaccharide of formula (I) is located at the non-reducing end of the polysaccharide, in which case the bond between carbon atoms 4 and 5 of the first saccharide unit of said hexasaccharide is a double bond, or else R2 represents a bond with another saccharide unit of said polysaccharide, in which case the bond between carbon atoms 4 and 5 of the first saccharide unit is a single bond. Preparation thereof, use thereof as antithrombotic medicaments, and also use thereof in a method for analyzing a sample of a heparin derivative.

    METHOD OF DETECTING NUCLEIC ACIDS, METHOD OF OPTICALLY OBSERVING SAMPLE AND FLUORESCENT SUBSTANCE
    7.
    发明公开
    METHOD OF DETECTING NUCLEIC ACIDS, METHOD OF OPTICALLY OBSERVING SAMPLE AND FLUORESCENT SUBSTANCE 审中-公开
    检测核酸的方法，光学观察样品和荧光物质的方法

    公开(公告)号：EP3269810A1

    公开(公告)日：2018-01-17

    申请号：EP17170998.3

    申请日：2011-11-04

    申请人： Sony Corporation

    发明人： NITTA, Nao

    IPC分类号： C12N15/09 ,  C12Q1/68

    CPC分类号： C12Q1/6825 ,  C12Q1/6816 ,  C12Q1/6827 ,  G01N21/6486 ,  G01N2021/6421 ,  G01N2201/12 ,  Y10T436/143333 ,  C12Q2563/137

    摘要： [Object] A method of detecting nucleic acids easily without requiring complicated operations such as mixing of liquids and cleaning within micro-scale flow channels.
    [Solving Means] A method of detecting nucleic acids including the steps of bringing a sample containing the nucleic acids into contact with copper, and detecting fluorescence emitted from the sample is provided. According to the method of detecting nucleic acids, only by bringing the sample containing nucleic acids into contact with copper, the fluorescence derived from the composite of the nucleic acids and copper can be easily detected.

    摘要翻译： 本发明的目的在于提供一种不需要复杂的操作，例如混合液体并在微尺度流道内清洗的容易检测核酸的方法。 [解决手段]提供检测核酸的方法，包括使含有核酸的样品与铜接触以及检测从样品发出的荧光的步骤。 根据检测核酸的方法，仅通过使含有核酸的样品与铜接触，可以容易地检测由核酸与铜的复合物衍生的荧光。