公开(公告)号：EP1641486B1

公开(公告)日：2012-04-18

申请号：EP04773889.3

申请日：2004-06-07

申请人： LG Life Sciences Ltd.

发明人： KWON, Kyu Chan ,  CHOI, Suk Young ,  KANG, Young Cheol ,  JEH, Hoon Sung ,  LEE, Seung Joo ,  KIM, Myung Jin ,  KIM, Ji Eon, c/o LG Life Sciences Ltd. ,  Oh, Jin-Seok, c/o LG Life Sciences Ltd.

IPC分类号： A61K9/08 ,  A61K38/18 ,  A61K47/02 ,  A61K47/10 ,  A61K47/12 ,  A61K47/18 ,  A61K47/26

CPC分类号： A61K9/0019 ,  A61K38/1816 ,  A61K47/02 ,  A61K47/10 ,  A61K47/12 ,  A61K47/183 ,  A61K47/26

摘要： The present invention provides an aqueous formulation of human erythropoietin having the storage stability over a long period without serum albumin, in which the formulation comprises a pharmaceutically effective amount of human erythropoietin; non-ionic, polyhydric alcohol, neutral amino acid and sugar alcohol as stabilizers; isotonic reagent; and buffering reagent.

公开(公告)号：EP2024500B1

公开(公告)日：2012-02-01

申请号：EP07746891.6

申请日：2007-06-13

申请人： LG Life Sciences, Ltd.

发明人： KOH, Sang-seok ,  SONG, Si-young ,  KIM, Sun-a ,  LEE, Yang-soon ,  JEON, Sun-bok ,  PARK, Eui-chul ,  KIM, Young-gun

IPC分类号： C07K14/82 ,  G01N33/48 ,  G01N33/50

CPC分类号： C07K14/82

摘要： The invention relates generally to the changes in gene expression in human pancreatic adenocarcinoma. The invention relates specifically to a human gene family which is differentially expressed in cancerous pancreatic tissues compared to corresponding non-cancerous pancreatic tissues.

公开(公告)号：EP2350060A2

公开(公告)日：2011-08-03

申请号：EP09826254.6

申请日：2009-11-10

申请人： LG Life Sciences Ltd

发明人： LEE, Koo ,  LEE, Sang Dae ,  MOON, Sang Pil ,  AHN, In Ae ,  CHOI, Sung Pil ,  LEE, Hyun Ho ,  SHIM, Dong Sup ,  CHUNG, Soo Yong ,  LEE, Hyun Min

IPC分类号： C07D403/14

CPC分类号： C07D417/14 ,  A61K31/4025 ,  A61K31/496 ,  C07D207/16 ,  C07D401/14 ,  C07D403/06 ,  C07D405/14 ,  C07D409/14

摘要： The present invention relates to a compound having a good agonistic activity to melanocortin receptor, or pharmaceutically acceptable salt or isomer thereof, and an agonistic composition for melanocortin receptor comprising the same as an active ingredient.

公开(公告)号：EP2046757A4

公开(公告)日：2011-04-27

申请号：EP07793275

申请日：2007-07-27

申请人： LG LIFE SCIENCES LTD

发明人： CHANG HYE KYUNG ,  OH YEONG SOO ,  JANG YONG JIN

IPC分类号： C07D237/14 ,  C07D237/16 ,  C07D401/06 ,  C07D413/06 ,  C07D417/06 ,  C07F9/32

CPC分类号： C07D237/14 ,  C07D237/16 ,  C07D401/06 ,  C07D413/06 ,  C07D417/06

公开(公告)号：EP2271615A1

公开(公告)日：2011-01-12

申请号：EP09738936.5

申请日：2009-04-17

申请人： LG Life Sciences Ltd

发明人： HWANG, Kook Sang ,  CHUNG, Soon Min ,  KIM, Chang Ki ,  KIM, Bok Tae ,  LEE, Ju Young ,  KIM, Byeong Cheol ,  JOE, Goon Ho

IPC分类号： C07C231/02

CPC分类号： C07C231/02 ,  C07C235/68

摘要： The present invention relates to a novel process for preparing iopromide which is used as a contrast agent for X-ray, wherein 5-methoxyacetylamino-2,4,6-triiodoisophthalic acid (2,3-diacetoxypropyl)amide chloride of formula (19) and 5-methoxyacetylamino-2,4,6-triiodoisophthalic acid [(2,3-dihydroxy-N-methylpropyl)-(2,3-diacetoxypropyl)]diamide of formula (20) are introduced as intermediates, by which a bismer by-product generated during the preparation process can be removed even without an additional removal procedure and thus iopromide with high purity can be prepared in high yield.

公开(公告)号：EP2178870A1

公开(公告)日：2010-04-28

申请号：EP08793298.4

申请日：2008-08-18

申请人： LG Life Sciences Ltd.

发明人： KIM, Soon Ha ,  KIM, Hyoung Jin ,  KOO, Sun Young ,  CHUNG, Chul Woong ,  LEE, Sung Bae ,  PARK, Heui Sul ,  YOON, Seung Hyun ,  KWAK, Hyo Shin ,  SEO, Dong Ook ,  PARK, Eok

IPC分类号： C07D417/04 ,  C07D231/56 ,  C07D401/02 ,  A61P1/16 ,  A61P25/16 ,  A61P25/28 ,  A61P31/00 ,  A61P35/00 ,  A61P9/00 ,  A61P3/10

CPC分类号： C07D417/06 ,  A61K31/404 ,  A61K31/416 ,  A61K31/427 ,  A61K31/4439 ,  A61K31/445 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/496 ,  A61K31/497 ,  A61K31/5377 ,  A61K31/541 ,  A61K31/675 ,  A61K45/06 ,  C07D413/04 ,  C07D413/14 ,  C07D417/04 ,  C07D417/14 ,  C07D487/04 ,  C07F9/65583 ,  C07F9/65586

摘要： The present invention relates to indole or indazole compounds, pharmaceutically acceptable salts or isomers thereof which are useful for the prevention or treatment of cellular necrosis and necrosis-associated diseases. The present invention also relates to a method and a composition for the prevention or treatment of cellular necrosis and necrosis-associated diseases, comprising said indole or indazole compounds as an active ingredient.

公开(公告)号：EP2178869A1

公开(公告)日：2010-04-28

申请号：EP08793297.6

申请日：2008-08-18

申请人： LG Life Sciences Ltd.

发明人： KIM, Soon Ha ,  KIM, Hyoung Jin ,  KOO, Sun Young ,  LEE, Sung Bae ,  PARK, Heui Sul ,  YOON, Seung Hyun ,  PAEK, Seung Yup ,  KWAK, Hyo Shin ,  SEO, Dong Ook ,  PARK, Eok

IPC分类号： C07D417/04 ,  C07D209/10 ,  A61K31/404 ,  A61P1/16 ,  A61P25/16 ,  A61P25/28 ,  A61P3/10 ,  A61P31/00 ,  A61P35/00 ,  A61P9/00

CPC分类号： C07D417/06 ,  A61K31/404 ,  A61K31/416 ,  A61K31/427 ,  A61K31/4439 ,  A61K31/445 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/496 ,  A61K31/497 ,  A61K31/5377 ,  A61K31/541 ,  A61K31/675 ,  A61K45/06 ,  C07D413/04 ,  C07D413/14 ,  C07D417/04 ,  C07D417/14 ,  C07D487/04 ,  C07F9/65583 ,  C07F9/65586

摘要： The present invention relates to indole or indazole compounds, pharmaceutically acceptable salts or isomers thereof which are useful for the prevention or treatment of cellular necrosis and necrosis-associated diseases. The present invention also relates to a method and a composition for the prevention or treatment of cellular necrosis and necrosis-associated diseases, comprising said indole or indazole compounds as an active ingredient.

公开(公告)号：EP1851214A4

公开(公告)日：2009-10-28

申请号：EP06716026

申请日：2006-02-21

申请人： LG LIFE SCIENCES LTD

发明人： SHIN HYUN IK ,  CHOI HYEONG WOOK ,  HEO TAE HO ,  LEE KYU WOONG R D ,  LEE JAE HOON R D ,  PARK KI SOOK

IPC分类号： C07D413/12 ,  A61K31/422 ,  A61P29/00 ,  C07C229/08 ,  C07D413/14

CPC分类号： C07C229/22 ,  C07D413/12 ,  C07D413/14

公开(公告)号：EP1641486A4

公开(公告)日：2008-10-08

申请号：EP04773889

申请日：2004-06-07

申请人： LG LIFE SCIENCES LTD

发明人： KWON KYU CHAN ,  CHOI SUK YOUNG ,  KANG YOUNG CHEOL ,  JEH HOON SUNG ,  LEE SEUNG JOO ,  KIM MYUNG JIN ,  KIM JI EON ,  OH JIN-SEOK

IPC分类号： A61K9/08 ,  A61K47/30 ,  A61K9/00 ,  A61K38/16 ,  A61K38/18 ,  A61K47/02 ,  A61K47/10 ,  A61K47/12 ,  A61K47/18 ,  A61K47/26

CPC分类号： A61K9/0019 ,  A61K38/1816 ,  A61K47/02 ,  A61K47/10 ,  A61K47/12 ,  A61K47/183 ,  A61K47/26

摘要： The present invention provides an aqueous formulation of human erythropoietin having the storage stability over a long period without serum albumin, in which the formulation comprises a pharmaceutically effective amount of human erythropoietin; non-ionic, polyhydric alcohol, neutral amino acid and sugar alcohol as stabilizers; isotonic reagent; and buffering reagent.

公开(公告)号：EP1458390B1

公开(公告)日：2008-08-13

申请号：EP02795443.7

申请日：2002-11-29

申请人： LG Life Sciences Ltd.

发明人： NICONOVICH, Nancy ,  RITTENHOUSE, Stephen ,  McCLOSKEY, Lynn ,  PAEK, Kyong-Sook R & D Park, LG Life Sciences Ltd. ,  KIM, Mu-Yong R & D Park, LG Life Sciences, Ltd.

IPC分类号： A61K31/47

CPC分类号： A61K31/4375 ,  A61K31/407 ,  A61K2300/00

摘要： The present invention relates to a method of treating anti-bacterial infections which method comprises the separate, simultaneous or sequential administration to a patient in need thereof, of an effective amount of gemifloxacin or a salt thereof and a carbapenem antibacterial.