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公开(公告)号：EP2178870A1
公开(公告)日：2010-04-28
申请号：EP08793298.4
申请日：2008-08-18
发明人： KIM, Soon Ha , KIM, Hyoung Jin , KOO, Sun Young , CHUNG, Chul Woong , LEE, Sung Bae , PARK, Heui Sul , YOON, Seung Hyun , KWAK, Hyo Shin , SEO, Dong Ook , PARK, Eok
IPC分类号： C07D417/04 , C07D231/56 , C07D401/02 , A61P1/16 , A61P25/16 , A61P25/28 , A61P31/00 , A61P35/00 , A61P9/00 , A61P3/10
CPC分类号： C07D417/06 , A61K31/404 , A61K31/416 , A61K31/427 , A61K31/4439 , A61K31/445 , A61K31/454 , A61K31/4545 , A61K31/496 , A61K31/497 , A61K31/5377 , A61K31/541 , A61K31/675 , A61K45/06 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14 , C07D487/04 , C07F9/65583 , C07F9/65586
摘要： The present invention relates to indole or indazole compounds, pharmaceutically acceptable salts or isomers thereof which are useful for the prevention or treatment of cellular necrosis and necrosis-associated diseases. The present invention also relates to a method and a composition for the prevention or treatment of cellular necrosis and necrosis-associated diseases, comprising said indole or indazole compounds as an active ingredient.
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公开(公告)号：EP2178869A1
公开(公告)日：2010-04-28
申请号：EP08793297.6
申请日：2008-08-18
发明人： KIM, Soon Ha , KIM, Hyoung Jin , KOO, Sun Young , LEE, Sung Bae , PARK, Heui Sul , YOON, Seung Hyun , PAEK, Seung Yup , KWAK, Hyo Shin , SEO, Dong Ook , PARK, Eok
IPC分类号： C07D417/04 , C07D209/10 , A61K31/404 , A61P1/16 , A61P25/16 , A61P25/28 , A61P3/10 , A61P31/00 , A61P35/00 , A61P9/00
CPC分类号： C07D417/06 , A61K31/404 , A61K31/416 , A61K31/427 , A61K31/4439 , A61K31/445 , A61K31/454 , A61K31/4545 , A61K31/496 , A61K31/497 , A61K31/5377 , A61K31/541 , A61K31/675 , A61K45/06 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14 , C07D487/04 , C07F9/65583 , C07F9/65586
摘要： The present invention relates to indole or indazole compounds, pharmaceutically acceptable salts or isomers thereof which are useful for the prevention or treatment of cellular necrosis and necrosis-associated diseases. The present invention also relates to a method and a composition for the prevention or treatment of cellular necrosis and necrosis-associated diseases, comprising said indole or indazole compounds as an active ingredient.
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3.发明公开PHARMACEUTICAL COMPOSITION COMPRISING INDOLE COMPOUND 审中-公开药剂ZUSAMMENSETZUNG MIT EINER INDOLVERBINDUNG
公开(公告)号：EP2493469A2
公开(公告)日：2012-09-05
申请号：EP10827034.9
申请日：2010-10-25
申请人： LG Life Sciences Ltd
发明人： KIM, Soon Ha , KIM, Hyoung Jin , PARK, Heui Sul , GU, Seon Yeong , KWAK, Hyo Shin , PARK, Du Hee , KIM, Hyo Soo , CHO, Hyun Jai , KIM, Ji Hyun , KIM, Ju Young , PARK, Kwang Min
IPC分类号： A61K31/404 , A61P29/00 , A61P19/02 , A61P7/08 , A61P19/10
CPC分类号： A61K31/541 , A61K8/492 , A61K31/404 , A61K31/4184 , A61K31/427 , A61K31/496 , A61K31/497 , A61K2800/522 , A61Q19/00 , C07D413/04 , C07D417/04 , C07D417/14 , C07D471/04 , C07D487/04
摘要： The present invention relates to a pharmaceutical composition comprising a compound of formula (1), (2) or (3) as defined in the specification for the prevention or treatment of diseases associated with oxidative stress, mitochondria dysfunction, hypoxic injury, necrosis and/or ischemic reperfusion injury, and a cosmetic composition comprising an indole compound having an antioxidant effect.
摘要翻译： 本发明涉及药物组合物，其包含如说明书中定义的式（1），（2）或（3）化合物，其用于预防或治疗与氧化应激，线粒体功能障碍，缺氧损伤，坏死和/ 或缺血再灌注损伤，以及包含具有抗氧化作用的吲哚化合物的化妆品组合物
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4.发明公开
公开(公告)号：EP2220081A2
公开(公告)日：2010-08-25
申请号：EP08864050.3
申请日：2008-12-22
发明人： KIM, Soon Ha , LEE, Sung Bae , YOON, Seung Hyun , CHO, Mi Kyoung , KIM, Kyoung Hee , PARK, Heui Sul , KIM, Hyoung Jin
IPC分类号： C07D417/14 , A61P3/10
CPC分类号： C07D417/14 , C07D417/04 , C07D487/04
摘要： The present invention relates to new compounds of formula (1) exhibiting excellent activity for glucokinase, and pharmaceutical compositions comprising the same as an active ingredient.
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5.发明公开COMPOSITION FOR PREVENTING OR TREATING FATTY LIVER DISEASES 审中-公开ZUSAMMENSETZUNG ZUR PREVENTION ODER BEHANDLUNG VON FETTLEBERERKRANKUNGEN
公开(公告)号：EP3132795A1
公开(公告)日：2017-02-22
申请号：EP15779540.2
申请日：2015-04-17
发明人： KIM, Soon Ha , KIM, Hyoung Jin , PARK, Heui Sul , AHN, Seo Hyun , SHONG, Min Ho , CHUNG, Hyo Kyun
IPC分类号： A61K31/517 , A61K31/5377 , A61P1/16
摘要： The present invention relates to a pharmaceutical composition for preventing or treating fatty liver diseases, containing (tetrahydropyran-4-yl)-[2-phenyl-5-(1,1-dioxo-thiomorpholin-4-yl)methyl-1H-indol-7-yl]amine or a pharmaceutically acceptable salt thereof as active ingredients. (Tetrahydropyran-4-yl)-[2-phenyl-5-(1,1-dioxo-thiomorpholin-4-yl)methyl-1H-indol-7-yl]amine or a pharmaceutically acceptable salt thereof, according to the present invention, can effectively inhibit fatty liver, hepatitis and hepatic fibrosis and can be useful for preventing or treating NAFLD, and in particular, NASH.
摘要翻译： 本发明涉及含有（四氢吡喃-4-基） - [2-苯基-5-（1,1-二氧代硫代吗啉-4-基）甲基-1H-吲哚的脂肪肝疾病的预防或治疗药物组合物 -7-基]胺或其药学上可接受的盐作为活性成分。 （四氢吡喃-4-基） - [2-苯基-5-（1,1-二氧代 - 硫代吗啉-4-基）甲基-1H-吲哚-7-基]胺或其药学上可接受的盐，根据本发明 本发明能有效抑制脂肪肝，肝炎，肝纤维化，可用于预防或治疗NAFLD，特别是NASH。
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公开(公告)号：EP3037418A1
公开(公告)日：2016-06-29
申请号：EP14837897.9
申请日：2014-08-21
发明人： PARK, Heui Sul , KOO, Sun Young , KIM, Hyoung Jin , LEE, Sung Bae , KWAK, Hyo Shin , ARTEMOV, Vasily , KIM, Soon Ha
IPC分类号： C07D403/06 , A61K31/497 , A61P1/16 , A61P25/00
CPC分类号： C07D403/06 , C07D209/08 , C07D209/12 , C07D209/14 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D417/06 , C07D417/14 , C07D487/04
摘要： The present invention relates to an indole compound represented by formula (1), a pharmaceutically acceptable salt or isomer thereof, a composition for prevention or treatment of necrosis and necrosis-associated diseases, and a method for preparing the composition, the composition comprising the indole compound or the pharmaceutically acceptable salt or isomer thereof as an active ingredient.
摘要翻译： 本发明涉及由式（1）表示的吲哚化合物，其药学上可接受的盐或异构体，用于预防或治疗坏死和坏死相关疾病的组合物及其制备方法，该组合物包含吲哚 化合物或其药学上可接受的盐或异构体作为活性成分。
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7.发明授权INDOLE AND INDAZOLE DERIVATIVES HAVING A CELL-, TISSUE- AND ORGAN-PRESERVING EFFECT 有权与细胞，组织和器官的保护作用吲哚和吲唑衍生物
公开(公告)号：EP2230238B1
公开(公告)日：2013-12-11
申请号：EP09700417.0
申请日：2009-01-05
发明人： KIM, Soon Ha , KIM, Hyoung Jin , CHUNG, Chul Woong , PARK, Heui Sul , KWAK, Hyo Shin , KIM, Sung Ho , PARK, Jin Gu
IPC分类号： C07D417/04 , A61K31/404 , A61K31/416 , A61P43/00
CPC分类号： C07D417/04 , C07D209/08 , C07D231/54 , C07D401/04 , C07D401/14 , C07D403/04 , C07D405/12 , C07D405/14 , C07D413/14 , C07D417/14
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公开(公告)号：EP2178869B1
公开(公告)日：2013-06-12
申请号：EP08793297.6
申请日：2008-08-18
发明人： KIM, Soon Ha , KIM, Hyoung Jin , KOO, Sun Young , LEE, Sung Bae , PARK, Heui Sul , YOON, Seung Hyun , PAEK, Seung Yup , KWAK, Hyo Shin , SEO, Dong Ook , PARK, Eok
IPC分类号： C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14 , C07D487/04 , C07F9/6558 , A61K31/404 , A61P1/16 , A61P25/16 , A61P25/28 , A61P3/10 , A61P31/00 , A61P35/00 , A61P9/00
CPC分类号： C07D417/06 , A61K31/404 , A61K31/416 , A61K31/427 , A61K31/4439 , A61K31/445 , A61K31/454 , A61K31/4545 , A61K31/496 , A61K31/497 , A61K31/5377 , A61K31/541 , A61K31/675 , A61K45/06 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14 , C07D487/04 , C07F9/65583 , C07F9/65586
摘要： The present invention relates to indole or indazole compounds, pharmaceutically acceptable salts or isomers thereof which are useful for the prevention or treatment of cellular necrosis and necrosis-associated diseases. The present invention also relates to a method and a composition for the prevention or treatment of cellular necrosis and necrosis-associated diseases, comprising said indole or indazole compounds as an active ingredient.
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9.发明公开INDOLE AND INDAZOLE DERIVATIVES HAVING A CELL-, TISSUE- AND ORGAN-PRESERVING EFFECT 有权印度尼西亚麻省理工学院，GEWEBE- UND ORGANSCHUTZEFFEKT
公开(公告)号：EP2230238A2
公开(公告)日：2010-09-22
申请号：EP09700417.0
申请日：2009-01-05
发明人： KIM, Soon Ha , KIM, Hyoung Jin , CHUNG, Chul Woong , PARK, Heui Sul , KWAK, Hyo Shin , KIM, Sung Ho , PARK, Jin Gu
IPC分类号： C07D417/04 , A61K31/404 , A61K31/416 , A61P43/00
CPC分类号： C07D417/04 , C07D209/08 , C07D231/54 , C07D401/04 , C07D401/14 , C07D403/04 , C07D405/12 , C07D405/14 , C07D413/14 , C07D417/14
摘要： The present invention relates to a composition for preserving cells, tissues and organs, comprising as an active ingredient indole and indazole compounds of formula (1), or a pharmaceutically acceptable salt or isomer thereof, which are effective for preventing injury of organs, isolated cell systems or tissues caused by cold storage, transplant operation or post-transplantation reperfusion; a preservation method; and a preparation method of the composition.
摘要翻译： 本发明涉及一种用于保存细胞，组织和器官的组合物，其包含作为活性成分的式（1）的吲哚和吲唑化合物或其药学上可接受的盐或异构体，其有效预防器官损伤，分离的细胞 由冷藏，移植手术或移植后再灌注引起的系统或组织; 保存方法; 和组合物的制备方法。
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公开(公告)号：EP3037412A1
公开(公告)日：2016-06-29
申请号：EP14838146.0
申请日：2014-08-21
发明人： PARK, Heui Sul , KOO, Sun Young , KIM, Hyoung Jin , LEE, Sung Bae , KWAK, Hyo Shin , PAEK, Seung Yup , KIM, Soon Ha
IPC分类号： C07D209/30 , C07D403/12 , A61K31/404 , A61P1/16
摘要： The present invention relates to an indole amide compound represented by formula (1), a pharmaceutically acceptable salt or isomer thereof, a composition for prevention or treatment of necrosis and necrosis-associated diseases, and a method for preparing the composition, the composition comprising the indole compound or the pharmaceutically acceptable salt or isomer thereof as an active ingredient.
摘要翻译： 本发明涉及由式（1）表示的吲哚酰胺化合物，其药学上可接受的盐或异构体，用于预防或治疗坏死和坏死相关疾病的组合物，以及用于制备该组合物的方法，该组合物包含 吲哚化合物或其药学上可接受的盐或异构体作为活性成分。
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