SELECTIVE PHOTO ACTIVATION OF AMINO ACIDS FOR SINGLE STEP PEPTIDE COUPLING
    14.
    发明公开
    SELECTIVE PHOTO ACTIVATION OF AMINO ACIDS FOR SINGLE STEP PEPTIDE COUPLING 审中-公开
    SELEKTIVE PHOTOAKTIVIERUNG VONAMINOSÄURENZUR KOPPLUNG EINSTUFIGER PEPTIDE

    公开(公告)号:EP3107926A1

    公开(公告)日:2016-12-28

    申请号:EP15751793.9

    申请日:2015-02-23

    IPC分类号: C07K1/04 C07K1/10

    摘要: Disclosed herein are formulations, substrates, and arrays for amino acid and peptide synthesis on microarrays. In certain embodiments, methods for manufacturing and using the formulations, substrates, and arrays including one-step coupling, e.g., for synthesis of peptides in a C→N orientation are disclosed. In some embodiments, disclosed herein are formulations and methods for high efficiency coupling of biomolecules to a substrate.

    摘要翻译: 本文公开了用于微阵列上的氨基酸和肽合成的制剂,底物和阵列。 在某些实施方案中,公开了制备和使用包括一步偶联(例如用于合成C→N取向的肽)的制剂,底物和阵列的方法。 在一些实施方案中,本文公开了用于将生物分子高效耦合到底物的制剂和方法。

    METHODS AND COMPOSITIONS FOR AMPLIFIED ELECTROCHEMILUMINESCENCE DETECTION
    15.
    发明公开
    METHODS AND COMPOSITIONS FOR AMPLIFIED ELECTROCHEMILUMINESCENCE DETECTION 审中-公开
    放大电致化学发光检测的方法和组合物

    公开(公告)号:EP2956771A2

    公开(公告)日:2015-12-23

    申请号:EP14751871.6

    申请日:2014-02-17

    IPC分类号: G01N33/53 C12Q1/28

    摘要: Disclosed herein are formulations, substrates, and arrays. Also disclosed herein are methods for manufacturing and using the formulations, substrates, and arrays. Also disclosed are methods for identifying peptide sequences useful for diagnosis and treatment of disorders, and methods for using the peptide sequences for diagnosis and treatment of disorders, e.g., celiac disorder. In certain embodiments, substrates and arrays comprise a porous layer for synthesis and attachment of polymers or biomolecules.

    摘要翻译: 本文公开了配制剂,基质和阵列。 本文还公开了用于制造和使用制剂,基底和阵列的方法。 还公开了鉴定可用于诊断和治疗病症的肽序列的方法,以及使用该肽序列诊断和治疗病症例如乳糜泻的方法。 在某些实施方案中,基底和阵列包含用于聚合物或生物分子的合成和附着的多孔层。

    METHODS FOR ARRAY SYNTHESIS
    20.
    发明公开

    公开(公告)号:EP3617219A1

    公开(公告)日:2020-03-04

    申请号:EP19185540.2

    申请日:2013-11-14

    IPC分类号: C07K1/04 C07D257/06

    摘要: The present invention relates to methods of attaching a coupling molecule (e.g. a peptide, an amino acid, ...) to a substrate comprising a plurality of carboxylic acid groups for linking to a coupling molecule; contacting said substrate with a carboxylic acid activating compound formulation comprising a carbodiimide precursor (i.e. a tetrazole thione), wherein said carbodiimide precursor converts to a carbodiimide upon exposure to electromagnetic radiation at a defined wavelength; selectively exposing said carboxylic acid activating compound formulation to the electromagnetic radiation, thereby generating said carbodiimide and activating the carboxylic acid groups to form carbonyl groups on said substrate at a selectively exposed area; contacting the substrate with a coupling formulation comprising a coupling molecule and a solvent; coupling the coupling molecule to at least one of said plurality of carbonyl groups at said selectively exposed area. The invention also relates to corresponding carboxylic acid activating formulations.