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11.发明授权ANTIBODIES THAT BIND BOTH IL-17A AND IL-17F AND METHODS OF USING THE SAME 有权抗体既有IL-17A以及一个IL-17F结合和申请流程。
公开(公告)号：EP2142568B1
公开(公告)日：2014-03-19
申请号：EP07761460.0
申请日：2007-04-27
申请人： ZymoGenetics, Inc.
CPC分类号： C07K16/244 , A61K2039/505 , C07K2317/31 , C07K2317/76
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公开(公告)号：EP2313105B1
公开(公告)日：2013-07-24
申请号：EP09771227.7
申请日：2009-06-29
申请人： ZymoGenetics, Inc.
IPC分类号： A61K38/17 , C07K14/705
CPC分类号： C07K14/70503 , A61K38/00 , C07K14/70535
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13.发明公开Compositions and methods for inhibiting PDGFRBETA and VEGF-A 审中-公开Zusammensetzungen und Verfahren zur Hemmung von PDGFR-β和VEGF-A
公开(公告)号：EP2604279A1
公开(公告)日：2013-06-19
申请号：EP13159549.8
申请日：2009-03-27
申请人： ZymoGenetics, Inc.
发明人： Sivakumar, Pallavur V. , Gilbertson, Debra G. , Snavely, Marshall D. , Mabry, George R. , Yi, Eugene C. , Yao, Yue , Presnell, Scott R.
IPC分类号： A61K39/395 , A61P35/00 , C07K16/22 , C07K16/28
CPC分类号： C07K16/00 , A61K2039/505 , C07K16/22 , C07K16/2863 , C07K2317/21 , C07K2317/31 , C07K2317/33 , C07K2317/34 , C07K2317/55 , C07K2317/565 , C07K2317/622 , C07K2317/73 , C07K2317/76 , C07K2317/77 , C07K2317/90 , C07K2317/92
摘要： There is provided an isolated antibody that binds to VEGF-A and neutralizes VEGF-A activity, said antibody comprising a V L domain comprising CDRs LCDR1, LCDR2 and LCDR3, and a V H domain comprising CDRs HCDR1, HCDR2 and HCDR3, wherein:
LCDR1 has the amino acid sequence shown in SEQ ID NO: 448;
LCDR2 has the amino acid sequence shown in SEQ ID NO: 449;
LCDR3 has the amino acid sequence shown in SEQ ID NO: 450;
HCDR1 has the amino acid sequence shown in SEQ ID NO: 451;
HCDR2 has the amino acid sequence shown in SEQ ID NO: 452;
HCDR3 has an amino acid sequence selected from the group consisting of SEQ ID NOs: 453-461.摘要翻译： 提供了结合VEGF-A并中和VEGF-A活性的分离的抗体，所述抗体包含包含CDR1 LCDR1，LCDR2和LCDR3的VL结构域，以及包含CDR HCDR1，HCDR2和HCDR3的VH结构域，其中：LCDR1具有 SEQ ID NO：448所示的氨基酸序列; LCDR2具有SEQ ID NO：449所示的氨基酸序列; LCDR3具有SEQ ID NO：450所示的氨基酸序列; HCDR1具有SEQ ID NO：451所示的氨基酸序列; HCDR2具有SEQ ID NO：452所示的氨基酸序列; HCDR3具有选自SEQ ID NO：453-461的氨基酸序列。
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14.发明授权COMBINATION OF BLYS INHIBITION AND MYCOPHENOLATE MOFETIL FOR TREATMENT OF AUTOIMMUNE DISEASE 有权作者BLYS抑制和霉酚酸酯用于自身免疫性疾病疗法相结合
公开(公告)号：EP2139517B1
公开(公告)日：2013-05-29
申请号：EP08744487.3
申请日：2008-03-27
发明人： PONCE, JR., Rafael, A. , WALLIS, Wayne, J. , HOLDREN, Matthew, S. , ZUCKERMAN, Linda , LITTAU, Alisa, M. , VAN NESS, Kirk, P. , PENA ROSSI, Claudia , GRAFFNER, Hans, Otto, Lennart
IPC分类号： A61K45/06 , A61K38/19 , A61K31/365 , A61P37/06
CPC分类号： A61K39/3955 , A61K31/5377 , A61K38/1793 , A61K45/06 , A61K2300/00
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15.发明公开Methods of treating pain and inflammation in neuronal tissue using IL-31 antagonists 审中-公开一种用于使用IL-31拮抗剂在神经组织治疗疼痛和炎症的方法
公开(公告)号：EP2594585A1
公开(公告)日：2013-05-22
申请号：EP13154292.0
申请日：2007-01-10
申请人： Zymogenetics, Inc.
发明人： Yao, Yue , Bilsborough, Janine , Krejsa, Cecile , Zuckerman, Linda , Rogge, Mark
CPC分类号： C07K16/244 , A61K38/1793 , A61K39/3955 , A61K2039/505 , C07K16/2866 , C07K2317/14 , C07K2317/24 , C07K2317/34 , C07K2317/52 , C07K2317/76
摘要： There is provided an isolated monoclonal antibody or binding fragment thereof that specifically binds to a polypeptide consisting of amino acid residues 27-164 of SEQ ID NO:2, for use in the treatment of inflammation in neuronal tissue in a mammal.
摘要翻译： 本发明提供分离的单克隆抗体或其结合片段特异性结合的多肽也由氨基酸残基的SEQ ID NO 27-164：2，用于在哺乳动物中神经元组织的治疗炎症的用途。
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公开(公告)号：EP1373508B1
公开(公告)日：2013-04-24
申请号：EP02721533.4
申请日：2002-03-22
申请人： ZymoGenetics, Inc.
IPC分类号： C12N9/12
CPC分类号： C07K14/715 , A61K38/00
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公开(公告)号：EP2264175B1
公开(公告)日：2012-11-21
申请号：EP10176653.3
申请日：1997-10-16
申请人： ZymoGenetics, Inc.
发明人： Deisher, Theresa A. , Conklin, Darrell C. , Raymond, Fenella C. , Bukowski, Thomas R. , Julien, Susan D. , Hansen, Brigit , Sheppard, Paul O.
CPC分类号： C12N5/0657 , A61K38/00 , A61K47/62 , A61K47/6835 , C07K14/50 , C07K16/22 , C07K2319/00 , C12N2501/119
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18.发明公开
公开(公告)号：EP2295577A3
公开(公告)日：2012-08-08
申请号：EP10185147.5
申请日：2000-03-09
申请人： ZymoGenetics, Inc.
发明人： Novak, Julia E , Sprecher, Cindy, A , Gross, Jane A , Nelson, Andrew J. , Dillon, Stacey, R , Hammond, Angela K.
IPC分类号： C12N15/19 , C07K14/52 , C12N15/62 , C12N15/85 , C07K16/24 , C12Q1/68 , G01N33/68 , A61K38/19
CPC分类号： C07K14/52 , A61K38/00 , C07K2319/00 , C07K2319/55
摘要： There is provided a method of producing an antibody to an inoculated zalpha11 polypeptide comprising isolating an antibody elicited by the inoculated polypeptide, wherein the polypeptide is selected from the group consisting of: a) a polypeptide consisting of the amino acid sequence of SEQ ID NO: 72; b) a polypeptide consisting of the amino acid sequence of SEQ ID NO: 73.
摘要翻译： 提供了一种产生针对接种的zalpha11多肽的抗体的方法，包括分离由接种的多肽引发的抗体，其中所述多肽选自：a）由SEQ ID NO：2的氨基酸序列组成的多肽， 72; b）由SEQ ID NO：73的氨基酸序列组成的多肽。
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19.发明公开Humanized antibody molecules specific for IL-31 有权F-Il-31 spezifische humanisierteAntikörpermoleküle
公开(公告)号：EP2471817A2
公开(公告)日：2012-07-04
申请号：EP12161272.5
申请日：2008-12-08
IPC分类号： C07K16/24 , A61K39/395
CPC分类号： C07K16/244 , A61K2039/505 , C07K2317/24 , C07K2317/51 , C07K2317/515 , C07K2317/52 , C07K2317/56 , C07K2317/76 , C07K2317/92
摘要： There is provided an isolated antibody or antibody fragment that binds to human IL-31, comprising: a) a humanized heavy chain variable domain comprising CDR1, CDR2, and CDR3 consisting of amino acid sequences SEQ ID NO: 1, 2 and 3, respectively; and b) a humanized light chain variable domain comprising CDR1, CDR2, and CDR3 consisting of amino acid sequences of SEQ ID NO: 5, 6 and 7, respectively.
摘要翻译： 提供了结合人IL-31的分离的抗体或抗体片段，其包含：a）包含分别由氨基酸序列SEQ ID NO：1,2和3组成的CDR1，CDR2和CDR3的人源化重链可变结构域 ; 和b）包含分别由SEQ ID NO：5,6和7的氨基酸序列组成的CDR1，CDR2和CDR3的人源化轻链可变结构域。
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公开(公告)号：EP2426146A3
公开(公告)日：2012-05-30
申请号：EP11185989.8
申请日：2008-12-08
申请人： ZymoGenetics, Inc.
发明人： Jaspers, Stephen R. , Rixon, Mark W. , Dillon, Stacey R. , Ramsdell, Frederick J. , Krejsa, Cecile M. , Yi, Eugene C.
IPC分类号： C07K16/24 , A61K39/395
CPC分类号： C07K16/244 , A61K2039/505 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , Y10S530/809
摘要： There is provided an anti-human IL-21 monoclonal antibody comprising: (a) a heavy chain region comprising: (i) a heavy chain variable region CDR1 comprising SEQ ID NO: 63; (ii) a heavy chain variable region CDR2 comprising SEQ ID NO: 65; and (iii) a heavy chain variable region CDR3 comprising SEQ ID NO: 67; and (b) a light chain region comprising: (i) a light chain variable region CDR1 comprising SEQ ID NO: 71; (ii) a light chain variable region CDR2 comprising SEQ ID NO: 73; and (iii) a light chain variable region CDR3 comprising SEQ ID NO: 75. There is also provided a hybridoma designated 366.328.10, wherein the hybridoma is deposited with the American Type Culture Collection having the ATCC Patent Deposit Designation PTA-8789.
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