公开(公告)号：EP2313105B1

公开(公告)日：2013-07-24

申请号：EP09771227.7

申请日：2009-06-29

申请人： ZymoGenetics, Inc.

发明人： BIRKS, Carl, W. ,  FOX, Brian, A. ,  RIXON, Mark, W. ,  ELLSWORTH, Jeff, L.

IPC分类号： A61K38/17 ,  C07K14/705

CPC分类号： C07K14/70503 ,  A61K38/00 ,  C07K14/70535

公开(公告)号：EP2411407A1

公开(公告)日：2012-02-01

申请号：EP10722828.0

申请日：2010-03-26

申请人： Zymogenetics, Inc.

发明人： PAN, Qi ,  BIRKS, Carl, W. ,  SIVAKUMAR, Pallavur, V.

IPC分类号： C07K14/71 ,  C12N15/62 ,  C07K16/22 ,  A61K39/395

CPC分类号： C07K14/71 ,  A61K38/00 ,  C07K16/22 ,  C07K2317/73 ,  C07K2319/00 ,  C12N15/62

摘要： Disclosed are bispecific binding proteins comprising a antibody/soluble receptor bispecific binding protein that reduces the biological activity of both VEGF-A and FGF. The FGF binding moieties are generally soluble FGFR3 or FGFR2. An Fc polypeptide is fused to the C-terminus of the FGF binding moiety and VEGF-A binding moiety are polypeptides fused using peptide or polypeptide linker sequences, and can be expressed as single bispecific binding protein. The bispecific antibody/soluble receptor binding proteins can be used to treat cancers characterized by solid tumor growth as well as other diseases.

公开(公告)号：EP2313105A1

公开(公告)日：2011-04-27

申请号：EP09771227.7

申请日：2009-06-29

申请人： ZymoGenetics, Inc.

发明人： BIRKS, Carl, W. ,  FOX, Brian, A. ,  RIXON, Mark, W. ,  ELLSWORTH, Jeff, L.

IPC分类号： A61K38/17 ,  C07K14/705

CPC分类号： C07K14/70503 ,  A61K38/00 ,  C07K14/70535

摘要： Disclosed are soluble hybrid Fcγ receptor (FcγR) polypeptide compositions and related methods of using such polypeptides to treat IgG-mediated and immune complex-mediated inflammation. Also disclosed are related compositions and methods for producing the soluble hybrid FcγR polypeptides.

摘要翻译： 提供了分离的可溶性多肽，其包含与选自SEQ ID NO：40的氨基酸残基36-301的多肽区域具有至少90％序列同一性的氨基酸序列; SEQ ID NO：42的氨基酸残基43-310; SEQ ID NO：44的氨基酸残基21-286; 或SEQ ID NO：46的氨基酸残基21-286; 其中所述多肽能够特异性结合IgG的Fc区。

公开(公告)号：EP1483298A2

公开(公告)日：2004-12-08

申请号：EP03739766.8

申请日：2003-02-11

申请人： ZymoGenetics, Inc.

发明人： FOX, Brian, A. ,  MOORE, Margaret, D. ,  SWIDEREK, Kristine, M. ,  BIRKS, Carl, W.

IPC分类号： C07K19/00 ,  C07K14/71 ,  C07K16/46 ,  C12N15/00 ,  C12N5/06 ,  C12P21/06

CPC分类号： C07K14/49 ,  A61K38/00 ,  C07K2319/00 ,  C07K2319/50 ,  C07K2319/735 ,  C12N2710/14043

摘要： Proteins consisting of, from amino to carboxyl terminus, a first PDGF-D growth factor domain polypeptide, a linker polypeptide, and a second PDGF-D growth factor domain polypeptide, and materials and methods for making the proteins are disclosed. Each of the first and second PDGF-D growth factor domain polypeptides consists of a sequence of amino acid residues as shown in SEQ ID NO:2 or SEQ ID NO:4 from amino acid x to amino acid y, wherein x is an integer from 246 to 258, inclusive, and y is an integer from 365-370, inclusive. The linker polypeptide consists of from 11-40 amino acid residues. The proteins can be used to stimulate the production of bone and/or connective tissue in both humans and non-human animals.