公开(公告)号：EP1896053A1

公开(公告)日：2008-03-12

申请号：EP05764281.1

申请日：2005-07-06

申请人： ZymoGenetics, Inc.

发明人： MOORE, Emma, E. ,  ELLSWORTH, Jeff, L.

IPC分类号： A61K38/18 ,  A61K38/17 ,  A61K39/395 ,  A61P19/00 ,  A61P11/00 ,  A61P25/00 ,  A61P29/00 ,  A61P35/00 ,  A61P9/00

CPC分类号： A61K38/1825 ,  A61K31/722 ,  A61K31/724 ,  A61K31/728 ,  A61K39/39541 ,  A61K39/3955 ,  A61K45/06 ,  A61K2300/00

摘要： FGF18 is known to stimulate the proliferation of chondrocytes, bone, and nervous tissue, resulting in repair of diseased tissue. When an IL-1 antagonist is administered in addition to FGF18, the effects on the IL-1 mediated disease and also, the effect on cartilage, bone, and nervous cell proliferation, are found to be greater than administration of FGF18 or the IL-1 antagonist alone. The present invention encompasses a pharmaceutical composition that combines FGF18 with IL-1 antagonist and uses thereof in the treatment of IL-1 mediated disease, wherein the IL-1-mediated disease is rheumatoid arthritis.

公开(公告)号：EP1123393A1

公开(公告)日：2001-08-16

申请号：EP99950190.1

申请日：1999-10-05

申请人： ZymoGenetics, Inc.

发明人： CONKLIN, Darrell, C. ,  ELLSWORTH, Jeff, L.

IPC分类号： C12N15/12 ,  C07K14/47 ,  C12Q1/68 ,  C07K16/18 ,  A61K38/17 ,  C12N15/62

CPC分类号： C07K14/4702 ,  A61K38/00 ,  C07K2319/00

摘要： The present invention relates to polynucleotide and polypeptide molecules for zfsta2, a novel member of the follistatin family. The polypeptides, and polynucleotides encoding them are useful for binding to members of the TGF-β family and mediating central nervous system, reproductive, hematopoietic and bone-related activities. The present invention also includes antibodies to the zfsta2 polypeptides.

公开(公告)号：EP1551426B1

公开(公告)日：2014-06-25

申请号：EP03773163.5

申请日：2003-10-07

申请人： ZymoGenetics, Inc.

发明人： ELLSWORTH, Jeff, L.

IPC分类号： A61K31/728 ,  A61K31/717 ,  A61K38/18 ,  C07K14/50

CPC分类号： A61K9/0019 ,  A61K31/728 ,  A61K38/1825 ,  A61K45/06 ,  A61K47/36 ,  C07C51/38 ,  C07C67/343 ,  C07C57/58 ,  C07C69/65 ,  A61K2300/00

公开(公告)号：EP2313105B1

公开(公告)日：2013-07-24

申请号：EP09771227.7

申请日：2009-06-29

申请人： ZymoGenetics, Inc.

发明人： BIRKS, Carl, W. ,  FOX, Brian, A. ,  RIXON, Mark, W. ,  ELLSWORTH, Jeff, L.

IPC分类号： A61K38/17 ,  C07K14/705

CPC分类号： C07K14/70503 ,  A61K38/00 ,  C07K14/70535

公开(公告)号：EP1896053B1

公开(公告)日：2018-10-31

申请号：EP05764281.1

申请日：2005-07-06

申请人： ZymoGenetics, Inc.

发明人： MOORE, Emma, E. ,  ELLSWORTH, Jeff, L.

IPC分类号： A61K38/18 ,  A61K38/17 ,  A61K39/395 ,  A61P19/00 ,  A61P11/00 ,  A61P25/00 ,  A61P29/00 ,  A61P35/00 ,  A61P9/00

CPC分类号： A61K38/1825 ,  A61K31/722 ,  A61K31/724 ,  A61K31/728 ,  A61K39/39541 ,  A61K39/3955 ,  A61K45/06 ,  A61K2300/00

摘要： FGF18 is known to stimulate the proliferation of chondrocytes, bone, and nervous tissue, resulting in repair of diseased tissue. When an IL-1 antagonist is administered in addition to FGF18, the effects on the IL-1 mediated disease and also, the effect on cartilage, bone, and nervous cell proliferation, are found to be greater than administration of FGF18 or the IL-1 antagonist alone. The present invention encompasses a pharmaceutical composition that combines FGF18 with IL-1 antagonist and uses thereof in the treatment of IL-1 mediated disease, wherein the IL-1-mediated disease is rheumatoid arthritis.

公开(公告)号：EP2313105A1

公开(公告)日：2011-04-27

申请号：EP09771227.7

申请日：2009-06-29

申请人： ZymoGenetics, Inc.

发明人： BIRKS, Carl, W. ,  FOX, Brian, A. ,  RIXON, Mark, W. ,  ELLSWORTH, Jeff, L.

IPC分类号： A61K38/17 ,  C07K14/705

CPC分类号： C07K14/70503 ,  A61K38/00 ,  C07K14/70535

摘要： Disclosed are soluble hybrid Fcγ receptor (FcγR) polypeptide compositions and related methods of using such polypeptides to treat IgG-mediated and immune complex-mediated inflammation. Also disclosed are related compositions and methods for producing the soluble hybrid FcγR polypeptides.

摘要翻译： 提供了分离的可溶性多肽，其包含与选自SEQ ID NO：40的氨基酸残基36-301的多肽区域具有至少90％序列同一性的氨基酸序列; SEQ ID NO：42的氨基酸残基43-310; SEQ ID NO：44的氨基酸残基21-286; 或SEQ ID NO：46的氨基酸残基21-286; 其中所述多肽能够特异性结合IgG的Fc区。

公开(公告)号：EP1551426A2

公开(公告)日：2005-07-13

申请号：EP03773163.5

申请日：2003-10-07

申请人： ZymoGenetics, Inc.

发明人： ELLSWORTH, Jeff, L.

IPC分类号： A61K31/728 ,  A61K31/717 ,  A61K38/18 ,  C07K14/50

CPC分类号： A61K9/0019 ,  A61K31/728 ,  A61K38/1825 ,  A61K45/06 ,  A61K47/36 ,  C07C51/38 ,  C07C67/343 ,  C07C57/58 ,  C07C69/65 ,  A61K2300/00

摘要： FGF18 is known to stimulate the proliferation of chondrocytes, resulting in increased cartilage formation. When hyaluronic acid is administered in addition to FGF18, the effects on chondrocyte proliferation and production of matrix were found to be greater than administration of FGF18 or hyaluronic acid alone.